Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction by Rüdiger Hardeland

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A novel flow cytometry-based quantitative monocyte adhesion assay to estimate endothelial cell activation in vitro by Vinnyfred Vincent, Himani Thakkar, Anjali Verma, Atanu Sen, Nikhil Chandran, Archna Singh

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Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Bra... by Al Tahan MA, Marwah MK, Dhaliwal M, Diaz Sanchez L, Shokr H, Kaur M, Ahmad S, Badhan RK, Dias IH, Sanchez-Aranguren L

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Novel insights into beta cell ER stress CHOP and its role in HFpEF development by Balaji Srinivas, Paula Fortuno, Hongmei Peng, Jiang Xu, Hamid Suhail, Hani N. Sabbah, Nour-Eddine Rhaleb, Khalid Matrougui

“…We aimed to determine the inter-relationship between C/EBP homologous protein (CHOP) in b-cells and HFpEF development. Methods Eight-week-old male mice b-cellflox/flox and b-cellCHOP−/− were randomly divided into four groups: control b-cellflox/flox and b-cellCHOP−/− mice subjected to standard diet and water. b -cellflox/flox and b-cellCHOP−/− mice fed a high-fat diet (HFD) and L-NAME (0.5 g/L) for five weeks. …”
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Clinical characteristics of patients with different subtypes of gestational diabetes mellitus: research results by N. I. Volkova, I. Y. Davidenko, Y. S. Degtiareva, Y. A. Sorokina, V. V. Avrutskaya

“…When GDM was detected, the Matsuda index was calculated: >50th percentile in comparison with the values of pregnant women without carbohydrate metabolism disorders, the patient belonged to the group of GDM with β-cell dysfunction; <50th percentile - to the GDM group with predominant insulin resistance.RESULTS AND DISCUSSION. …”
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Naphthenic Acid Fraction Components-Induced Metabolic and Mitochondrial Alterations in Rat Hepatoma Cells: Monitoring Metabolic Reprogramming with Tryptophan–Kynurenine Ratio by Laiba Jamshed, Amica Marie-Lucas, Genevieve A. Perono, Gregg T. Tomy, Jim J. Petrik, Richard A. Frank, L. Mark Hewitt, Philippe J. Thomas, Alison C. Holloway

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Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity by Su Y, Shui J, Qi D, Bai J, Xu X, Huang Y, Li R, Wu Q, Wang H, Cao C, Su Z, Zhang S

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Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice by S’Dravious A. DeVeaux, S’Dravious A. DeVeaux, Sofiya Vyshnya, Sofiya Vyshnya, Katherine Propsom, Oluwabukola T. Gbotosho, Asem S. Singh, Robert Z. Horning, Mihika Sharma, Anil G. Jegga, Liang Niu, Edward A. Botchwey, Edward A. Botchwey, Hyacinth I. Hyacinth

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Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats by Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B

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Association of a high rate of glycolysis and the activity of the uncoupling of oxidation and phosphorylation in the blood cells of patients with late-stage knee osteoarthritis and... by E. B. Chetina, G. A. Markova, K. E. Glemba, M. A. Makarov

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Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells by Bootsakorn Boonkaew, Nantawat Satthawiwat, Bianca C. Pachane, Lucy M. Brett, Pisit Tangkijvanich, Chaiyaboot Ariyachet

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Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries by Prashin Unadkat, Tania Rebeiz, Erum Ajmal, Vincent De Souza, Angela Xia, Julia Jinu, Keren Powell, Chunyan Li

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Current approaches for Usher syndrome disease models and developing therapies by Fiona K. Leith, Fiona K. Leith, Joey Lye, Joey Lye, Derek S. Delaney, Derek S. Delaney, Samuel McLenachan, Samuel McLenachan, Fred K. Chen, Fred K. Chen, Fred K. Chen, Fred K. Chen, Fred K. Chen, Marcus D. Atlas, Marcus D. Atlas, Elaine Y. M. Wong, Elaine Y. M. Wong, Elaine Y. M. Wong

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Enalapril therapy and thrombotic or inflammatory disturbances in essential arterial hypertension by O. M. Moiseeva, O. A. Berkovich, S. V. Villevalde, I. V. Emelyanov

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The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma by Walter M. T. Braga, Djordje Atanackovic, Gisele W. B. Colleoni

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Beyond thyroid dysfunction: the systemic impact of iodine excess by Aiman Khudair, Ahmed Khudair, Sara Anjum Niinuma, Haniya Habib, Alexandra E. Butler

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3-Hydroxyacyl CoA Dehydratase 2 Is Essential for Embryonic Development and Hepatic Metabolic Function Under a Low-Fat, High-Carbohydrate Diet by Lengyun Wei, Fengli Wang, Luoxue Hua, Qun Wang, Benfei Hu, Ziye Yang, Letao Li, Chenfeng Liu, Kezhen Wang

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Distinct types of protein modifications in diabetic endothelial dysfunction by Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen, Jiahai Shi, Guoliang Meng

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Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster by Wei Zhang, Rong Zhou, Xinjuan Lei, Mofei Wang, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Xinjie Li, Zhang Zutong, Liyang Wang, Odell D. Jones, Mengmeng Xu, Joseph Bryant, Jianjie Ma, Yingli Liu, Xuehong Xu

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Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders by Susmita Malwade, Carl M. Sellgren, Navneet A. Vasistha, Konstantin Khodosevich

“…Conclusions: Overall, we showed that although NDDs are only diagnosed during childhood or adolescence, the actual effect of genetic mutations on embryonic progenitor cells or early neurons may be strongest during fetal brain development, which could program the cascade for subsequent developmental changes and, together with further postnatal dysfunction, impair brain function.…”
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