School-based physical activity and health-related fitness in Mediterranean students: findings from the DELICIOUS project by Mohamed Aly, Achraf Ammar, Achraf Ammar, Achraf Ammar, Khaled Trabelsi, Khaled Trabelsi, Khaled Trabelsi, Liwa Masmoudi, Noha El-Gyar, Amira M. Shalaby, Osama Abdelkarim

“…BackgroundPhysical inactivity among children is a growing public health concern, particularly in Mediterranean countries, where lifestyle changes have contributed to declining physical fitness levels. …”
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Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…Abstract Background Preterm birth (PTB) is a major contributor to neonatal morbidity, mortality, and long-term health complications. …”
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A qualitative exploration of active ingredients and mechanisms of action of an online singing programme with mothers experiencing postnatal depression during the COVID-19 pandemic:... by Alexandra Burton, Rebecca H. Bind, Rachel Davis, Lorna Greenwood, Ching Yin Lee, Carolina Estevao, Katie Hazelgrove, Celeste Miller, Kristi Priestley, Lavinia Rebecchini, Tim Osborn, Hannah Dye, Paola Dazzan, Anthony Woods, Nikki Crane, Carmine M. Pariante, Daisy Fancourt

“…Abstract Background Social distancing restrictions and the suspension of in-person treatment and support contributed to an increase in postnatal depression during the coronavirus disease 2019 (COVID-19) pandemic. …”
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Ecological drivers of malaria vector habitat and transmission over 1 year of long-lasting insecticidal net intervention in Côte d’Ivoire by Benoit Talbot, Ludovic P. Ahoua Alou, Alphonsine A. Koffi, Colette Sih, Edouard Dangbenon, Marius G. Zoh, Soromane Camara, Serge B. Assi, Raphael N’Guessan, Louisa A. Messenger, Natacha Protopopoff, Jackie Cook, Manisha A. Kulkarni

“…Abstract Background Malaria is a mosquito-borne parasitic disease that causes significant morbidity and mortality in at-risk populations, especially in children in sub-Saharan Africa. …”
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Maternal β-carotene addition has long-term effects on intestinal health of offspring chicks by Taiping Wang, Taiping Wang, Da Wan, Da Wan, Tianyu Ren, Ye Tao, Ye Tao, Min Wu, Xin Zheng, Xin Zheng

“…BackgroundMaternal dietary intervention utilizing complex additives rich in β-carotene has demonstrated the capacity to enhance embryonic intestinal development and influence microbial composition in offspring. …”
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Evaluation of seasonal variation, effect of extraction solvent on phytochemicals and antioxidant activity on Rosmarinus officinalis grown in different agro-ecological zones of Kiam... by Zelipha N. Kabubii, James M. Mbaria, Mbaabu P. Mathiu, John M. Wanjohi, Evans N. Nyaboga

“…Abstract Background Rosemary (Rosmarinus officinalis) is a commonly used culinary herb with great potential applications in the pharmaceutical, food, and cosmetics industries because of its reported bioactive phytochemicals and antioxidant properties. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Process improvements that reduce cell heterogeneity while increasing donor cell numbers with improved chondrogenic potential during expansion culture are needed to realize the full potential of MSC therapy. Methods In this study, we investigated the potential of MSC metabolic modulation during expansion to enhance their chondrogenic commitment by varying the nutrient composition, including glucose, pyruvate, glutamine, and ascorbic acid in culture media. …”
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Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer by Tetsuya Isaka, Takuya Nagashima, Kota Washimi, Haruhiro Saito, Hiroto Narimatsu, Shunsuke Shigefuku, Chiaki Kanno, Ryotaro Matsuyama, Naoko Shigeta, Yui Sueishi, Hiroyuki Ito

“…ABSTRACT Background The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early‐stage lung cancer remains unclear. …”
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Exogenous Nucleotides Supplementation Attenuates Age‐Related Sarcopenia by Xin Wu, Rui Liu, Na Zhu, Xiujuan Wang, Chan Wei, Xiaoyang An, Meihong Xu, Yong Li

“…ABSTRACT Background Sarcopenia, an age‐related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. …”
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Investigation of differential Multi-Mode antibacterial mechanisms of essential oils of Satureja montana L. and Leptospermum scoparium J.R.Forst. & G.Forst. Against Porphyromonas gi... by Yue Yuan, Xiuli Hui, Zixuan Liu, Jinlong Sun, Rifat Nowshin Raka, Junsong Xiao, Zhongwei Zhang, Hua Wu

“…Abstract Background Globally, according to WHO estimates, severe periodontitis affects over 1 billion people. …”
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Immune cell topography of head and neck cancer by Bernard A Fox, Rieneke van de Ven, Carmen Ballesteros-Merino, Tara Muijlwijk, Sonja H Ganzevles, Ruud H Brakenhoff, Jos B Poell, Dennis N L M Nijenhuis, C René Leemans, Laura A N Peferoen, Elisabeth Bloemena, Fatima Ekhlas

“…Background Approximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. …”
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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation by Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

“…However, it remains unknown whether and how FPHA affects the immune microenvironment of the bone defects. Methods FPHA was synthesized and its composition and structural properties were confirmed. …”
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Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…Abstract Background Bipolar disorder (BD) is a heterogeneous psychiatric condition characterized by distinct episodes: manic (BipM), depressive (BipD), mixed (mBD), and remission (rBD). …”
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A study on the mechanism of Bushen Kaiqiao Formula in modulating microglial activation to alleviate neuroinflammation in ADHD by Jiaqi Zhang, Ruxin Sun, Yu Xiong, Yuting Yang, Jing Wang, Kanglin Zhu, Xinqiang Ni, Min Huang

“…Utilizing spontaneously hypertensive rats—a well-validated animal model of ADHD—this study aimed to characterize ADHD-like behavioral phenotypes and prefrontal cortical neuronal development and elucidate the neuroimmunological mechanisms through which the Bushen Kaiqiao Formula (BSKQF) exerts its therapeutic effects by modulating microglial activation states. Methods: Ultra-high-performance liquid chromatography coupled with a tandem mass spectrometer (UHPLC-MS/MS) was used to qualitatively analyze the chemical composition of Bushen Kaiqiao Formula, and network pharmacology was applied to predict its potential therapeutic targets and ADHD-related pathways ADHD-like behaviors, including hyperactivity, impulsivity, spatial memory, and attention, were assessed using the Open Field Test, Elevated Plus Maze, and Y-Maze Test at weeks 2 and 4. …”
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Fermented palm kernel waste with different sugars as substrate for black soldier fly larvae by R.A. Nugroho, R. Aryani, E.H. Hardi, H. Manurung, R. Rudianto, W.N. Jati

“…BACKGROUND AND OBJECTIVES: The palm industry generates several waste products. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Abstract Background Pancreatic carcinoma (PC) remains one of the most aggressive malignancies that is often referred to as the “king of cancers” in clinic. …”
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Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial. by Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium

“…<h4>Background</h4>Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. …”
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ESTIMATION OF TENDENCIES IN THE HEIGHT OF THE SNOW COVERAT WEATHER STATIONS IN THE NORTHERN CAUCASUS by L. A. Kesheva

“…Introduction. Against the background of global warming observed in recent decades, changes in all climatic characteristics are taking place. …”
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Enhancing treatment outcomes after gynaecological cancer (ACUMEN): a randomised controlled exercise trial protocol by Vivian Chiu, Alexander Boytar, Brent Cunningham, Tina Skinner, Jane Turner, Debra Anderson, Asaduzzaman Khan, Tom Bailey, Janine Porter-Steele, Leonie Young, Haitham Tuffaha, Lewis Perrin, Andrea Garrett, Jeffrey Goh, Grace Rose, Briana Clifford, Sjaan Gomersall, Darren Korbie, Nicolas Constantin, Jackie Li, Alexandra Leigh McCarthy

“…Abstract Background Treatment for gynaecological cancer often entails challenges that negatively affect quality-of-life. …”
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