PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

“…Background Various cancer immunotherapies rely on the T cell-mediated recognition of peptide antigens presented on human leukocyte antigens (HLA). …”
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Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial by Xinxing Li, Dae Young Kim, Yunho Sung, Donghyun Kim, Seohyun Ahn, Hyejung Shin, Nur Afiqah Binti Zulkifli, Ji-won Seo, Shu Jiang, Parivash Jamrasi, SoYoung Ahn, Jun Hyun Bae, HeeKyung Yeo, Hayoung Park, Wook Song

“…Background: Given the antioxidant properties of curcumin, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults. …”
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Legume-based green concentrate alleviates negative energy balance and enhances performance, metabolic health, and profitability in postpartum Holstein Friesian cows by Renny Fatmyah Utamy, Ambo Ako, Zyahrul Ramadan, Yasuyuki Ishii, Mohammad Mijanur Rahman, Kannika Umpuch, Azisah Nurfadilah, Gemal Umar Akmal Alkatiry, Muhammad Akram, Jiant Muthahra Maharani

“…Background and Aim: Negative energy balance (NEB) is a common metabolic disorder in postpartum dairy cows that compromises milk yield, metabolic health, and reproductive function. …”
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Enhancing the nutritional profile of purple sweet potato flour through fermentation with Lactiplantibacillus plantarum InaCC B157: A functional food perspective by Tiurma Pasaribu, Yati Sudaryati Soeka, Novik Nurhidayat, Suciatmih Suciatmih, Titin Yulinery, Evi Triana, Tri Ratna Sulistiyani, Ninik Setyowati, Desty Dwi Sulistyowati, Dwi Ningsih Susilowati

“…This study aimed to evaluate the ability of Lactiplantibacillus plantarum InaCC B157 to enhance the biochemical and functional composition of purple sweet potato flour. Materials and Methods: Six L. plantarum strains were screened for enzymatic activities. …”
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Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression by Ludivine Obry, Raissa Medina-Santos, Myriam Rahmouni, Josselin Noirel, Toufik Labib, Pilar Galan, Jean-Louis Spadoni, Gaëlle Gendronneau, Randa Jdid, Sandra Courrèges, Julie Latreille, Nada André, Jean-François Zagury, Sigrid Le Clerc

“…BackgroundSkin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders. …”
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Salivary mycobiome alterations in HIV-infected MSM: dominance of Pseudogymnoascus and functional shifts across disease stages by Ying Guo, Ying Guo, Lu Lin, Miao Zhang, Yixi Yu, Yan Wang, Jie Cao, Yuchen Li, Xintong Sun, Meilin Guan, Shuo Wen, Xin Wang, Zhen Fang, Wenshan Duan, Junyi Duan, Tao Huang, Wei Xia, Shan Guo, Feili Wei, Dongxiang Zheng, Xiaojie Huang

“…BackgroundOral health is increasingly recognized as a crucial determinant of overall health in people living with HIV/AIDS (PLWHA). …”
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Adipose tissue content of alpha-linolenic acid and the risk of ischemic stroke and ischemic stroke subtypes: A Danish case-cohort study. by Christian Sørensen Bork, Stine Krogh Venø, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Anne Tjønneland, Philip C Calder, Kim Overvad, Erik Berg Schmidt

“…<h4>Background</h4>The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease.…”
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Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study by Leah Trumet, Leah Trumet, Bettina Grötsch, Abbas Agaimy, Kerstin Galler, Carol Geppert, Linus Winter, Linus Winter, Jutta Ries, Jutta Ries, Marco Kesting, Marco Kesting, Manuel Weber, Manuel Weber

“…BackgroundImmune cells play a major role in the development and progression of inflammatory and malignant diseases of the oral mucosa. …”
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The Impact of Nanoparticle Coatings on the Color of Teeth Restored Using Dental Adhesives Augmented with Magnetic Nanoparticles by Carina Sonia Neagu, Andreea Codruta Novac, Cristian Zaharia, Meda-Lavinia Negrutiu, Izabell Craciunescu, Vlad Mircea Socoliuc, Catalin Nicolae Marin, Ionela-Amalia Bradu, Luminita Maria Nica, Marius Stef, Virgil-Florin Duma, Mihai Romînu, Cosmin Sinescu

“…<i>Background and Objectives</i>: Dental adhesives augmented with magnetic nanoparticles (MNPs) have been proposed to prevent microleakages. …”
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Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle by Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Rinat I. Sultanov, Andrey V. Zhelankin, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, Takashi Kudo, Satoru Takahashi, Ryo Fujita

“…Abstract Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. …”
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A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV. by Krisann K Oursler, John D Sorkin, Alice S Ryan, Leslie I Katzel

“…<h4>Background</h4>HIV-infected adults have increased risk for age-related diseases and low cardiorespiratory fitness that can be prevented and improved with exercise. …”
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Improving nutritional quality and aflatoxin detoxification of peanut meal by co-fermentation with Weizmannia coagulans, Bacillus subtilis, and supplemented enzymes by Youwei Chen, Hao Huang, Dan Li, Limei Zou, Wendi Yu, Weiwei Dong, Xiang Yu, Yanli Feng, Jun Liu, Shumiao Zhao, Yunxiang Liang, Yuanliang Hu, Nan Peng

“…Abstract Background Peanut meal, a high-protein agricultural by-product, faces challenges as animal feed due to anti-nutritional factors, poor protein digestibility, aflatoxin contamination, and imbalanced amino acids. …”
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Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3 by Yichi Wu, Sujuan Li, Jingyi Zhang, Anran Tian, Xiangyao Wang, Xi Yang, Fucheng Meng, Qing Li, Yuan Gao, Yingying Li, Furong Liang, Minglan Yao, Xiaoping Luo, Cai Zhang

“…Given that skeletal muscle plays a crucial role in systemic metabolism, we investigated how maternal prepregnancy high‐fat diet (HFD) influences muscle fibre composition and metabolic function in offspring. Methods We established mouse models with a prepregnancy chow diet (CD) and a prepregnancy high‐fat diet (HFD) for 8 weeks to compare metabolic phenotypes in offspring. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…<h4>Background</h4>Globally, over 16 million children were exposed to HIV during pregnancy but remain HIV-free at birth and throughout childhood by 2022. …”
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Combined microbiome and metabolomics analysis of yupingfeng san fermented by Bacillus coagulans: insights into probiotic and herbal interactions by Yu Kang, Yanting Sun, Jinzhong Cui, Yuzhen Song, Zilong Sun, Huan Li, Ruiyan Niu, Hongxing Qiao

“…Background Yupingfeng san is a traditional Chinese medicine formula composed of siler, atractylodes, and astragalus. …”
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Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome by Vatn SS, Hansen SH, Tannæs TM, Brackmann S, Olbjørn C, Bergemalm D, Keita ÅV, Gomollon F, Detlie TE, Kalla R, Satsangi J, Jahnsen J, Vatn MH, Halfvarson J, Hov JR, Ricanek P, Moen AEF

“…Simen Svendsen Vatn,1– 3,&amp;ast; Simen Hyll Hansen,1,4,&amp;ast; Tone Møller Tannæs,5 Stephan Brackmann,1,2 Christine Olbjørn,1,6 Daniel Bergemalm,7 Åsa V Keita,8 Fernando Gomollon,9 Trond Espen Detlie,1,2 Rahul Kalla,10 Jack Satsangi,10,11 Jørgen Jahnsen,1,2 Morten Harald Vatn,1 Jonas Halfvarson,7 Johannes Roksund Hov,1,4,12 Petr Ricanek,2,13 Aina EF Moen1,5,14 On behalf of the IBD-Character Consortium1Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; 3Innlandet Hospital Trust, Gjøvik, Norway; 4Norwegian PSC Research Center and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway; 5Section for Clinical Molecular Biology (Epigen), Akershus University Hospital, Lørenskog, Norway; 6Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway; 7Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 8Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 9Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain; 10Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; 11Translational Gastroenterology Unit, Medical Sciences/ Experimental Medicine Division, University of Oxford, Oxford, UK; 12Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; 13Department of Gastroenterology, lovisenberg Diaconal Hospital, Oslo, Norway; 14Department of Virology, Norwegian Institute of Public Health, Oslo, Norway&amp;ast;These authors contributed equally to this workCorrespondence: Simen Svendsen Vatn, Innlandet Hospital Trust, Gjøvik, Norway, Tel +47 94277594, Email bikkjas@hotmail.comBackground: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes.Methods: A cohort of 237 individuals were included from five countries: Crohn’s disease (CD, n = 72), ulcerative colitis (UC, n = 57), symptomatic non-IBD controls (SC, n = 78) and healthy controls (HC, n = 30). …”
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Impact of Long‐Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using 31P/1H MRS and MRI by Antoine Naëgel, Magalie Viallon, Hélène Ratiney, Thu Nguyen, Benjamin Leporq, Djahid Kennouche, Thomas Grenier, Franziska Grundler, Robin Mesnage, Jean‐Michel Guy, Robin Schultze, Françoise Wilhelmi de Toledo, Pierre Croisille

“…We explored the impact of long‐term fasting (12 days, 250 kcal/day) on muscle structure, metabolism and performance. Methods We prospectively assessed muscle volume, composition, relaxometry data and lipid metabolism in 32 subjects (16 men; 50% over 50 years old) before fasting, at the end of fasting and 1 month post‐fasting. …”
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Nutritional quality and on-package marketing of pre-packaged foods and non-alcoholic beverages for sale in Senegalese supermarkets by Yassarath Onifade, Adama Diouf, Mane Hélène Faye, Fatou Fall, Gary Sacks, Nicole Idohou-Dossou, Boyd Swinburn, Stefanie Vandevijvere

“…Abstract Background The high availability and marketing of unhealthy foods has contributed to unhealthy diets. …”
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Tailored Magnetic Fe₃O₄-Based Core–Shell Nanoparticles Coated with TiO₂ and SiO₂ via Co-Precipitation: Structure–Property Correlation fo... by Elena Emanuela Herbei, Daniela Laura Buruiana, Alina Crina Muresan, Viorica Ghisman, Nicoleta Lucica Bogatu, Vasile Basliu, Claudiu-Ionut Vasile, Lucian Barbu-Tudoran

“…<b>Methods:</b> Fe₃O₄, Fe₃O₄@TiO₂, and Fe₃O₄@SiO₂ nanoparticles were synthesized via co-precipitation at varying temperatures from iron salt precursors. …”
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Immunohistochemical analysis of PD-L1, CD4, CD8, CD20, and PU.1 expression in a dedifferentiated chondrosarcoma: the clinical and prognostic value by Olga V. Kovaleva, Irena V. Boulytcheva, Dmitrii V. Rogozhin, Alexei N. Gratchev, Polina L. Prishchep, Nikolay E. Kushlinskii

“…Background: Dedifferentiated chondrosarcoma (DDCS) is a rare and extremely aggressive variant of mesenchymal bone tumors, with a biphasic structure represented by the classical chondrosarcoma elements, usually of low or intermediate grade, combined with a sharp transition to a highly malignant (high grade) non-cartilaginous sarcoma. …”
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