Thrombocytopenia in Sepsis by Alireza Setarehaseman, Abbas Mohammadi, Robert W. Maitta

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Novel mutation SLFN14 T853fs associated with inherited macrothrombocytopenia by Haixiao Xie, Shiyi Tang, Jianmin Shao, Ming Yang, Huida Tong, Linhua Zhang, Mingzhu Zhong, Xiaomin Yu, Laixi Bi, Yuming Wang, Rongying Ou, Chen Ling, Liqing Zhu

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MicroRNA as a Potential Biomarker for Amyotrophic Lateral Sclerosis (ALS) by José Augusto Nogueira-Machado, Amanda Tábita da Silva Albanaz, Fabiana Rocha-Silva

“…<b>Background:</b> Amyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease that affects the muscles and results in paralysis. …”
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Acute Coronary Syndrome in Patients With 2 Type Diabetes Mellitus (Review of Literature; Description of the Clinical Case) by Bilous Z., Abrahamovych О., Mazur N., Ryabokon S., Ilenkiv N., Bevza N.

“…The process of glycosylation of proteins, especially apo-proteins of very low density and low density lipoproteins, arises as a result of the ability of glucose to non-enzymatically attach to them, which complicates the recognition of these modified lipoproteins by tissue B, E-receptors, causes inhibition of their elimination from the blood and enhanced capture by macrophages, followed by the formation of foam cells. …”
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The Hidden Dangers: E-Cigarettes, Heated Tobacco, and Their Impact on Oxidative Stress and Atherosclerosis—A Systematic Review and Narrative Synthesis of the Evidence by Arianna Magna, Nausica Polisena, Ludovica Polisena, Chiara Bagnato, Elena Pacella, Roberto Carnevale, Cristina Nocella, Lorenzo Loffredo

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Comprehensive Evaluation of Role of Metabolic Biomarkers in Atherosclerotic Plaque Microenvironment: The Enigma in Its Origin and Regression by Anshuman Pradhan, S. Siddharth Rao, A. Nyna Sindhu

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Comparison of light gradient boosting and logistic regression for interactomic hub genes in Porphyromonas gingivalis and Fusobacterium nucleatum-induced periodontitis with Alzheime... by Pradeep Kumar Yadalam, Shubhangini Chatterjee, Prabhu Manickam Natarajan, Carlos M. Ardila, Carlos M. Ardila

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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass

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Lipopolysaccharide and ARDS caused by new coronavirus infection: hypotheses and facts by I. A. Yatskov, V. A. Beloglazov, E. I. Ryapova

“…SP-A and SP-D, promoting early destruction of the cellular monolayers and lowering surface tension, interact with soluble CD14 receptor, which also has a pro-inflammatory effect on epithelial and endothelial cells, leading to p38MAPK activation via TLR4 receptors, causing degradation of IêBá protein and subsequent translocation of p65 NF-êB into the nucleus, thus inducing transcription of IL-6 and adhesion molecules (ICAM-1, VCAM-1 and E-selectin), and, as shown by Petruk et al. (2020), causing direct binding to the viral S protein in combination with LPS, thus enhancing activation of nuclear factor-kappa B (NF-êB) in monocytic THP-1 cells and cytokine responses in mononuclear blood cells. …”
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Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies by Axian Liu, Yutong Su, Jinwei Zhu, Yuan-Yuan Li

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Advances in immune mediated inner ear disease by Peter Kullar, Peter Santa Maria

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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

“…Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. …”
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Natural epigallocatechin-3-gallocarboxylate nanoformulation loaded doxorubicin to construct a novel and low cardiotoxicity chemotherapeutic drug for high-efficiency breast cancer t... by Ke Wang, Siqi Geng, Fang Wang, Baoru Fang, Huifeng Qian, Ying Li, Yiqing Zhou, Yanping Chen, Zhangsen Yu

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Chromatin modifiers in neurodevelopment by Sarallah Rezazadeh, Hong Ji, Cecilia Giulivi, Cecilia Giulivi

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2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity by Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Tae Woo Oh, Sang Il Gum, In-Jun Yang

“…Furthermore, 2′-FL lowered plasma tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels. In BV2 cells, it suppressed d-galactose-induced neuroinflammation by downregulating TNF-α and IL-6, and nuclear factor-κB signaling. …”
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Autophagy: An Overview of Molecular Mechanisms and Its Therapeutic Implications for Health and Disease by Hourolein Arab, Mohammad Reza Mofid, Mahboube Rahmati, Elahe Gharehkhani, Armin Mokhtariye, Mohammad Shokrzadeh

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Obstructive hypertrophic cardiomyopathy: from genetic insights to a multimodal therapeutic approach with mavacamten, aficamten, and beyond by Khadija Sarwer, Saeeda Lashari, Nida Rafaqat, Maher, Abdul Raheem, Muneeb Ur Rehman, Syed Muhammad Iraj Abbas

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Norcantharidin/Cu2+ dual-depleting GSH nanocatalyst with pH-responsive for CT/CDT synergistic cancer therapy by Xiaohuan Guo, Bingbing Cai, Qi Fang, Yanyan Chen, Yuzhu Zhou, Zhixing Liang, Changchun Wen, Yan-Cheng Liu, Hong Liang

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Mathematical modelling of the heterogeneity of disease progression and treatment outcomes in patients with COVID-19 by Guozhi Yu, Houhui Huang

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Gender-Dependent Modulation of Alzheimer’s Disease by Brain Ischemia. Comment on Lohkamp et al. Sex-Specific Adaptations in Alzheimer’s Disease and Ischemic Stroke: A Longitudinal... by Ryszard Pluta

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