Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…Molecular docking simulation showed theoretical binding between SEN-GRP78 and SEN-IRE1α in three-dimensional structures. …”
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Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…Furthermore, the HLA-A cross-restriction for each epitope candidate was identified through peptide competitive binding assays using 12 transfected HMy2.CIR cell lines.ResultsA total of 45 epitopes demonstrated high affinity, while 31 epitopes displayed intermediate affinity. …”
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Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning by Xinye Zhu, Kin-Fai Ho, Tzu-Ting Yang, Vincent Laiman, Jian Sun, Zhenxing Shen, Hsiao-Chi Chuang

“…A549 cells were exposed to biomass PM2.5 at 0 and 50 µg mL–1 for 24 h, and the expression of Yes-associated protein (YAP), phosphorylated (p)-YAP, transcription coactivator with a PDZ-binding motif (TAZ), p-TAZ, E-cadherin, and high mobility group box 1 (HMGB1) proteins were assessed by Western blotting. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…Remimazolam has presented a favorable alternative to some of the common intravenous anesthetic agents used given its fast onset of action, high safety profile, and reasonably short duration of action. …”
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Erratum to ‘Cost differences between autologous and nonautologous cranioplasty implants: A propensity score–matched value driven outcomes analysis’ [World Neurosurgery: X (22C) (20... by Matthew Findlay, Sawyer Z. Bauer, Diwas Gautam, Matthew Holdaway, Robert B. Kim, Walid K. Salah, Spencer Twitchell, Sarah T. Menacho, Gurpreet S. Gandhoke, Ramesh Grandhi

“…Methods: The authors reviewed the hospital billing records over a 12-year period at their institution to identify patients who underwent cranioplasty after decompressive hemicraniectomy for trauma or stroke. …”
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD by Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

“…Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking are altered in APOE4 and AD models. …”
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Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription by Lipeng Pei, Yan Zhu, Wenpeng Li, Bin Xu, Jingli Sun

“…Moreover, Co-IP demonstrated that KAT2B bound to RBPJ, a transcriptional repressor, and increased the acetylation of RBPJ. RBPJ could bind to the MCM4 promoter to suppress the luciferase activity. …”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…In 40% of cases, a key mechanism of endocrine resistance to the standard first line is a mutation of the ligand-binding domain (LBD) of Estrogen Receptor 1 (ESR1) encoding estrogen receptor α (ER). …”
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Weighted EHR-based prevalence estimates for hypertension at the state and local levels in Louisiana by Wenjun Li, Meng Zhang, Jie Cheng, Sandra L. Jackson, Adam S. Vaughan, Michael Klompas, Thomas W. Carton, Elizabeth Nauman, Lee Mendoza, Arun Adhikari, Jeanie Donovan, Katherine H. Hohman

“…Although electronic health record (EHR) data have great potential for surveillance, population coverage is non-random, which may result in biased estimates. Statistical approaches are needed to adjust estimates to represent the underlying population and validate the results against independent estimates. …”
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Financial Innovations and Financial Inclusion Among Commercial Banks in Uganda: Case Study Of Kabale District. by Mpirirwe, Christine

“…Financial inclusion was substantially correlated with the creation of new products (rs = 0.605, p=0.003), the provision of high-quality products (rs = 0.248, p=0.005), product differentiation (rs = 0.985, p=0.000), and electronic bill payment (rs = 0.729, p=0.002). …”
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Influence of Mobile Money Crowding and Financial Service Delivery in Kabale Municipality: A Case Study of Mtn Uganda Kabale Branch. by Ahimbisibwe, Blair

“…These included that enables financial service and money transfers, mobile money enables customers to buy airtime from the service providers, mobile money transfer offers a wide range of transactions which have helped to reduce the crowing of customers in banks, the customer gets immediate feedback, mobile money provides a convenient way to send and receive money, pay bills, and make transactions. The study findings revealed the challenges faced by mobile money transfer services and this included security of financial transactions being executed from some remote locations, money transfer relies entirely on the strength of the network, compliance with diverse regulations can be complex and time-consuming, lack of interoperability between different mobile money platforms and financial institutions. …”
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An Update on African Trypanocide Pharmaceutics and Resistance. by Keneth Iceland, Kasozi, MacLeod, Ewan Thomas, Ntulume, Ibrahim, Welburn, Susan Christina

“…Resistance to suramin is associated with pathogen altered transport proteins. Melarsoprol binds irreversibly with pyruvate kinase protein sulfhydryl groups and neutralizes enzymes which interrupts the trypanosome ATP generation. …”
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Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. by Abhishek Bhatia, Alexander J Preiss, Xuya Xiao, M Daniel Brannock, G Caleb Alexander, Robert F Chew, Hannah Davis, Megan Fitzgerald, Elaine Hill, Elizabeth P Kelly, Hemalkumar B Mehta, Charisse Madlock-Brown, Kenneth J Wilkins, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily R Pfaff, N3C Consortium

“…Millions of treatment courses have been prescribed in the United States alone. Paxlovid was highly effective at preventing hospitalization and death in clinical trials. …”
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Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

“…Consolidated frontiers are areas with high and long term deforestation. Vulnerable frontiers have high forest cover but show signs of previous or recent deforestation and degradation. …”
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El desafío de construir una Psicología del desarrollo crítica en sociedades inhóspitas / The Challenge of Constructing a Critical Developmental Psychology in Inhospitable Societies... by Carlos Iván Orellana

“…Very well known analytical categories such as normative and non-normative developmental trends are subjected to scrutiny to show the relativity and biases of their usual applications. It is argued that, in the context of an inhospitable society, Developmental Psychology should consider at least: Early Childhood and Youth Adultisation Processes, the improbability of stable biographies, Precarious Old Age and the typical features of individuals living in the context of interest. …”
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Digitala läspraktiker i förskolan by Malin Nilsen

“…Slutsatserna betonar vikten av att strukturera digitala läsaktiviteter så att de inkluderar social interaktion och uppmuntrar barn att diskutera text och bild.  ENGLSIH ABSTRACT Digital Reading Practices in Preschool This study examines the use of the picture book service (Polyglutt) in Swedish preschools. …”
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The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression by Callan L. Attwell, Inés Maldonado-Lasunción, Ruben Eggers, Bastiaan A. Bijleveld, Ward M. Ellenbroek, Natascha Siersema, Lotte Razenberg, Dédé Lamme, Nitish D. Fagoe, Ronald E. van Kesteren, August B. Smit, Joost Verhaagen, Matthew R. J. Mason

“…Methods We first analysed binding site motifs in promoters of the RAG program to identify nine candidate growth-promoting TFs. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Results We found that NAT10 is highly expressed in CRC samples and plays a pro-oncogenic role. …”
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O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Abstract Background Lung ischemia–reperfusion (I/R) injury is a common clinical pathology associated with high mortality. The pathophysiology of lung I/R injury involves ferroptosis and elevated protein O-GlcNAcylation levels, while the effect of O-GlcNAcylation on lung I/R injury remains unclear. …”
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Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care by Eliza Kruger, Justin Nedzesky, Nina Thomas, Jeffrey D. Dunn, Andrew A. Grimm

“…International Classification of Diseases, Tenth Revision (ICD-10) diagnosis codes in any billing position for inpatient and outpatient claims (January 2016–February 2020) were identified for complications related to GSDIa. …”
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