Some of the Immunogenetics Aspects of Aging by Bushra N. Al Hadra

“…With advanced age, changes also occur in the B cell repertoire, which significantly affects the humoral immunity and leads to inadequate responses to infections and vaccines in the elderly. …”
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The development of postoperative pain in patients with late-stage knee osteoarthritis is associated with impaired metabolism and transport of fatty acids in blood cells by E. B. Chetina, G. A. Markova, K. E. Glemba, M. A. Makarov

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Factors promoting development of renal tubulointerstitial lesions in patients with diabetes mellitus by Minara Shamkhalovna Shamkhalova, Kseniya Olegovna Kurumova, Inna Igorevna Klefortova, Ivan Ivanovich Sitkin, Alexander Viktorovich Il'in, Margarita Ivanovna Arbuzova, Nikolay Petrovich Goncharov, Gul'nara Viktorovna Katsiya, Andrey Alexeevich Aleksandrov, Svetlana Semenovna Kukharenko, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov

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Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates by Pierre Gaudeaux, Pierre Gaudeaux, Juliette Paillet, Juliette Paillet, Monah Abou Alezz, Ranjita Devi Moirangthem, Ranjita Devi Moirangthem, Sara Cascione, Marta Martin Corredera, Marta Martin Corredera, Anne-Catherine Dolens, Anne-Catherine Dolens, Katrien De Mulder, Katrien De Mulder, Imke Velghe, Imke Velghe, Bart Vandekerckhove, Bart Vandekerckhove, Marieke Lavaert, Marieke Lavaert, Noémie Robil, Aurélien Corneau, Aurélien Corneau, Hanem Sadek, Pauline Rault, Akshay Joshi, Pierre de la Grange, Frank J. T. Staal, Frank J. T. Staal, Tom Taghon, Tom Taghon, Olivier Negre, Andrea Ditadi, Isabelle André, Tayebeh-Shabi Soheili

“…Despite these lineage predispositions, both subsets demonstrated plasticity, retaining the ability to differentiate into both T cells and natural killer (NK) cells in vitro. Additionally, in our experimental setting, we observed that BCL11B, a transcription factor essential for T cell commitment, regulates negatively myeloid cell differentiation while preserving the potential for NK cell development.ConclusionThese findings underscore the versatility of DLL4-based lymphoid progenitors in generating either T cells or ILCs in response to environmental cues. …”
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Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis by Philippe Bilodeau, Konstantinos Tselios

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Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis by Fabio Casciano, Paolo Severi, Laura Marongiu, Anna Caproni, Chiara Terranova, Alex Spitilli, Davide Ferrari, Chiara Ruzza, Peggy Marconi, Paola Rizzo, Paola Rizzo, Francesca Granucci, Paola Secchiero, Eva Reali

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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy by Ruifang Luo, Yuan Miao, Riqiang Hu, Fang Lin, Junyan Yan, Ting Yang, Lu Xiao, Zhujun Sun, Yuting Wang, Jie Chen

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HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia by Shu Zheng, Wei Feng, Zewen Sun, Peng Xu, Shuai Dong, Lin Pan, Huimin Shen, Jin He, Peng Chen, Chang Shu

“…Abstract Early-onset preeclampsia (EOPE) with fetal growth restriction (FGR) is a severe hypertensive disorder of pregnancy characterized by placental dysfunction and estrogen deficiency. Based on single-cell RNA sequencing (scRNA-seq) profiling of specific placental trophoblast subtypes from EOPE-FGR and normotensive pregnancies, we identified HSD17B1, which encodes a key enzyme mediating estradiol conversion, as the central dysregulated node in EOPE pathogenesis. …”
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Spatiotemporal regulation by downstream genes of Prok2 in the olfactory system: from development to function by Bo-Ra Kim, Min-Seok Rha, Min-Seok Rha, Hyung-Ju Cho, Hyung-Ju Cho, Joo-Heon Yoon, Joo-Heon Yoon, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim

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Early Cardiovascular Events in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation by Nazanin Aghel, MD, MSc, Vincent Wang, BHSc, Darryl Leong, MD, PhD, Michelle Lui, PharmD, MSc, Livia Fu, BNSc, MN, RN(EC), Jasmine Kang, MD, Dina Khalaf, MD, Irwin Walker, MD, Christopher Hillis, MD, MSc, Brian Leber, MD, Harry Klimis, MD, PhD, Anne Holbrook, MD, PharmD, MSc, Catherine Demers, MD, MSc, Philip Joseph, MD, MSc, Kylie Lepic, MD, Alejandro Garcia-Horton, MD, Tobias Berg, MD, PhD, Jeffrey Howard Lipton, MD, PhD, Mylinh Duong, MD, MSc, Jane Turner, MD, Jinhui Ma, PhD

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Targeted mitochondrial therapy for pancreatic cancer by Xinya Zhao, Guoyu Wu, Xufeng Tao, Deshi Dong, Jing Liu

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Therapeutic effects of adipose tissue-derived mesenchymal stem cells on ER stress in a murine model of metabolic dysfunction-associated steatohepatitis: an in vivo and in vitro stu... by Norihiko Ogawa, Akihiro Seki, Alessandro Nasti, Ho Yagi, Masatoshi Yamato, Hiiro Inui, Hiroki Nomura, Takuya Komura, Hidetoshi Nakagawa, Kouki Nio, Hajime Takatori, Tetsuro Shimakami, Masao Honda, Shuichi Kaneko, Yoshio Sakai, Taro Yamashita

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Evaluating the Causal Role of Genetically Inferred Immune Cells and Inflammatory Cytokines on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Lincheng Duan, Jingyi Yang, Junxin Zhao, Zhuoyang Chen, Hong Yang, Dingjun Cai

“…<b>Conclusions</b>: This study provides new insights into the causal role of immune system dysfunction in the development of ME/CFS, contributing to a deeper understanding of its underlying mechanisms. …”
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CD36 promotes iron accumulation and dysfunction in CD8 T cells via the p38-CEBPB-TfR1 axis in earlystage hepatocellular carcinoma by Yifei Qin, Fei Huo, Zhuan Feng, Jialu Hou, Yaxin Ding, Quancheng Wang, Yu Gui, Ziwei Yang, Jiali Yang, Gang Zhou, Ling Li, Jianli Jiang, Lingmin Kong, Shijie Wang, Gang Nan, Dingqiao Xu, Xiaohang Xie, Lijuan Wang, Qian He, Ruibin Yang, Peng Lin, Huijie Bian, Zhi-Nan Chen, Jiao Wu

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CLINIC-MORPHOLOGICAL ANALYSIS OF THE APPLICATION OF THE MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW CELLS IN ENDOMYOCARDIAL IMPLANTATION IN A PATIENT WITH SEVERE ISCHEMIC MYOCAR... by Ye. N. Kliever, A. M. Cherniavsky, Ye. A. Pokushalov, Ye. E. Kliever, А. М. Volkov

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Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm by Hyundong Yoon, Dohoon Lee, Seulki Song, Bonil Koo, Jihyun Park, Tae Kon Kim, Sun Kim, Sheehyun Kim, Junshik Hong, Ja Min Byun, Dong‐Yeop Shin, Inho Kim, Youngil Koh, Sung‐Soo Yoon

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Microvascular endothelial dysfunction in vascular senescence and disease by Daniel A. Kasal, Daniel A. Kasal, Viviane Sena, Grazielle Vilas Bôas Huguenin, Grazielle Vilas Bôas Huguenin, Andrea De Lorenzo, Eduardo Tibirica

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Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes by Xueqin Xie, Changchun Wu, Yuhe Yang, Wei Su, Fuying Dao, Jian Huang, Zheng Shi, Hao Lyu, Hao Lin

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Dimethyl-2-oxoglutarate but not antioxidants prevents glucose hypometabolism induced neural cell death: implications in the pathogenesis and therapy of Alzheimer's disease by Aman Chauhan, Karanpreet Bhutani, Aritri Bir, Ajay Singh, Sankha Shubhra Chakrabarti, Adesh K. Saini, Sasanka Chakrabarti, Arindam Ghosh

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Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases by Nikhil Raj Selvaraj, Durga Nandan, Bipin G. Nair, Vipin A. Nair, Parvathy Venugopal, Rajaguru Aradhya

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