The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Abstract Gliomas represent a heterogeneous group of uniformly fatal brain tumors. Low and high-grade gliomas have diverse molecular signatures. …”
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Leucine-Rich Repeat Protein Family Regulates Stress Tolerance and Development in Plants by Hao Zhiqi, Wang Tingyi, Chen Dongdong, Shen Lan, Zhang Guangheng, Qian Qian, Zhu Li

“…LRR proteins can be divided into two categories: those containing LRR domains along with other structural elements, which are further subdivided into five groups, LRR receptor-like kinases, LRR receptor-like proteins, nucleotide-binding site LRR proteins, LRR-extensin proteins, and polygalacturonase-inhibiting proteins, and those containing only LRR domains. …”
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D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

“…Oncometabolites jeopardize genome stability and DNA repair by affecting high-order chromatin structure.…”
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Role of microRNA in the risk stratification of ischemic strokes by Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, May Adel Alhamid, Fawaz Al-Mufti

“…The study’s design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account.Results and findingsMicroRNA is an important biomarker for risk stratification in Ischemic Strokes. …”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

“…We find that CT-179 disrupts OLIG2 dimerization, phosphorylation and DNA binding and alters tumor cell-cycle kinetics, increasing differentiation and apoptosis. …”
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Modification of Recycled Industrial Solid Waste Incineration Fly Ash as a Low-cost Catalyst for NOx Removal by Darmansyah Darmansyah, Sheng-Jie You, Ya-Fen Wang

“…In summary, industrial solid waste incineration fly ash holds excellent potential when modified with metal oxides, serving as an economical and highly efficient catalyst for NOx removal.…”
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Pathogenesis of Functional Biliary Pain and Pharmacology of Trimebutin by E. L. Bueverova, O. Yu. Zolnikova, N. L. Dzhakhaya, A. V. Sedova, V. Т. Ivashkin

“…Currently, two main hypotheses are being considered to explain its cause: increased intraluminal pressure due to morphological and functional obstacles to bile outflow and visceral hypersensitivity. In the multilevel system of regulation of the gallbladder and sphincter apparatus, the opioid system occupies a special place. …”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…Contractility disorders along with increased lithogenicity followed by cyclooxygenase-2 overactivation in biliary tract tissue play significant pathogenic role; putative change in bile acid composition may be involved as well. Diagnosis of biliary dyskinesia requires first the careful analysis of pattern of pain and compliance of symptoms to biliary pain criteria; second, instrumental tests that exclude organic origin of biliary disease. …”
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Physiological analysis of cognitive load variations during complex information processing by Allan Armougum, Alexandre Gaston-Bellegarde, Chantal Joie-La Marle, Pascale Piolino

“…Though information processing is cognitively less demanding in experts, due to their high level of prior knowledge and considerable number of schemas, a rise in the information complexity in non-optimal context could generate an expertise reversal effect. …”
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The assembly factor Reh1 is released from the ribosome during its initial round of translation by Sharmishtha Musalgaonkar, James N. Yelland, Ruta Chitale, Shilpa Rao, Hakan Ozadam, David W. Taylor, Can Cenik, Arlen W. Johnson

“…In S. cerevisiae, the ribosome assembly factor Reh1 binds to pre-60S subunits at a late stage during their cytoplasmic maturation. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Despite advances in research and treatment, hepatobiliary diseases including carcinoma, viral hepatitis, fatty liver and bile duct defects have still been conundrums of the hepatobiliary field. …”
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The intestinal microbiome as a separate organ by Yu. O. Shulpekova

“…Interaction of bacteria with the «host» reminds cooperation of usual cells and can be carried out due to receptor binding, paracrine and humoral pathways, as well as due to phagocytosis and endocytosis. …”
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Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration by Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo

“…Results The results of molecular docking showed that the selected active compounds had good binding activity with the target. The binding energy between DHA and Aβ, Bcl-2, ATG5, LC3, Caspase3, LAMP1 is −5.7, −7.0, −5.8, −7.2, −6.9 kcal/mol. …”
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The Impact of Online Interactive Platform Services on Oral Health Behaviors in Older Adults With Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial by Yin Q, Chai Z, Tao B, Liu P, Luo Y, Zhao Q, Yang B

“…Qianyu Yin,1,2,* Zhaowu Chai,3,* Binbin Tao,1,2 Ping Liu,1,2 Yu Luo,1,2 Qinghua Zhao,4 Bing Yang1 1Department of Nursing, the Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2College of Nursing, Chongqing Medical University, Chongqing, People’s Republic of China; 3Outpatient Department at Longfor Guangnian, the Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 4Center of Nursing Research, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinghua Zhao, Center of Nursing Research, the First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86 18602308866, Email 201307@hospital.cqmu.edu.cn Bing Yang, Department of Nursing, the Affiliated Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, 401147, People’s Republic of China, Tel +86 13228649430, Email yangb@hospital.cqmu.edu.cnPurpose: Older adults with mild cognitive impairment (MCI) are at a high risk for oral health decline. …”
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The Heating Efficiency of Hot Jupiters from a Data-driven Perspective by Sheng Jin, Dong-Hong Wu, Yi-Xuan Cao, Zi-Yi Guo

“…Specifically, the increase in heating efficiency can be attributed to the increase in incident stellar flux, while the decrease in heating efficiency can be attributed to the rise in the gravitational binding energy associated with the increase in planetary mass.…”
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İŞYERİ HEKİMİNİN TÜRK İŞ HUKUKU’NDAKİ YERİ, GÖREV VE YÜKÜMLÜLÜKLERİ İLE SORUMLULUĞUNUN İNCELENMESİ by Ahmet Burak Beldüz

“…Hem sağlık hizmetinin sunulması hem de işyeri hekiminin risk değerlendirmesi çalışmalarına bizzat katılması, eğitim verme, bilgi verme ve diğer yükümlülükleri de iş sağlığının ve güvenliğinin sağlanması açısından işyeri hekiminin Türk iş hukukundaki yerinin ortaya konulmasında belirleyici rol oynamaktadır. …”
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Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy by Liqun Dai, Jie Liu, Tingyu Yang, Xiaorui Yu, Yi Lu, Lili Pan, Siming Zhou, Diyun Shu, Yuanhao Liu, Wuyu Mao, Zhiyong Qian

“…The vesicles demonstrate high efficiency in encapsulating doxorubicin, featuring a glutathione-responsive release mechanism, which present a promising option for tumor therapy. …”
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FathomDEM: an improved global terrain map using a hybrid vision transformer model by Peter Uhe, Chris Lucas, Laurence Hawker, Malcolm Brine, Hamish Wilkinson, Anthony Cooper, Alex A Saoulis, James Savage, Christopher Sampson

“…Existing global digital elevation models (DEMs) are widely used, however often suffer from systematic biases caused by trees, buildings and instrumentation error, ultimately limiting their effectiveness. …”
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Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Our analysis reveals extensive interactions between the HNH domain and adjacent subunits, including Cas6 and Cas11, with mutations in these key interactions significantly impairing enzymatic activity. Upon DNA binding, the Cas5-HNH/Cascade complex adopts a more compact conformation, with subunits converging toward the center of nuclease, leading to its activation. …”
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Racismo algorítmico: implicações na vivência de mulheres negras by Cyntia Barbosa Oliveira, Mariana Pinheiro de Souza

“…Para versar sobre o racismo que se dissimula no ambiente digital, autoras e autores como Patricia Hill Collins e Sirma Bilge, Kabengele Muanga, Safiya Umoja Noble, Tarcízio Silva e Sueli Carneiro, entro outros, são mobilizados. …”
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