A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…Here, we propose a covalent chimeric peptide-based targeted degradation platform (Pep-TACs) by introducing a long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking upon binding with the protein of interest. The Pep-TACs platform facilitates the degradation of target proteins through the mechanism of recycling transferrin receptor (TFRC)-mediated lysosomal targeted endocytosis. …”
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Retrievals of water vapour and temperature exploiting the far-infrared: application to aircraft observations in preparation for the FORUM mission by S. Panditharatne, S. Panditharatne, S. Panditharatne, H. Brindley, H. Brindley, C. Cox, R. Siddans, R. Siddans, J. Murray, J. Murray, L. Warwick, S. Fox

“…Comparable retrieval biases are observed for retrievals of temperature and water vapour; however, there is an increase of <span class="inline-formula">∼</span> 1 degree of freedom for water vapour and temperature for the FORUM configuration. …”
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Postcholecystectomy syndrome: the modern approach: resolution of Advisory council by V. T. Ivashkin, A. V. Okhlobystin, D. S. Bordin, E. Ya. Seleznyova, Yu. A. Kucheryavy, Ye. V. Bystrovskaya, O. C. Vasnev, M. F. Osipenko, G. H. Musayev, Yu. O. Shulpekova

“…Treatment has to include regular courses of selective antispasmodics, the presence of indications - prescription of bile acid supplements, when required - methods of endoscopic surgery.…”
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Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Adulhelm is an anti-amyloid drug that functions by selectively binding amyloid aggregates in both the oligomeric and fibrillar states. …”
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Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization by Fatma Beyazıt, Osman Balcı, Magdi Adam, Hasan İnal, Yeşim Bardakcı, Nafiye Yılmaz

“…A rapid, spectrophotometric Albumin Cobalt Binding (ACB) test was used to determine serum IMA levels and results were presented by absorbance units (ABSU). …”
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Climate change and the single cell by Derek T. A. Lamport

“…Finally, forests and the high albedo of snow-capped mountains and polar ice caps are essential to the Gaia hypothesis of James Lovelock and Lynn Margulis, which remains a brilliant metaphor despite earlier criticism.…”
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Video or audio listening tests for English language teaching context: which is more effective for classroom use? by Clara Herlina Karjo, Menik Winiharti, Safnil Arsyad

“…The participants were 100 students of the English Department, Bina Nusantara University (henceforth Binus) University Jakarta. …”
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Appartenenze ed esclusioni by Frederica Paletti

“…The investigation of the contents of these measures provides a vivid insight into the different forms that the concept of »citizenship«, understood as a link that binds the individual to the political community, received in those decades. …”
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Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis by Tanya S. McDonald, Cedric S. Cui, Titaya Lerskiatiphanich, Jianina Marallag, John D. Lee

“…Here, we investigated energy balance and glucose control in TAR DNA-binding protein 43 (TDP-43)Q331K mice, a model of ALS, at both the early and late symptomatic stages of disease. …”
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Los nuevos instrumentos para la operación de la política social en México (2018-2024) by Guillermo Miguel Cejudo Ramírez, Damián Ignacio Lugo Gutiérrez

“…Concluimos que estos instrumentos procedimentales operan de forma desarticulada, sin alcanzar las sinergias necesarias para la articulación efectiva de los programas sociales: no logran identificar apropiadamente a beneficiarios, caracterizar sus necesidades, acercar la oferta gubernamental a las personas, entregar los bienes o servicios ni monitorearlos. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…Machine learning models excel at identifying high-risk patients, predicting disease activity, and optimizing therapeutic strategies based on clinical, genomic, and immunological profiles. …”
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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…In addition, targeted experiments identified PVT1 as a key factor in the composition of PRC2-ERα network involved in downregulation of tumor suppressor genes, including BTG2.…”
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Preparation and Characterization of Rosa roxburghii Tratt Polyphenol-Sodium Alginate-Soy Protein Isolate Nanocomposites and Their Antioxidant Activity by Han LIU, Xiaoyan LIU, Yinping GUO, Xingyan MU, Zihui SHI

“…Compared with SPI and binary complexes, ternary complexes had significantly improved binding tightness, hydrophilicity, thermal stability and oxidation resistance. …”
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Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection by Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Rishun Li, Baobao Liu, Yuxin Wang, Li Yi, Shaohui Wang, Xiaogai Hou, Yang Wang

“…SAA and RH inhibit AI-2 synthesis through noncompetitive and competitive binding to S-ribosylhomocysteinase (LuxS). By inhibiting S. suis AI-2 quorum sensing, these compounds modulate the expression of adhesion genes and the synthesis of extracellular polysaccharides (EPS), reducing the adhesion ability of S. suis and ultimately inhibiting biofilm formation. …”
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CD47/SIRPα axis: bridging innate and adaptive immunity by Sjoerd H van der Burg, Anneloes van Duijn, Ferenc A Scheeren

“…The SIRPα receptor is expressed on myeloid cells and is an inhibitory immune receptor that, upon binding to CD47 protein, delivers a ‘don’t eat me’ signal. …”
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The Role of Endoscopy in the Treatment of Biliary Complications after Orthotopic Liver Transplantation by Alexey V. Kurenkov, Yury S. Teterin, Oleg D. Olisov, Petr A. Yartsev, Murad S. Novruzbekov, Kubay M. Magomedov

“…Aim: to improve the results of treating patients with anastomotic biliary strictures of the bile ducts after orthotopic liver transplantation.Materials and methods. …”
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Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein by Ziyuan Niu, Georgios Kementzidis, Miriam Rafailovich, Marcia Simon, Evangelos Papadopoulos, Bertal H. Aktas, Yuefan Deng

“…We found: 1) Structural deviations in the S-protein backbone at pH = 1 are 210% greater than those at pH = 7 at 75°C, with most of the deviations appearing in the receptor-binding domain (RBD). Smaller structural changes are observed at pH = 3 and 11. 2) The pH and thermal conditions impact on the protein structures: substantial acidic and basic conditions expand the protein’s solvent exposure, while high heat contracts. …”
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Transfer Across Episodes of Analogical Reasoning: The Role of Visuo-Spatial Schemas by Jairo A. Navarrete-Ulloa, Maximo Trench

“…The fact that these animations biased participants’ ratings in the same manner as in the previous experiments provides further evidence that dynamic visuo-spatial schemas can play a role in meta-analogical transfer.…”
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La experiencia de Costa Rica en el pago por servicios ambientales: 20 años de lecciones aprendidas by Oscar Sánchez-Chaves, Gílmar Navarrete-Chacón

“… Hace 20 años rompimos los esquemas tradicionales para  iniciar el reconocimiento de los bienes y servicios que los bosques le prestan a la sociedad costarricense y mundial, demostrando cómo los habitantes de un pequeño país centroamericano se propusieron revertir los procesos de pérdida de cobertura forestal, mediante un compromiso nacional de no depender de los recursos financieros externos para lograr un cambio de mentalidad en cuanto al desarrollo en armonía con la naturaleza y que incide de forma positiva en el paisaje rural. …”
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Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…Bevacizumab is a humanized anti-VEGF drug. By binding to VEGF, it loses the opportunity to activate VEGFR and then plays an anti-angiogenic role. …”
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