Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…Molecular dynamics studies showed a high affinity and low binding energy for TTDB with HER2, ERK1, and SADPE with ER. …”
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QALYs: The Math Doesn’t Work by Tia G. Sawhney, Angela Dobes, Sirimon O'Charoen

“…The assessments are used in the development of recommendations for pricing, formulary placement decisions, and health policy decisions. A new bill, H.R. 485, the Protecting Health Care for All Patients Act of 2023, was approved by the US House Energy and Commerce Health Subcommittee that will, if passed, end the practice of using QALYs in all federal programs.^1,2^ Proponents of the ban say that QALYs undervalue the positive effects of therapeutics on people with disabilities.^3^ We share their concerns. …”
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Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment by Francesca Sardina, Federica Polverino, Sonia Valentini, Claudia Carsetti, Elisabetta Falvo, Giada Tisci, Silvia Soddu, Fabiola Moretti, Alessandro Paiardini, Cinzia Rinaldo

“…By biochemical and functional experiments, we demonstrate that MDM2 binds spastin and regulates its levels in a post-transcriptional manner independently of the E3 ubiquitin ligase activity. …”
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Two new nonrandomized response models for surveys on sensitive topics by Andreas Quatember

“… If the direct questioning in surveys on sensitive variables leads to non-ignorable nonresponse and untruthful answers, a considerably biased estimator might be the consequence. For such cases, the higher complexity of the indirect questioning designs such as the nonrandomized response models may pay off in terms of estimation accuracy assuming an increase in respondents’ cooperation. …”
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The distribution and spectrum of thalassemia variants in GUIYANG region, southern China by Xuanyin Zhao, Zhiyu You, Yunyan Deng, Yi Zhou, Dongyang Deng, Jian Quan, Fang Chen, Zhimei Yan, Ya Qi, Leilei Chen, Fang Xiang, Weixian Zheng, Ruyi Zhang

“…Geographical analysis revealed a concentration of cases in Guizhou Province, particularly in Guiyang city, Bijie, and Qiannan Prefecture. These findings provide valuable insights into the epidemiology of thalassemia in the region and the distribution of affected individuals.…”
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ROLLING REGRESSION CAPM ON ZAGREB STOCK EXCHANGE – CAN INVESTORS PROFIT FROM IT? by Tihana Škrinjarić

“…Weekly data on five sector indices from Zagreb Stock Exchange and the market index CROBEX with 91 day T-bill rates have been used for the period January 2012 – April 2018 in order to evaluate rolling regression CAPM on the Croatian market. …”
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An educational beit midrash as a bridge between religious and secular identity by Galia Semo, Doly Eliyahu-Levi

“…The research tool was an in-depth interview, conducted with 17 Bible teachers. Content analysis revealed three innovative realms of the educational beit midrash – pedagogical space, instruction, and learners. …”
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The role of esophageal and stomach motility disorders in pathogenesis of gastroesophageal reflux disease by Yu. V. Yevsyutina, A. S. Trukhmanov

“…In patients with GERD disorders of primary and secondary peristalsis of the esophagus, increase of frequency of transient lower esophageal sphincter relaxations and pathologic bile refluxes are common.Conclusion. Numerous studies are devoted to investigation of gastroesophageal reflux disease. …”
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THE EFFECT OF ENCAPSULATION ON SOME PROPERITES OF LACTOBACILLUS PLANTRAUM by P. K. Faraj, T. A. AL-Nashi

“…The study's findings showed that the use of olibanum gum in the first and second layers with alginate and chitosan protected the bacteria against various forms of pasteurization, as well as against extremely acidic conditions and high bile salt concentrations. After 28 days of storage at 4°C, the bacteria coated with the using of olibanum gum in the first and second layer demonstrated a great superiority in maintaining high numbers and better viability. …”
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ROLLING REGRESSION CAPM ON ZAGREB STOCK EXCHANGE – CAN INVESTORS PROFIT FROM IT? by Tihana Škrinjarić

“…Weekly data on five sector indices from Zagreb Stock Exchange and the market index CROBEX with 91 day T-bill rates have been used for the period January 2012 – April 2018 in order to evaluate rolling regression CAPM on the Croatian market. …”
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Proteomics integrated with metabolomics: Analysis of the internal mechanism underlying changes in meat quality in different muscles from bactrian camels by Rendalai Si, Liang Ming, Xueyan Yun, Jing He, Li Yi, Qin Na, Rimutu Ji, Tungalag Dong

“…These results offer effective information for producing high-quality camel meat.…”
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Twee weergawes van die gebed van Salomo (1 Kon. 8 en 2 Kron. 6): 'n vergelykende studie by D. F. O'Kennedy

“…We find this prayer in two different theological and literary traditions of the Bible: 1 Kings 8:22-53 and 2 Chronicles 6:12-42. …”
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Die sinodale verband van die Nederduitse Gereformeerde Kerk in die Vrystaat: enkele tendense by die ontstaan daarvan in 1864-1865 by P. J. Strauss

“… In the Reformed tradition the basic documents of a church, apart from the Bible on which it should be based, are its confessions of faith and its church order. …”
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The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative by Alice Kuaban, Alysha K. Croker, Jeffrey Keefer, Leonard A. Valentino, Barbara E. Bierer, Stephen Boateng, Donna DiMichele, Patrick Fogarty, C. Michael Gibson, Anna M. Hood, Lloryn Hubbard, Antonella Isgrò, Karin Knobe, Leslie Lake, Iman Martin, Michel Reid, Jonathan C. Roberts, Wendy Tomlinson, Lanre Tunji-Ajayi, Harriette G.C. Van Spall, Caroline Voltz-Girolt, Allison P. Wheeler, Alan E. Mast, Stephanie Seremetis

“…Eight issues identified include (1) harmonization of demographic terminology; (2) engagement of lived experience experts across the entire study timeline; (3) awareness of how implicit biases impede patient enrollment; (4) the need for institutional review boards to uphold the justice principle of clinical trial enrollment; (5) broadening of eligibility criteria; (6) decentralized trial design; (7) improving access to clinical trial information; and (8) increased community physician involvement. …”
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Christian Doctrines and the Death of Osinachi: Social Work Intervention with Women in Intimate Partner Violence in Nigeria. by Imafi, Kelly Alfred

“…The paper also established that the custodians of the Christian doctrines who are mainly men amplify the verses of the Bible that focus primarily on women to be submissive while they are silent about the areas that command men not to abuse their wives. …”
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Understanding Feminism Perspective on Informal Women Entrepreneurs in Kyengera Town Council by Henry Stanley, Mbowa, Siraje, Kaaya

“…This should include knowledge and science to constitute inclusion of women to eliminate male-biased ideologies.…”
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Gender and performance disparity in mathematics: A study of South Western Uganda by Amos, Musimenta, Francis Akena, Adyanga, Denis, Sekiwu

“…The study deconstructs the common gender-biased assumption that girls are naturally a ‘weaker sex’ and hence likely to embrace subjects that are considered ‘soft’ such as language, literacy, communication skills, social sciences among others. …”
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Verstedeliking: Riglyne vir 'n kerklike bediening by B. du T. Jackson

“…Churches should focus its ministry on the squatter communities. According to the Bible God in Christ never turned his back on the city, in spite of the concentration of sin within it, he is present with his children in the city. …”
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'Gelukkig hij die uw kinderen zal grijpen' by H. G. L. Peels

“…This imprecatory prayer, which still forms one of the most troublesome dimensions of Scripture for modern Bible-readers, is usually explained very negatively as a human but intolerable expression of personal or national rancour/hostility, and as such put in sharp contrast with the New Testament message of love for the enemy. …”
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Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…VSMCs incubated with the WLE for 1 hr showed no acute cytotoxicity. The binding of compounds 1–3 to PDE5 is slightly better than that of native PDE5 inhibitors. …”
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