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  1. 981

    Early outcomes of treatment selections for infrarenal abdominal aortic aneurysms: The first five year experience of a single center by Bahadir Aytekin, Goktan Askin, Naim Boran Tumer, Hayrettin Levent Mavioglu, Seref Alp Kucuker, Ahmet Saritas, Hakki Zafer Iscan, Mehmet Ali Ozatik, Erol Sener

    Published 2024-03-01
    “…Results: A total of 332 patients received EVAR (Group 1), including 296 elective cases, while 90 patients underwent OSR (Group 2), with 66 being elective. Early mortality rates were significantly lower in the EVAR group (1.3% for elective and 27.8% for emergent) compared to the OSR group (6.1% for elective and 54.2% for ruptured cases, p=0.001). …”
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    Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

    Published 2025-02-01
    “…After overlapping with 3,490 DEGs and 550 MRGs in GSE5281, four genes were found to be causally related to AD, namely, G protein-coupled receptor, family C, group 5, member B (GPRC5B), Methyltransferase-like protein 7 A (METTL7A), NF-κB inhibitor alpha (NFKBIA) and RAS association domain family 4(RASSF4). …”
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    PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation. by Lujie Zhang, Yanni Gao, Haoran Zhou, Xiao Liang, Xiaolin Jiang, Wenqin Gong, Yangyang Sun, Desheng Zhang, Xianwei Wang, Hans Nauwynck, Juan Bai, Ping Jiang

    Published 2025-01-01
    “…Here, we screen that PRRSV-2 nsp2 activates the NLRP3 inflammasome, thereby instigating a state of hyperinflammation. …”
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  6. 986

    Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis by Wenpin Qin, Zhangyu Ma, Guo Bai, Wen Qin, Ling Li, Dongxiao Hao, Yuzhu Wang, Jianfei Yan, Xiaoxiao Han, Wen Niu, Lina Niu, Kai Jiao

    Published 2025-02-01
    “…The hydrogel is formed by cross-linking aldehyde-phenylboronic acid-modified sodium alginate/polyethyleneimine-grafted protocatechuic acid (OSAP/PPCA) and bevacizumab sustained-release nanoparticles (BGN@Be), termed OSPPB. The dynamic Schiff base bonds and boronic ester bonds allow for injectability, self-healing, and pH/reactive oxygen species dual responsiveness. …”
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    Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

    Published 2025-02-01
    “…Promoter CpG islands of a small number of genes, enriched in PRC2/histone methylation related gene-sets, gained methylation (△β-value > 0.4) in PDXs vs patient tumors. …”
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  14. 994

    Healthcare workers as a sentinel surveillance population in the early phase of the COVID-19 pandemic by Indumathi Venkatachalam, Edwin Philip Conceicao, May Kyawt Aung, Molly Kue Bien How, Liang En Wee, Jean Xiang Ying Sim, Ban Hock Tan, Moi Lin Ling

    Published 2022-10-01
    “…Methods: This was a retrospective cohort study conducted in Singapore General Hospital (SGH), a 1,822-bed tertiary hospital. Participants were all HCWs working in SGH during the study period. …”
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    Surgical treatment after neoadjuvant systemic therapy for HER2-positive invasive breast cancer in the Netherlands: 10-Year trends and the influence an accompanying DCIS component by Roxanne A.W. Ploumen, Thiemo J.A. van Nijnatten, Loes F.S. Kooreman, Adri C. Voogd, Kristien B.M.I. Keymeulen, Sabine Siesling, Marjolein L. Smidt

    Published 2025-02-01
    “…Patients with IBC+DCIS more often underwent mastectomy, with a rate of 48.4 % in 2019, compared to 30.0 % in IBC only (p < 0.001). Percentage of ypT0 was significantly lower in patients with IBC+DCIS (38.7 %), compared to IBC only (47.3 %, p < 0.001) Multivariable logistic regression analyses showed presence of DCIS (OR 1.69, 95%CI 1.47–1.95, p < 0.001) to be independently associated with mastectomy. …”
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