Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase by Jiaqian Wu, Marek R. Baranowski, Alexander E. Aleshin, Eta A. Isiorho, Lester J. Lambert, Laurent J. S. De Backer, Ye Na Han, Ranajit Das, Douglas J. Sheffler, Andrey A. Bobkov, Alexis M. Lemberikman, Daniel A. Keedy, Nicholas D. P. Cosford, Lutz Tautz

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High-performance CT features supporting accurate pre-operative tumor staging in colon cancer by Jianhua Yuan, Cangzheng Jin, Jianrong Si, Baobao Liu, Xiaohan Si, Jianzhi Chen

“…Multi-slice spiral computed tomography (CT) is currently the standard method for pre-operative clinical tumor staging, but accurately applying the CT findings in tumor staging remains a challenge due to the poor pathological understanding of the CT signs. We aimed to pathologically interpret the key CT findings in order to identify reliable markers for pre-treatment staging of colon cancer.Patients and methodsThe following CT features from 136 colon adenocarcinomas were analyzed: colon wall pliability, outline contour, pericolic fat attenuations and vascularity, tumor fusion with adjacent organs, ascites, tumor size, and relevance between tumor and retroperitoneal fascia. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Contamination by larvae of nematode was more frequent in fruit stores than in markets (35.9% vs. 19.7%; p=0.039). Areas with high and low economic values had the same frequency of contamination, but there was a trend to higher contamination by cestode eggs in areas with low economic values. …”
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Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

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High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil, Tel +55 34 3318 5326, Fax +55 34 3318 5342, Email rosekeila@terra.com.brBackground: The progression of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer is accompanied by a reduction in the immune response. …”
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Influence of tension cracks on moisture infiltration in loess slopes under high-intensity rainfall conditions by Xuancheng Ren, Weifeng Sun, Hengxing Lan, Han Bao, Langping Li, Shijie Liu, Changgen Yan, Xiaochan Wang, Zhouchen Li, Chaoyang Tian

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Peering into the Black Box: Forward Modeling of the Uncertainty Budget of High-resolution Spectroscopy of Exoplanet Atmospheres by Arjun B. Savel, Megan Bedell, Eliza M.-R. Kempton, Peter C. B. Smith, Jacob L. Bean, Lily L. Zhao, Kaze W. K. Wong, Jorge A. Sanchez, Michael R. Line

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Microenvironment modulation of TiO2 nanosheets for highly selective photocatalytic CO2 reduction by Xingxing Zheng, Jun Yang

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Prevalence of signs and symptoms of temporomandibular disorders (TMD) in a sample of medical students in Erbil city by Dilan Burhan Yousif, Zana Qadir Omer

“…Conclusion: In conclusion, the prevalence of temporomandibular disorder was high. The most common symptom reported by students were joint sounds and joint fatigue. …”
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Superior interface properties and unusual deformation mechanisms of high-entropy alloys through explosive welding by Yaping Zhou, Ze Hua, Lei Li, Yinxin Tan, Jiaohui Yan, Zhihui Lin, Wen Yang, Ke Jin, Ruiwen Shao, Tiansheng Liu

Subjects: “…Refractory high-entropy alloys…”
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Prenatal Cytogenetic Findings in 13.466 Cases of High-Risk Pregnant Women in One Laboratory by Leyla Özer, Evrim Ünsal, Özge Ayvaz, Aşkın Şen, Volkan Baltacı

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Spatial-temporal characteristics and influence factors of high-quality development of animal husbandry industry in China. by Tiantian Su, Cuixia Li

“…According to the defining characteristics of high-quality development in animal husbandry, this paper establishes a comprehensive evaluative indicator system. …”
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A highly active, low-cost CoZn ferrite electrocatalyst in oxygen reduction reactions by Qurat-Ul-Ain, Fawad Ahmad, Muhammad Irfan, Muhammad Imran Khan, Komal Ali Rao, Naseem Akhter, Abdallah Shanableh, Muhammad Babar Taj, Leonid G. Voskressensky, Rafael Luque

“…TGA shows high thermal stability of catalyst. Spinel structure remained unchanged even after electrochemical analysis as confirmed by FTIR. …”
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Regulatory mechanism of exogenous myo-inositol improving high temperature stress tolerance of tomato seedlings by CHEN Yan, HAN Liyuan, DU Zilong, ZHU Dongxing, ZHU Weimin, ZHANG Yingying

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The comparative characteristic of pheno- and genotypical signs in neonates with atresia of duodenum and other parts of the small intestine by O. K. Botvin'yev, A. V. Eremeeva

“…Analysis of phenotypical and genotypical signs in neonates with atresia of duodenum and other parts of the small intestine.Material and methods. …”
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Land cover classification of high-resolution remote sensing images based on improved spectral clustering. by Song Wu, Jian-Min Cao, Xin-Yu Zhao

“…The Lanczos algorithm, which determines the largest eigenpairs of a high-order matrix, was integrated with the spectral clustering algorithm to solve for eigenvalues and eigenvectors. …”
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Diabetic retinopathy further increases risk of cardiovascular disease mortality in a high-risk cohort by Richard Kha, Yasemin Kapucu, Mayuri Indrakumar, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Paul Mitchell, Gerald Liew

“…This study investigated if DR predicts risk of cardiovascular disease (CVD) mortality in a high CVD risk cohort. This was a prospective cohort study of 1582 adult participants who presented to a tertiary Australian hospital for evaluation of acute coronary syndrome by coronary angiography. …”
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LIFE CYCLE ASSESSMENT OF POINT-OF-LAY BIRDS TO FROZEN CHICKEN PRODUCTION IN A TROPICAL ENVIRONMENT by TEMITAYO A. EWEMOJE, OLUFEMI P. ABIMBOLA, OLAYINKA A. OMOTOSHO

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MXene-Assisted NiFe sulfides for high-performance anion exchange membrane seawater electrolysis by Jiaqi Wang, Yue Liu, Ganceng Yang, Yanqing Jiao, Youming Dong, Chungui Tian, Haijing Yan, Honggang Fu

“…Abstract Anion exchange membrane seawater electrolysis is vital for future large-scale green hydrogen production, however enduring a huge challenge that lacks high-stable oxygen evolution reaction electrocatalysts. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

“…Here, we describe a method that reproducibly generates thousands of organoids across multiple hiPSC lines. These High Quantity brain organoids (Hi-Q brain organoids) exhibit reproducible cytoarchitecture, cell diversity, and functionality, are free from ectopically active cellular stress pathways, and allow cryopreservation and re-culturing. …”
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