The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens by Renata S. Fernandes, Gabriela de Assis Burle-Caldas, Sarah Aparecida Rodrigues Sergio, Ana Flávia Bráz, Nathália Pereira da Silva Leite, Milton Pereira, Juliana de Oliveira Silva, Natália Satchiko Hojo-Souza, Bianca de Oliveira, Ana Paula S. Moura Fernandes, Flávio Guimarães da Fonseca, Ricardo Tostes Gazzinelli, Diego dos Santos Ferreira, Santuza M. Ribeiro Teixeira

“…Results Using firefly luciferase (Luc) as a reporter mRNA, we evaluated the physical–chemical properties, stability, and biodistribution of an LNP-mRNA formulation produced using a novel lipid composition and a microfluidic organic-aqueous precipitation method. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…In this study, we investigated the intricate mechanisms through which SM polyherbal extract exerts neuroprotective and anxiolytic effects in cultured HT-22 cells and rodent models. Method: In this study, the chemical composition of SM was first identified using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). …”
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Dracaena trifasciata (Prain) Mabb leaf extract protects MIN6 pancreas-derived beta cells against the diabetic toxin streptozotocin: role of the NF-κB pathway by Christiaan Warner Hoornenborg, Christiaan Warner Hoornenborg, Nur Qomariyah, Nur Qomariyah, Herson Antonio González-Ponce, André Petrus Van Beek, Han Moshage, Gertjan Van Dijk

“…This in vitro study evaluated whether and how a leaf extract of ST could directly protect pancreas-derived MIN6 cells against the diabetogenic toxin streptozotocin (STZ).MethodsComposition of the ST extract (by 100% methanol) was investigated using high resolution mass spectrometry, which revealed several compounds with beneficial bioactive efficacy. …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…Intranasal immunization has emerged as a more effective method of inducing local immune responses against cancer cells in the lungs.Methods: An innovative layered double hydroxide- and 5-OP-RU–based mRNA nanovaccine (Mg/Al LDH-5-OP-RU/mRNA) was synthesized via coprecipitation. …”
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Urolithiasis complicated by chronic obstructive pyelonephritis in patients with concomitant diseases of the cardiovascular system by R. V. Royuk, S. K. Yarovoy, R. A. Khomov

“…To study the features of chronic obstructive pyelonephritis in patients with recurrent nephrolithiasis and concomitant diseases of the cardiovascular system.Materials and methods. The study included a total of 618 patients suffering from recurrent nephrolithiasis complicated by ChOP. …”
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TO THE ISSUE OF INDICATORS OF BIOLOGICALLY VALUABLE FORESTS IN PROTECTED AREAS by Angelika A. Gaivoronslaya, Marina V. Dolganova, Vladimir T. Demikhov, Olga N. Chigrai, Dmitry I. Chuchin

“…Background. Work on biomonitoring of biologically valuable forests, including those belonging to the international category of «forests of high conservation value», is relevant, especially in the old developed region, and is also poorly studied in terms of monitoring. …”
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The gut microbiome and metabolome in kidney transplant recipients with normal and moderately decreased kidney function by Yang Lan, Duo Wang, Jiayang He, Hongji Yang, Yifu Hou, Wenjia Di, Hailian Wang, Xiangwei Luo, Liang Wei

“…CKD-T can be affected by the microbial composition and metabolites. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of CKD-T.Methods We collected 100 fecal samples of KTRs and divided them into two groups according to the stage progression of CKD-T. …”
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Esophageal microbiome correlates with post-esophagectomy anastomotic leak in cancer patients by R. Naddaf, H. Shmilovich, S. Carasso, R. Keshet-David, R. Herren, T. Gefen, T. Goshen-Lago, Y. Zwang, I. Livyatan, N. Shental, O. Haberfeld, R. Straussman, S.R. Markar, M. Nilsson, H. Kashtan, I. Ben-Aharon, N. Geva-Zatorsky

“…Background: Despite continuous improvement in long-term survival after esophagectomy, potential serious post-operative complications, such as anastomotic leaks (ALs), still occur. …”
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Chronic Heat Stress Can Induce Conjugation of a Novel <i>ermB</i>-Containing ICE_FZMF, Increasing Resistance to Erythromycin Among <i>Enterococcus</i> Strains in Diverse... by Lingxian Yi, Zining Ren, Yu Feng, Yechun Zhang, Jianshuo Liu, Xiaowu Yuan, Qihong Kuang, Hui Deng, Bo Yang, Daojin Yu

“…Background: The impact of heat stress on intestinal bacterial antimicrobial resistance (AMR) and its underlying mechanisms is not fully understood. …”
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Larvicidal Potential of <i>Trattinnickia Burserifolia</i> Mart. Essential Oil in Controlling the Malaria Vector in the Amazon by Gisele Guimarães de Oliveira, Stherfany Mac Donald da Silva, Alessandro Pereira de Souza, Leticia Vieira Anchieta da Silva, Anauara Lima e Silva, Ana Cristina Gonçalves Reis de Melo, Rosemary Aparecida Roque, André Correa de Oliveira, Antonio Alves de Melo Filho, Andreimar Martins Soares

“…<b>Objectives</b>: This study investigates the larvicidal activity of <i>Trattinnickia burserifolia</i> Mart. essential oil against <i>Anopheles darlingi</i>. <b>Methods</b>: The essential oil was obtained through hydrodistillation, and its chemical composition was identified using gas chromatography–mass spectrometry. …”
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Chemical Profiling and Assessment of Analgesic and Anti-Inflammatory Activity of <i>Ammoides verticillata</i> Essential Oil: In Vitro, In Vivo, and In Silico Studies by Imene Derardja, Redouane Rebai, Fethi Benbelaïd, Luc Jasmin, Abdennacer Boudah, Mohammed Esseddik Toumi, Salsabil Mebarki, Fethi Farouk Kebaili, Leila Bellebcir, Alain Muselli

“…<b>Methods</b>: The chemical composition of AVEO was determined using GC-MS analysis, and antioxidant capacity was assessed through in vitro assays. …”
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The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial by Barbara Franović, Marija Čandrlić, Marko Blašković, Ira Renko, Katarina Komar Milas, Elitza Petkova Markova-Car, Bojana Mohar Vitezić, Dragana Gabrić, Ivana Gobin, Sabina Mahmutović Vranić, Željka Perić Kačarević, Olga Cvijanović Peloza

“…Background: Understanding microbial colonization on different membranes is critical for guided bone regeneration procedures such as socket preservation, as biofilm formation may affect healing and clinical outcomes. …”
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Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…BackgroundHypertension is a significant risk factor for cardiovascular disease, and acupuncture has demonstrated therapeutic effects in managing hypertension. …”
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Saccharomyces boulardii (CNCM I-745) improves intestinal damage in sepsis by remodeling intestinal flora structure by Hui-Ying Liu, Yao Li, Yi-Lu Lin, Yu-Jia Tang, Jin-Da Zhao, Jia Xu, Kuo Wang, Ying-Fei Zhi, Yan Zhang, Jia-Le Deng, Kai Kang, Ying Chen, Yang Gao

“…BackgroundSepsis is one of the leading causes of mortality among intensive care unit (ICU) patients. …”
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Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study by Asieh Mansour, Sayed Mahmoud Sajjadi-Jazi, Maryam Mirahmad, Pooria Asili, Maryam Sharafkhah, Sahar Masoudi, Hossein Poustchi, Akram Pourshams, Maryam Hashemian, Azita Hekmatdoost, Reza Malekzadeh

“…Abstract Background Less is known whether the amino acid composition of dietary protein sources effects on long-term health outcomes. …”
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Effects of different grain types on nutrient apparent digestibility, glycemic responses, and fecal VFA content in weaned foals by Xinxin Huang, Qian Li, Xuanyue Li, Chao Li, Jiahao Li, Linjiao He, Hongxin Jing, Fan Yang, Xiaobin Li

“…This study examines the impact of diets incorporating steam-flaked grains (corn, oats, and barley) on apparent nutrient digestibility, glycemic response, and fecal volatile fatty acid (VFA) composition in the weaned Kazakh foals. Methods Eighteen male Kazakh foals, weaned at 5 months, were randomly assigned to three groups (n = 6 per group) based on grain type: corn group (CG), oats group (OG), and barley group (BG). …”
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Association of PM2.5 and its elemental components with plasma metabolome in healthy older adults: Evidence from epidemiological and experimental studies by Quan Zhou, Liangping Chen, Chenzhou He, Xiaoying Liu, Wenli Wang, Shuling Kang, Yu Jiang, Jianjun Xiang, Xiaoyang Zhang, Chuancheng Wu

“…Background: Previous studies have found that exposure to fine particulate matter (PM2.5) is associated with metabolic alterations, but the specific effects of its composition on metabolic changes remain unclear. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Abstract Background Pituitary neuroendocrine tumors (PitNET) are among the most common intracranial tumors. …”
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Western Experience of Hepatolithiasis: Clinical Insights from a Case Series in a Tertiary Center by Natale Calomino, Ludovico Carbone, Engjell Kelmendi, Stefania Angela Piccioni, Gianmario Edoardo Poto, Giulio Bagnacci, Luca Resca, Annalisa Guarracino, Sergio Tripodi, Bina Barbato, Stefano Brillanti, Franco Roviello, Gian Luigi Adani, Daniele Marrelli

“…<i>Background and Objectives</i>: Hepatolithiasis (HL), or intrahepatic bile duct stone disease, shows regional variation and is a rare condition in Western countries. …”
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The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial by Chahrazed Mekadim, Jakub Mrazek, Kateřina Olša Fliegerová, Hana Sechovcová, Tiziana Maria Mahayri, Radka Jarošíková, Jitka Husáková, Veronika Wosková, Petr Tůma, Jan Polák, Dominika Sojáková, Andrea Němcová, Michal Dubský, Vladimíra Fejfarová

“…Abstract Background Diabetic foot infections (DFIs) contribute to the global disability burden. …”
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