Lower respiratory tract co-infection of Streptococcus pneumoniae and respiratory syncytial virus shapes microbial landscape and clinical outcomes in children by Xiaoran Yu, Xiaoran Yu, Xuemei Yang, Yiqin Song, Jie Yu, Tingting Jiang, He Tang, Xiaoxuan Yang, Xi Zeng, Jing Bi, Adong Shen, Adong Shen, Lin Sun

“…BackgroundLower respiratory tract infections (LRTI), which are most commonly caused by Streptococcus pneumoniae (SP) and respiratory syncytial virus (RSV), pose a substantial global health burden in children. …”
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Characteristic alterations of gut microbiota and metabolites in patients with perianal abscess: a multi-omics analysis by Huangfu Ma, Jingjing Fang, Mengjie Li, Yige Qin, Yanmei Wang, Seong-Gook Kang, Kunlun Huang, Kunlun Huang, Kunlun Huang, Tao Tong, Tao Tong, Tao Tong

“…Background/objectivesVarious studies have highlighted the important associations between perianal abscess (PA) and gut microbiota and related metabolites. …”
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The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Despite global advances in asthma control, little attention has been paid to the evolving composition and geographic disparity of modifiable risk factors in this age group.MethodsWe utilized data from the Global Burden of Disease Study 2021 to evaluate the long-term trends (1990–2021) in asthma burden attributable to high body-mass index (BMI), smoking, and occupational asthmagens among adults aged 60 years and older. …”
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Biomarkers of GH deficiency identified in untreated and GH-treated Pit-1 mutant mice by Sarmed Al-Samerria, Huiting Xu, M. Elena Diaz-Rubio, Joseph Phelan, Chi Su, Keer Ma, Anna Newen, Kiana Li, Sayaka Yamada, Ariel L. Negron, Fredric Wondisford, Sally Radovick

“…This study aimed to identify metabolic biomarkers of GHD and assess their responsiveness to GH therapy, alongside pathway analysis to uncover disrupted metabolic pathways.MethodsThe Pit-1^K216E mouse model was validated for GHD through assessments of GH production, growth, and body composition. …”
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Mitochondrial Sensitivity to Submaximal [ADP] Following Bed Rest: A Novel Two‐Phase Approach Associated With Fibre Types by Lucrezia Zuccarelli, Maria De Martino, Antonio Filippi, Alice E. Knapton, Benjamin D. Thackray, Giovanni Baldassarre, Boštjan Šimunič, Rado Pišot, Giuseppe Sirago, Elena Monti, Marco Narici, Miriam Isola, Andrew J. Murray, Giovanna Lippe, Bruno Grassi

“…The aim of this study was to evaluate mitochondrial sensitivity to submaximal [ADP] by an alternative approach aimed at identifying responses associated with fibre type composition. Methods Isolated permeabilized vastus lateralis fibres were analysed by high‐resolution respirometry in 9 young males before and after a 10‐day horizontal bed rest. …”
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Celecoxib Enhances Oxidative Muscle Fibre Formation and Improves Muscle Functions Through Prokr1 Activation in Mice by Jeong Hwan Park, Jongsoo Mok, Seoah Park, Dooho Kim, Min‐Su Kang, Tae Sub Park, Joonghoon Park

“…ABSTRACT Background Muscle diseases are serious challenges to human health. …”
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Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…BackgroundChemoradiotherapy (CRT) is the primary and most effective treatment for non-metastatic nasopharyngeal carcinoma (NPC), exerting antitumor effects by modulating immune cells. …”
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CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium by Huang S, Pan L, Li M, Pang S, Tian Y, Shi W, Zong Y, Zhang D, Tian D

“…However, the exact mechanisms remain unclear.Methods: We applied a DSS-induced colitis model in wild-type and perforin-deficient (Prf1−/−) mice. …”
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Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma by Chen Ni, Rulin Hua, Yuanyuan Yang, Jialu Liang, Wentao Liu, Linlin Wang, Xiaohan Yao, Anqi Li, Long Yu, Ruo Feng, Dekang Lv, Zhihai Qin, Wenlong Zhai

“…Abstract Background Extrahepatic cholangiocarcinoma (eCCA) is a rare but refractory cancer with dense desmoplasia. …”
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Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

“…Background & Aims: Cellular heterogeneity of innate immune cells, such as macrophages, in the liver is a hallmark of metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis. …”
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Consistent sleep onset and maintenance of body weight after weight loss: An analysis of data from the NoHoW trial. by Sofus C Larsen, Graham Horgan, Marie-Louise K Mikkelsen, Antonio L Palmeira, Sarah Scott, Cristiana Duarte, Inês Santos, Jorge Encantado, Ruairi O'Driscoll, Jake Turicchi, Joanna Michalowska, R James Stubbs, Berit L Heitmann

“…<h4>Background</h4>Several studies have suggested that reduced sleep duration and quality are associated with an increased risk of obesity and related metabolic disorders, but the role of sleep in long-term weight loss maintenance (WLM) has not been thoroughly explored using prospective data.…”
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Distribution characteristics of bacterial communities in central air-conditioning ventilation systems of a Grade 3A hospital in Shanghai based on 16S rRNA sequencing by Jun NI, Haiyun ZHANG, Jian CHEN, Lijun ZHANG, Yongping LIU, Xiaojing LI, Yiming ZHENG, Liping ZHANG

“…BackgroundA diverse cohort of patients and susceptible individuals congregate in healthcare facilities, where exposure to pathogenic microorganisms associated with respiratory infectious diseases constitutes a significant risk factor for cross-infection. …”
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Short‐chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice by Chaoran Liu, Pui Yan Wong, Qianjin Wang, Hei Yuet Wong, Tao Huang, Can Cui, Ning Zhang, Wing Hoi Cheung, Ronald Man Yeung Wong

“…Abstract Background Sarcopenia is a prevalent muscle disorder in old people leading to higher fracture rate, mortality, and other adverse clinical outcomes. …”
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Associations between Hypertriglyceridemia and Circulating Neutrophil Subpopulation in Patients with Dyslipidemia by Vadim Genkel, Ilya Dolgushin, Irina Baturina, Albina Savochkina, Alla Kuznetsova, Lubov Pykhova, Igor Shaposhnik

“…Background. There is strong evidence to suggest that the negative influence of triglyceride-rich lipoproteins (TRLs) on atherosclerosis development and progression is at least partially mediated by their proinflammatory effects. …”
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The Role of Ultrasound as a Predictor of Malignancy in Indeterminate Thyroid Nodules—A Multicenter Study by Reem J. Al Argan, Dania M. Alkhafaji, Feras M. Almajid, Njoud K. Alkhaldi, Zahra A. Al Ghareeb, Moutaz F. Osman, Manal A. Hasan, Safi G. Alqatari, Abrar J. Alwaheed, Fatima E. Ismaeel, Reem S. AlSulaiman

“…<i>Background and Objectives:</i> Indeterminate thyroid nodules (Bethesda III and IV) are a common clinical entity that present a diagnostic challenge due to their intermediate risk of malignancy. …”
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Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial by Yiran Guan, Ruixin Zhu, Wen Zhao, Langrun Wang, Li You, Zhaozhong Zeng, Qiuyue Jiang, Zeyang Zhu, Jiayu Gou, Qi Zhang, Jie Guo, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang, Ran Wang, Jingjing He

“…BackgroundGlobally, master’s and doctoral students, especially pregraduate students, are under great pressure. …”
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Peroperative evaluation of vascularity of various flaps by fluorescein technique by V Bhattacharya, Goyal Sunish, Sanjib Singh Nepram, H Singh Manihar, Adil Bashir Sheikh

“…Aims: This study deals with experimental and clinical efficiency of fluorescein dye technique to evaluate the vascularity of flaps of various compositions. Materials and Methods: The experimental study was conducted on rats to standardize the technique. …”
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Chromatin Phenotype Karyometry Can Predict Recurrence in Papillary Urothelial Neoplasms of Low Malignant Potential by Rodolfo Montironi, Marina Scarpelli, Antonio Lopez-Beltran, Roberta Mazzucchelli, David Alberts, James Ranger-Moore, Hubert G. Bartels, Peter W. Hamilton, Janine Einspahr, Peter H. Bartels

“…Background: A preceding exploratory study (J. Clin. …”
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Petrochemistry and mineralogy of pumice from the Sarychev Peak Volcano, Matua Island, Central Kuril Island by V. M. Okrugin, E. D. Skilskaia, S. V. Moskaleva

“…To reconstruct the compositions of magmatic melts of a caldera-forming eruption of the proto-Matua volcano.Materials and methods. …”
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Numerical Simulation Study on Stability Control Technology of Large-Area Wall Caving Area (LAWCA) in Large-Inclined Face by Xun Liu, Shihao Tu, Hongsheng Tu, Long Tang, Jieyang Ma, Yan Li, Wenlong Li, Kaijun Miao, Hao Tian

“…After mining, the caving rock mass rolls to the lower part of the working face due to gravity, and the caving compaction characteristics of the working face are different from those of the flat and gently inclined working face, taking Huainan Xinji No. 2 Mine 211112 high-angle composite roof working face large-area gang roof fall area as the engineering background. …”
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