Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution by Min Zhao, Weichen Song, Shunying Yu, Wenxiang Cai, Guan Ning Lin

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Use of 18F-NaF PET in the staging of skeletal metastases of newly diagnosed, high-risk prostate cancer patients: a nationwide cohort study by Christian Torp-Pedersen, Mette Nørgaard, Helle D Zacho, Lars J Petersen, Anna Winther Mogensen, Marie T Pank

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Virtual online consultations: advantages and limitations (VOCAL) study by Trisha Greenhalgh, Joe Wherton, Sara Shaw, Charles Gutteridge, Emma Byrne, Isabel Hodkinson, Shanti Vijayaraghavan, Desirée Campbell-Richards, Satya Bhattacharya, Philippa Hanson, Seendy Ramoutar, Anna Collard, Joanne Morris

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Which unmet social care needs have the biggest impact on healthy ageing? An analysis of data from the English Longitudinal Study of Ageing by Barbara Hanratty, Gemma F Spiers, David Sinclair, Andrew Kingston, Michelle M C Tan, Laurie E Davies

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Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study by Lehana Thabane, Lawrence Mbuagbaw, Michael Paterson, Laura Targownik, Mei Wang, Anne Holbrook, Deborah Siegal

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Identification of individual-level clinical factors associated with increased risk of death during heatwaves: a time-stratified case-crossover study using national primary care rec... by Shakoor Hajat, Ross Thompson, Sari Kovats, Emer O’Connell, Helen Macintyre

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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

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Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study by Yoshiya Tanaka, Yosuke Okada, Tetsuya Kawahara, Gen Suzuki, Tetsuya Inazu, Shoichi Mizuno, Fumiyoshi Kasagi

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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

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Health literacy in medication communication during hospital discharge: a qualitative study at an internal medicines ward in Norway by Liv Mathiesen, Morten Mowé, Yvonne Andersson, Stine Eidhammer Rognan, Kajsa Rebecka Bengtsson, Helene Berg Lie, Sofia Kälvemark Sporrong

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Characteristics of eye injuries, medical cost and return-to-work status among industrial workers: a retrospective study by Rokiah Omar, Nur Syamilah Anan, Izmel Azim Azri, Chiranjib Majumder, Victor Feizal Knight

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Perceived social support and the experience of intimate partner violence among married and cohabiting young women in urban slums, Ibadan, Nigeria: a descriptive study by Olufunmilayo I Fawole, Omowumi O Okedare

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Evaluating the implementation of a multicomponent intervention to improve faecal immunochemical test-based (FIT) colorectal cancer screening in primary care by Kamala Adhikari, James Whitworth, Gary F Teare, Muhammad Kashif Mughal, Danica Hignell, Barbara Moysey, Jawad Chishtie

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Factors influencing utilisation of services provided by community midwives and their non-retention in district Thatta, Pakistan: a qualitative study protocol by Anam Shahil Feroz, Sarah Saleem, Bakhtawar M Hanif Khowaja

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Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China by Yong-Jun Wang, Xin Yang, Qi Zhou, Hao Li, Xia Meng, Yong Jiang, Li-Ping Liu, Yi-long Wang, Hong-Qiu Gu, Zi-Xiao Li, Xing-Quan Zhao, Chun-Juan Wang, Chelsea Liu, Hai-yan Wang, Ying-Yu Jiang

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Assessment of economic burden due to COVID-19 pandemic during institutional childbirth in Nepal: before-and-after design by Ashish KC, Rejina Gurung, Prajwal Paudel, Honey Malla, Avinash K Sunny, Mats Målqvist, Omkar Basnet, Pratiksha Bhattarai

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Persistent effects of legal status on healthcare access and outcomes: findings from a state-wide representative cross-sectional survey in California by Lei Chen, Michelle Kao Nakphong, May Sudhinaraset, Nadereh Pourat, Maria-Elena De Trinidad Young

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A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses by Demosthenes Panagiotakos, Katherine Esposito, Paolo Chiodini, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano

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Correction: Making the most of existing research: an evidence gap map of the effects of food systems interventions in low-income and middle-income countries

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Cost-effectiveness and budget impact of Empirical vitamin D therapy on unintentional falls in older adults in the UK by J Smith, J S Davies, C D Poole

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