Temporin A and Bombinin H2 Antimicrobial Peptides Exhibit Selective Cytotoxicity to Lung Cancer Cells by Lucy Swithenbank, Phillipa Cox, Llinos G. Harris, Edward Dudley, Kathryn Sinclair, Paul Lewis, Floriana Cappiello, Claire Morgan

“…Background. Recently, antimicrobial peptides (AMPs) have been investigated for their use in cancer therapy. …”
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Optical Characterization of Fluorescent Chitosan-Based Carbon Dots Embedded in Aqueous Natural Dye by Sthanley R. De Lima, Thiago V. Costa, Tácio T. S. Santos, Dora G. Felipe, Teófanes B. Serna, Acácio A. Andrade, Viviane Pilla

“…(1) Background: This work evaluated the optical characterization of aqueous fluorescent chitosan-based carbon dots (or carbon nanoparticles CNPs) embedded in natural dye for potential functional packaging applications. …”
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Inulin Diet Alleviates Abdominal Aortic Aneurysm by Increasing Akkermansia and Improving Intestinal Barrier by Shuang Guo, Fen Yang, Jiyu Zhang, Yuhan Liao, Ni Xia, Tingting Tang, Chaolong Wang, Qing K. Wang, Chen Chen, Desheng Hu, Zhilei Shan, Xiang Cheng

“…<b>Background/Objectives</b>: Previous studies have shown varying efficacy of high-fiber diets containing different ingredients in abdominal aortic aneurysms (AAAs). …”
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Microhardness, Structure, and Morphology of Primary Enamel after Phosphoric Acid, Self-Etching Adhesive, and Er:YAG Laser Etching by María del Carmen Zoila Alcantara-Galeana, Rosalía Contreras-Bulnes, Laura Emma Rodríguez-Vilchis, Manuel Eduardo Espinosa-Pesqueira, Cecilia Carlota Barrera-Ortega, Itzel Monserrat López-Hurtado, Adriana Fernández-Bobadilla

“…Background. Phosphoric acid is the traditional etching agent; self-etching adhesives and Er:YAG laser are alternative methods. …”
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Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer by Sofie Bosch, Animesh Acharjee, Mohammed Nabil Quraishi, Irene V Bijnsdorp, Patricia Rojas, Abdellatif Bakkali, Erwin EW Jansen, Pieter Stokkers, Johan Kuijvenhoven, Thang V Pham, Andrew D Beggs, Connie R Jimenez, Eduard A Struys, Georgios V Gkoutos, Tim GJ de Meij, Nanne KH de Boer

“…Background Screening for colorectal cancer (CRC) reduces its mortality but has limited sensitivity and specificity. …”
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Circulating immune cells exhibit distinct traits linked to metastatic burden in breast cancer by S. Mangiola, R. Brown, C. Zhan, J. Berthelet, S. Guleria, C. Liyanage, S. Ostrouska, J. Wilcox, M. Merdas, P. Fuge-Larsen, C. Bell, J. Schröder, L. A. Mielke, J. M. Mariadason, S. Chang-Hao Tsao, Y. Chen, V. K. Yadav, S. Vodala, R. L. Anderson, D. Merino, A. Behren, B. Yeo, A. T. Papenfuss, B. Pal

“…Abstract Background Circulating immune cells play a crucial role in the anti-tumour immune response, yet the systemic immune system in metastatic breast cancers is not fully characterised. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…BackgroundThe exploration of genetic signatures within the ovarian cancer (OC) tumor microenvironment (TME) remains limited. …”
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Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect by Jie Zheng, Yihui Liu, Yong He, Chen Hu, Di Wu, Tao Peng, Chao He, Rui Han, Conghua Lu, Ziyuan Gao, Daijuan Huang, Caiyu Lin, Yuanyao Dou, Yimin Zhang, Fenfen Sun, Weiling Jiang, Guoqing Yin

“…Background The dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in the therapeutic trajectory of non-small cell lung cancer (NSCLC). …”
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Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma by Akihiko Kawahara, Jun Akiba, Hirohisa Yano, Ambrogio Fassina, Rocco Cappellesso, Yoshiki Naito, Maria Guido, Paolo Simioni, Giuliana Cortese, Lorenzo Nicolè, Tiziana Sanavia, Valeria Maffeis, Claudia Maria Radu, Davide Serafin, Giacomo Zanus

“…Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. …”
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Visceral adiposity loss is associated with improvement in cardiometabolic markers: findings from a dietary intervention study by Shazana Rifham Abdullah, Ahmad Kamil Nur Zati Iwani, Liyana Ahmad Zamri, Ruziana Mona Wan Mohd Zin, Norhashimah Abu Seman, Nur Azlin Zainal Abidin, Siti Sarah Hamzah, Nur Hayati Azizul, Azahadi Omar, Zamtira Seman, Abqariyah Yahya, Mohd Fairulnizal Md Noh

“…BackgroundVisceral adiposity is closely linked with cardiometabolic disorders, but evidence on the extent of visceral fat loss required for significant improvement in cardiometabolic markers remains limited. …”
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Coral microbiome in estuary coral community of Pearl River Estuary: insights into variation in coral holobiont adaptability to low-salinity conditions by Mengling Lan, Kaixiang Gao, Zhenjun Qin, Zhanhong Li, Ru Meng, Lifei Wei, Biao Chen, Xiaopeng Yu, Lijia Xu, Yongzhi Wang, Kefu Yu

“…Abstract Background Low salinity is a crucial environmental stressor that affects estuarine coral ecosystems considerably. …”
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Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus by Jingxuan Qiu, Yiwen Wei, Jiayi Shu, Wenjing Zheng, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Sijie Wang, Xuanyi Wang, Tianyi Qiu

“…Abstract Background Norovirus (NoVs) is a foodborne pathogen that causes acute gastroenteritis. …”
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The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and ratsResearch in context by Rune Ehrenreich Kuhre, Borja Ballarín-González, Christian Lehn Brand, Tine Glendorf, Kim Grimstrup Madsen, Karina Rahr Hjøllund, Wouter Frederik Johan Hogendorf, David Højland Ipsen, Sofia Lundh, Thomas Kruse, Signe Beck Petersen, Anna Secher, Andreas Vegge, Kirsten Raun

“…Summary: Background: Amycretin is a novel unimolecular glucagon-like peptide-1 (GLP-1) and amylin receptor agonist. …”
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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…Background Chimeric antigen receptor (CAR)-T cells face many obstacles in solid tumor therapy, including heterogeneous antigen expression and inefficient T cell persistence. …”
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Prevalence and Clinical Impact of Obstructive Sleep Apnea in Patients with Severe Aortic Stenosis Undergoing Valve Replacement by Hilary Miranda-Mendoza, Luis M. Amezcua-Guerra, Gustavo Rojas-Velasco, Daniel Manzur-Sandoval, Jennifer Escobar-Alvarado, Luis Chávez-Sánchez, Wendy G. Vázquez-González, Laura L. Rodríguez Chávez, Humberto Martínez Hernández, Malinalli Brianza-Padilla

“…<b>Background/Objectives</b>: Aortic stenosis (AS) is the most prevalent valvular disease among older adults. …”
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Orange Peel <i>Lactiplantibacillus plantarum</i>: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity by Elisa Corazza, Asia Pizzi, Carola Parolin, Barbara Giordani, Angela Abruzzo, Federica Bigucci, Teresa Cerchiara, Barbara Luppi, Beatrice Vitali

“…<b>Background/Objectives:</b> Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. …”
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PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease by Yixian Ma, Yixian Ma, Yixian Ma, Jinshan Suo, Siqi Sheng, Siqi Sheng, Siqi Sheng, Ling Chen, Ling Chen, Ling Chen, Ling Chen

“…As an essential immune checkpoint, Programmed death-ligand 1 (PD-L1) has been implicated in modulating gut microbiota composition. However, the precise role of PD-L1 in shaping metagenomic profiles during IBD-associated colitis remains unexplored.MethodsDSS-induced colitis was established in both PD-L1 knockout (Pdcd1lg1-/-) mice and wild-type (wt) control mice. …”
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Progression to fibrosis and hepatocellular carcinoma in DEN CCl4 liver mice, is associated with macrophage and striking regulatory T cells infiltration by Ananya Ajith, Jonathan Evraerts, Caroline Bouzin, Davide Brusa, Makram Merimi, Mehdi Najar, Mehdi Najar, Françoise Smets, Etienne Sokal, Mustapha Najimi

“…This study investigates immune dysregulation that occurs during the progression of CLD to HCC by delineating changes in immune cell composition and distribution within the liver microenvironment.MethodsMice were injected with Diethylnitrosamine (DEN) at 4 weeks of age, followed by continuous tri-weekly injections of carbon tetrachloride (CCl4) for 6 and 21 weeks to induce liver fibrosis and HCC. …”
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Evaluation of the immunomodulatory effects of a novel synbiotic made of combined use of probiotic-prebiotic-Chinese traditional herbs by Deshan Ning, Yiru Huang, Yulong Zhou, Hongwei Zhao, Wenlei Nie, Yu Zheng, Xiaojun Huang

“…Background: Recent studies have discussed the preferred activity of synbiotics, which are a combination of probiotics and prebiotics. …”
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Bonding super translucent multilayered monolithic zirconia to different foundation materials: an invitro study by Noha Essam, Shaimaa Ahmed Abo-Elfarag, Ahmed Attia

“…Conclusion Sandblasting with priming is recommended as a monolithic zirconia surface treatment method. Dentin is the most reliable substrate followed by composite.…”
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