Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics by Tao Jiang, Peipei Du, Dongxia Liu, Hetao Chen, Yujin Ma, Bin Hu, Jingna Li, Hongwei Jiang, Xuejiao Li

“…BackgroundDiabetes mellitus (DM) is a metabolic disease with high morbidity, which significantly affects human life and health expenditures. …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…Background: Buddleja polystachya, Trema orientalis, and Cissus rotundifolia were applied locally for various ocular purposes, while receiving few scientific evaluations. …”
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Effects of anthocyanin-rich Napier grass silage on feed intake, milk production, plasma profile, and nutritional digestibility in lactating crossbred Saanen goats by Anan Chaokaur, Janjira Sittiya, Pornpan Saenphoom, Pattaraporn Poommarin, Wilasinee Inyawilert, Jai-Wei Lee, Attapol Tiantong

“…Background and Aim: Anthocyanins are potent antioxidants and scavengers of free radicals found in fruits, purple corn, and other naturally occurring purple plants. …”
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Microbial and clinical disparities in pneumonia: insights from metagenomic next-generation sequencing in patients with community-acquired and severe pneumonia by Wang Luo, Shuhua Zhang, Jinhuan Sun, Jinhuan Sun, Jianhui Xu, Weihua Huang, Ruiqing Hao, Zhao Ou, Zhao Ou, Ziyang Wen, Ziyang Wen, Daiwei Wang, Daiwei Wang, Guanhua Xiao, Hangming Dong

“…BackgroundCommunity-acquired pneumonia (CAP) is a major global cause of death, with its varying symptoms and severity complicating diagnosis and treatment. …”
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Epigenome-wide analysis reveals potential biomarkers for radiation-induced toxicity risk in prostate cancer by Carlos Lopez-Pleguezuelos, Miguel E. Aguado-Barrera, Ana Carballo-Castro, Paula Peleteiro, Patricia Calvo-Crespo, Begoña Taboada-Valladares, Ramón Lobato-Busto, Olivia Fuentes-Ríos, Javier Galego-Carro, Carla Coedo-Costa, Antonio Gómez-Caamaño, Ana Vega

“…Abstract Background Prostate cancer is the second most common cancer globally, with radiation therapy (RT) being a key treatment for clinically localized and locally advanced cases. …”
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The state of the immunophenotype of blood lymphocytes in patients with newly diagnosed type 2 diabetes in the post-COVID period by V.V. Popova, N.V. Het’man, Ya.I. Labanets, H.V. Kulikovska, O.E. Lavrinenko, O.V. Furmanova, O.I. Kovzun, M.D. Tronko

“…Background. Today, the indicators of the subpopulation blood composition are one of the key characteristics of immune function. …”
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Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity by Valentina Salvi, Carolina Gaudenzi, Barbara Mariotti, Gaia Giongrandi, Silvia Alacqua, Veronica Gianello, Tiziana Schioppa, Laura Tiberio, Angela Ceribelli, Carlo Selmi, Paolo Bergese, Stefano Calza, Annalisa Del Prete, Silvano Sozzani, Flavia Bazzoni, Daniela Bosisio

“…Abstract Background The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracellular pool. …”
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A scRNA-seq reference contrasting living and early post-mortem human retina across diverse donor states by Luning Yang, Yiwen Tao, Qi Pan, Tengda Cai, Yunyan Ye, Jianhui Liu, Yang Zhou, Yongqing Shao, Quanyong Yi, Zen Huat Lu, Lie Chen, Gareth McKay, Richard Rankin, Weihua Meng

“…Abstract Background Current human retina studies predominantly utilize post-mortem tissue, and the sample accessibility constraints make the characterization of the living human retina at single-cell resolution a challenge. …”
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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration by Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson

“…Abstract Background Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. …”
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Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice by Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong

“…Abstract Background Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. …”
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Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population by Wenjian Lin, Zixin Liang, Junxuan Fang, Yu Liu, Lei Lei, Jiawen Lin, Bin Xia, Zhihua Zheng, Jingqiu Yuan, Chun Tang

“…<b>Background:</b> Population differences in gut microbiota composition and related metabolites may influence their potential causal relationship with chronic kidney disease (CKD); however, this relationship remains poorly understood in the Chinese population. …”
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Prevalence and influencing factors of micronutrient powder adoption among children aged 6–24 months by parental and grandparental caregivers: an analysis from rural China by Yiran Tian, Fangqun Leng, Xinru Zhou, Yadi He, Linhua Li, Ruixue Ye, Andrew Rule, Jieyuan Feng, Scott Rozelle, Yuju Wu, Huan Zhou

“…Abstract Background Micronutrient powder (MNP or Yingyangbao, a dietary supplement that contains multiple vitamins and minerals) programs can reduce the risk of anemia among children. …”
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Impact of dairy farming on gut microbiota structure and diversity of practitioners by Zhaojie WANG, Xixiao MA, Xianxia LIU, Yanggui CHEN, Xueying XIANG, Wanting XU, Jiguo JIN, Fan WU, Xiangnan WEI, Jianyong WU, Fuye LI

“…BackgroundAnimal farming may affect the structure and diversity of gut microbiota of farm workers, but it needs more studies to provide solid evidence. …”
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Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation by Yu Feng, Qian Zhao, Yifan Zhao, Chen Ma, Meiling Tian, Xiaosong Hu, Fang Chen, Daotong Li

“…Abstract Background Inflammatory bowel disease (IBD) is a gastrointestinal inflammatory disorder characterized by disturbed interactions between gut microbiota and host immune response. …”
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Improvement in kidney damage resulting from stanozolol intramuscular injections in rats by Natural Cocoa Powder (NCP) administration by Daniel Odoom, Benjamin Arko-Boham, Kevin Kofi Adutwum-Ofosu, Richard Michael Blay, Saviour Kweku Adjenti, John Ahenkorah, Bismarck Afedo Hottor, Esther Dennis, Nii Koney-Kwaku Koney, Frederick Kwaku Addai

“…Background: Stanozolol, an anabolic steroid, has been shown to induce kidney damage through mechanisms involving oxidative stress and inflammation. …”
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The Influence of the Seasonal Variability of <i>Candida</i> spp. Bloodstream Infections and Antifungal Treatment: A Mediterranean Pilot Study by Paola Di Carlo, Nicola Serra, Ornella Collotta, Claudia Colomba, Alberto Firenze, Luigi Aprea, Salvatore Antonino Distefano, Andrea Cortegiani, Giovanni Giammanco, Teresa Maria Assunta Fasciana, Roberta Virruso, Angela Capuano, Consolato M. Sergi, Antonio Cascio

“…<b>Background/Objectives</b>: Various factors associated with seasonality, including temperature, humidity, geographical composition, and seasonal fluctuations, can influence the trends of microbes responsible for hospital infections, such as <i>Candida</i> spp. …”
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Comparative Analysis of Fatty Acid Profiles in Erythrocyte Membranes in Vegetarians Compared to Omnivores by Marta Despotović, Jasmina Debeljak Martačić, Ivana Šarac, Gordana Petrović Oggiano, Slavica Ranković, Petar Jovanović, Marija Takić

“…Background: The fatty acid profiles in cellular membranes can be influenced by many endogenic and external factors, including diet. …”
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GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy by Stephen E. Flaherty III, LouJin Song, Bina Albuquerque, Anthony Rinaldi, Mary Piper, Dinesh Hirenallur Shanthappa, Xian Chen, John Stansfield, Shoh Asano, Evanthia Pashos, Trenton Thomas Ross, Srinath Jagarlapudi, Abdul Sheikh, Bei Zhang, Zhidan Wu

“…ABSTRACT Background Primary mitochondrial myopathies (PMMs) are disorders caused by mutations in genes encoding mitochondrial proteins and proteins involved in mitochondrial function. …”
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The Impact of Vaccination on Disease Course and Outcome in Intensive Care Patients With COVID-19 by B. I. Kurilin, V. Y. Kiselevskaya-Babinina, Y. V. Kuzmicheva, A. V. Shapoval, N. E. Drozdova, K. A. Popugayev

“…BACKGROUND Our study provides a unique opportunity to compare the course of the disease with a new coronavirus infection in seriously ill patients in the groups of vaccinated and unvaccinated patients hospitalized in the infectious intensive care units of N.V. …”
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Effects of a Western Diet on Colonic Dysbiosis, Bile Acid Dysmetabolism and Intestinal Inflammation in Clinically Healthy Dogs by Brandon Mason, Dipak Kumar Sahoo, Chelsea A. Iennarella‐Servantez, Aarti Kathrani, Shannon M. Morgan, Agnes Bourgois‐Mochel, Alex M. Bray, Vojtech Gabriel, Christopher Zdyrski, Jennifer M. Groeltz, Eric Cassmann, Mark R. Ackermann, Jan S. Suchodolski, Jonathan P. Mochel, Karin Allenspach, Albert E. Jergens

“…Animals Ten adult clinically healthy dogs. Methods A dietary trial compared the effects of two home‐prepared diets: a high‐fiber, low‐fat control diet (CD) to a diet containing the macronutrient composition of WD (low‐fiber, high fat). …”
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