PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication by Qiuyu Zhang, Qiuyu Zhang, Qiuyu Zhang, Feng Yue, Guopeng Sun, Liwei Jiang, Peng Li, Yanping Zhu, Zhike Liu, Zhike Liu, Yangzhao Zhu, Ruiyan Niu, Hua He, Zilong Sun, Xuannian Wang, Xuannian Wang

“…Programmed death-1 (PD-1) is a known immunoinhibitory receptor, and its expression causes immune dysfunction in B lymphocytes, resulting in increased progression of immunosuppressive diseases. …”
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An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China by Sabir Khan, Lin Cai, Hazrat Bilal, Muhammad Nadeem Khan, Wenjie Fang, Dongxing Zhang, Fen Yao, Xun Wang, Qian Wang, Bing Hou, Jiayue Wang, Chunyan Mao, Lingxi Liu, Yuebin Zeng

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Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis by Seiryo Ogata, Shingo Ito, Takeshi Masuda, Sumio Ohtsuki

“…This technique provides valuable insights into BBB dysfunction in central nervous system disorders and holds potential for improving brain-targeted drug delivery strategies.…”
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The epithelial era of asthma research: knowledge gaps and future direction for patient care by Christopher E. Brightling, Gianni Marone, Helena Aegerter, Pascal Chanez, Enrico Heffler, Ian D. Pavord, Klaus F. Rabe, Lena Uller, Del Dorscheid, the Epithelial Science Expert Group, Helena Aegerter, Arnaud Bourdin, Christopher E Brightling, Marco Caminati, Pascal Chanez, Del Dorscheid, Julia Eckl-Dorna, Ibon Eguiluz-Gracia, Enrico Heffler, Pieter Hiemstra, Gianni Marone, Oscar Palomares, Ian D. Pavord, Remo Poto, Klaus F. Rabe, Lena Uller, Gilda Varricchi

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Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment by Shurui Zhang, Jingwen Li, Xinyu Hu, Hanshu Liu, Qinwei Yu, Guiying Kuang, Long Liu, Danfang Yu, Zhicheng Lin, Nian Xiong

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Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment by Yusei Yamada, Mayuko Tanaka, Yusei Ikeda, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kotaro Matsusaka, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka

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Morphological features of changes in peripheral olfactory structures in SARS-COV-2 coronavirus infection by I. S. Shponka, V. I. Popovych, О. М. Usova, O. O. Bondarenko, Yu. V. Haman, H. Z. Shchuruk

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In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension. by Tobias G Schips, Karl W Kavalkovich, Lai-Ming Yung, Salam Ibrahim, Makhosi Edmondson, Zhigang Hong, Chin-Hu Huang, Simon Hinke, Xinkang Wang, Andrea R Nawrocki, Annmarie Winkis, Jinquan Luo, Iman Farasat, Brian Geist, Yang Wang, Russell Bialecki, Jey R Jeyaseelan, David R Bauman

“…We identified a mutant variant of human BMP9 that maintains its activity in endothelial cells, specifically preserving BMPR2 signaling while eliminating osteogenic signaling associated with ActR2A/B activation in mesenchymal precursor cells. …”
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The potential therapeutic role of melatonin in organ fibrosis: a comprehensive review by Wei Huang, Wei Huang, Juan Zheng, Ming Wang, Ming Wang, Ling-Yao Du, Ling-Yao Du, Lang Bai, Lang Bai, Hong Tang, Hong Tang

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Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson’s disease and cognitive decline pathophysiology by Frederick Clasen, Suleyman Yildirim, Muzaffer Arıkan, Fernando Garcia-Guevara, Lűtfű Hanoğlu, Nesrin H. Yılmaz, Aysu Şen, Handan Kaya Celik, Alagoz Aybala Neslihan, Tuǧçe Kahraman Demir, Zeynep Temel, Adil Mardinoglu, David L. Moyes, Mathias Uhlen, Saeed Shoaie

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Homozygous slc25a20 zebrafish mutant reveals insights into carnitine-acylcarnitine translocase deficiency pathogenesis by Ryuichi Hishida, Kohei Ishiguro, Tomoyuki Yamanaka, Shinya Toyokuni, Hideaki Matsui

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The interplay of factors in metabolic syndrome: understanding its roots and complexity by Md. Sharifull Islam, Ping Wei, Md Suzauddula, Ishatur Nime, Farahnaaz Feroz, Mrityunjoy Acharjee, Fan Pan

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Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial. by Gathsaurie Neelika Malavige, Chandima Jeewandara, Ananda Wijewickrama, Dumni Gunasinghe, Sameera D Mahapatuna, Chathurika Gangani, Vimalahan Vimalachandran, Geethal Jayarathna, Yashoda Perera, Chandanie Wanigatunga, Harsha Dissanayake, Shamini Prathapan, Eranga Narangoda, Damayanthi Idampitiya, Laksiri Gomes, Samurdhi Wickramanayake, Pramodth Sahabandu, Graham S Ogg

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Random forest-driven mortality prediction in critical IBD care: a dual-database model integrating comorbidity patterns and real-time physiometrics by Zhenze Zhang, Zhenze Zhang, Caiqing Zhao, Caiqing Zhao, Yijun Zhou, Ling Yao, Peng Liu, Ziling Fang, Nian Fang, Nian Fang

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Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis by Juexian Wei, Aijia Zhong, Yuting Zhang, Ehua Deng, Hengzong Mo, Hongyu Zhao, Jiayu Huang, Huaidong Peng, Kaiyin Zhang, Xiaohui Chen, Haifeng Mao, Yixin Chen, Yongcheng Zhu

“…<b>Background/Objectives</b>: This study aims to develop and evaluate neutrophil-membrane-coated nanoparticles (Siv@NMs) encapsulating sivelestat for the treatment of sepsis-induced endothelial injury. …”
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Management of Diabetic Ketoacidosis Complicated by Invasive Systemic Candidiasis in Type 1 Diabetic Patient: A Case Report by Ponvijaya M Yadav, Vineetha Naga Lakshmi Giduturi, Mahabir Prasad Mishra, Divam Prakash Singh, Vijayashree S Gokhale

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Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data by Li Guo, Shanshan Guo, Youlan Gong, Jing Li, Jiandong Li

“…Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. …”
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The Effects of Glucagon‐Like Peptide‐1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review by Victoria J. Old, Melanie J. Davies, Dimitris Papamargaritis, Pratik Choudhary, Emma L. Watson

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The role of gene polymorphisms in individually changing of the lipid profile among patients with coronary artery disease under the influence of the statin therapy by I. M. Fushtey, E. V. Sid, V. V. Litvinenko

“…In further studies of c.521C allele it was found a related increase of the statins concentration in human plasma, which leads to the progression of undesirable reactions such as myalgia, myopathy, and even rhabdomyolysis, asymptomatic increase transaminase activity and abdominal pain. The study of SLCO1B1 pharmacogenetics found that dysfunction of the protein-transporter leads to reduced absorption by the liver cells, the increasing of plasma concentrations and the change in the body's response to stationery. …”
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hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation by Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du

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