A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers by Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller

“…Abstract Background While high-grade serous ovarian cancer (HGSC) has proven largely resistant to immunotherapy, sporadic incidents of partial and complete response have been observed in clinical trials and case reports. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Abstract Background Alzheimer’s disease (AD) remains incurable, yet its long prodromal phase offers a crucial window for early intervention. …”
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Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Background and purposeIschemic stroke (IS) is the most common type of stroke, known for its high rates of morbidity, disability, mortality, and recurrence. …”
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Heat Adaptation Benefits for Vulnerable groups In Africa (HABVIA): a study protocol for a controlled clinical heat adaptation trial by Michaela Deglon, Chad Africa, Larske Marit Soepnel, Thandi Kapwata, Ama de-Graft Aikins, Kweku Bedu-Addo, Guy Howard, Estelle Victoria Lambert, Dale Elizabeth Rae, Martha Sibanda, Christopher Gordon, Mark New, Lara Ruth Dugas

“…Abstract Background Temperatures across Africa are expected to rise at up to twice the rate of mean global temperatures, posing significant health threats to vulnerable communities. …”
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Long‐Term Effects of High‐Intensity Aerobic Training on Metabolic Syndrome: An 8‐Year Follow‐Up Randomized Clinical Trial by Felix Morales‐Palomo, Alfonso Moreno‐Cabañas, Laura Alvarez‐Jimenez, Diego Mora‐Gonzalez, Ricardo Mora‐Rodriguez

“…ABSTRACT Background Metabolic syndrome (MetS) is a set of five cardiometabolic risk factors that typically worsen with age. …”
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AKR1B1 Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance by Seçil Demirkol Canlı, Güneş Güner, Aynur Işık, Branka Sosic‐Jurjevic, Aleksandra Djikic Rom, Esin Gülce Seza, Ömer Dizdar, Sandra Dragicevic, Aleksandra Nikolic, Aytekin Akyol, Sreeparna Banerjee

“…ABSTRACT Background AKR1B1, a member of the aldo‐keto reductase enzyme family involved in the polyol pathway of aldehyde metabolism, is aberrantly expressed in colorectal cancer (CRC). …”
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Youth Uptake of Digital Sexual and Reproductive Health Services Across Sociodemographic Groups (2018-2022): A Total Population Study from Stockholm, Sweden by Lovisa Hellsten, MPH, Viktor H. Ahlqvist, PhD, Anna M. Nielsen, RM, PhD, Gunnar Brandén, PhD, Anna Mia Ekström, MD, PhD, Kyriaki Kosidou, MD, PhD

“…Objective: To examine uptake of in-person and digital sexual and reproductive health (SRH) services among adolescents and young adults, quantify uptake across time, and explore whether the introduction of digital services affected the sociodemographic composition of users. Patients and Methods: This Swedish total population study included all Stockholm residents aged 12-22 years between January 1st 2018 and December 31st 2022. …”
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Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress by Wang Y, Chen T, Shi Z, Dong L, Li M, Peng B, Li Q, Pan R, Xiao S, Yang Q, Jiang N, Liu X, Hu Q, Chen Y

“…This study focused on the regulation of GTSs in intestinal homeostasis imbalance caused by microgravity.Methods: A hindlimb suspension (HLS) rat model was established to evaluate the intestinal protective effects of GTSs. …”
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Nutritional deficiency in patients with newly diagnosed diffuse large B-cell lymphoma Prevalence and approaches to correction by O. A. Obukhova, I. A. Kurmukov, A. A. Semenova, A. V. Lebedeva, A. S. Ivanova, N. Yu. Shagina

“…To assess the prevalence of nutritional deficiency, features of usual diet energy and protein composition in patients with diffuse large B-cell lymphoma who are starting antitumor treatment.Materials and methods. …”
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Effects of saffron-grape intercropping on saffron flower number and rhizosphere microbial community by Yuanyuan Tao, Guifen Zhou, Xingchang Zhang, Mengqing Feng, Liqin Li, Xiaodong Qian

“…In our study, we counted the number of saffron flowers in two cropping patterns (saffron monoculture and saffron-grape intercropping), and analyzed the microbial community diversity and composition using Illumina high-throughput sequencing methods based on 16 S and ITS amplicons. …”
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Curcumin supplementation accelerates high-altitude acclimatization, prevents polycythemia and modulates gut microbiota in male Han population: a randomized controlled trial by Jilei Hu, Hongmei Lang, Die Fan, Ting Wen, Jiaojiao Shi, Chunxiu Xiao, Yunming Li, Chao Kang, Peijie Shi, Peijie Shi, Lirong Shen, Ning Lin, Ning Lin, Ning Lin

“…BackgroundPrevious evidence showed that curcumin enhanced the oxygen supply efficiency of hemoglobin and alleviated acute plateau hypoxia injury in animal models. …”
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The role and mechanism of CHMP4C in poor prognosis and drug sensitivity of lung adenocarcinoma by Chuan Xu, Mingshan Liu, Yang Li, Xiaoyue Peng, Wei Zhou, Wan Zhang, Jingtao Zhang, Bentong Yu

“…Abstract Background Chromatin modified protein 4C (CHMP4C) is a charged polyvesicular protein (CHMP) that is involved in the composition of the endosomal sorting complex (ESCRT-III) required for transport III and promotes the necessary separation of daughter cells. …”
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Interval Hypoxic Training in Rehabilitation Program for Adolescents with Overweight / Obesity and Comorbid Arterial Hypertension: Open-Label Randomized Study by Alexandra V. Mashanskaya, Anna V. Pogodina, Alina V. Atalyan, Lyubov V. Rychkova, Olga V. Bugun, Anastasia V. Vlasenko, Tamara V. Mandzyak, Elena E. Khramova, Olga V. Kravtsova, Tatiana A. Astahova

“…Background. Searching for new strategies for the rehabilitation of adolescents with obesity and comorbid arterial hypertension (AHT) before significant pathological changes development in the cardiovascular system remains the urgent challenge. …”
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Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer by Eunkyung Han, Hye Yeon Choi, Hyun Jung Kwon, Yul Ri Chung, Hee-Chul Shin, Eun-Kyu Kim, Koung Jin Suh, Se Hyun Kim, Jee Hyun Kim, So Yeon Park

“…Abstract Background The tumor immune microenvironment, particularly tumor-infiltrating lymphocytes (TILs), plays a critical role in disease progression and treatment response in triple-negative breast cancers (TNBCs). …”
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Fatty pancreas disease in newly diagnosed type 2 diabetes patients: a case–control study on relationships with glycemic control and exocrine function by Tahsin Taner Karaevren, Refika Yorulmaz, Mahinur Cerit, Halit Nahit Şendur, Burak Kalafat, Gizem Yaz Aydın, Özlem Gülbahar, Mehmet Muhittin Yalçın, Ayhan Karakoç, Müjde Aktürk, Füsun Baloş Törüner, Alev Eroğlu Altınova, Taha Enes Çetin, Ethem Turgay Cerit

“…Abstract Background Fatty pancreas disease (FPD) is characterized by abnormal fat accumulation in pancreatic tissue and is often associated with obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). …”
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Tracking Coronavirus 2019 pandemic-related waste generation in urban waterways by R.G. Banal, I.L.M. Abad

“…BACKGROUND AND OBJECTIVES: The Coronavirus 2019 pandemic has revealed significant shortcomings in the Philippines’ solid waste management system, particularly in addressing the surge of pandemic-related waste. …”
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Hypertension and Elevated Pulse Pressure Responsive to Biomass Pollutants Exposures in Young Workers From the Democratic Republic of Congo: A Cross‐Sectional Analysis by Pierre Lofuta Olenga Vuvu, Malgorzata Klass, Nathalie Pauwen, Augustin Kipula, Silvia Perez Bogerd, Alain Van Muylem, Philippe Van de Borne, Gael Deboeck

“…Background Occupational biomass pollutant exposure as observed in charcoal workers may have significant cardiovascular effects. …”
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Combined microbial inoculation and reduced inorganic fertilization enhances diversity and functionality in potato rhizosphere microbiome at field scale by Irene Ollio, Raúl Zornoza, Josefa Contreras Gallego, Catalina Egea-Gilabert, Juan A. Fernández, Eva Lloret

“…Abstract Background Intensive potato farming heavily relies on mineral fertilizers which can be detrimental to the environment. …”
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Neuromuscular Electrical Stimulation to Maximize Hip Abductor Strength and Reduce Fall Risk in Older Veterans: Protocol for a Randomized Controlled Trial by Ben Friedman, Brock A Beamer, Jeffrey Beans, Vicki Gray, Gad Alon, Alice Ryan, Leslie I Katzel, John D Sorkin, Odessa Addison

“… BackgroundNearly half of all veterans are 65 years and older, and they have a higher prevalence of functional disabilities compared to the nonveteran population. …”
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Prevalence of urinary tract infections and antibiotic susceptibility patterns of bacterial isolates in first-time ANC attendees at a secondary health facility in Ghana: a cross-sec... by Kwame Opare-Asamoah, Ezekiel Kofi Vicar, Jerry Xola Sosu, Eunice Nyarko, Sulemana Zakariah Mustapha, Kanyite Ayisha Mumuni, Nana Kofi Yeboah Aboagye, Saeed F. Majeed, Philomena Ajanaba Asakeboba, Vida Nyagre Yakong, Kwadwo Fosu Antwi, Julius T. Dongdem

“…Abstract Background Urinary tract infections (UTIs) in pregnant women are a common public health concern. …”
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