HISTOGENETIC ASPECTS OF PNEUMOFIBROSIS DURING CONIOTIC CHANGES IN KUZBASS MINERS by Олег Иванович Бондарев, Сергей Николаевич Филимонов

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In-depth analysis of the risk factors for persistent severe acute respiratory syndrome coronavirus 2 infection and construction of predictive models: an exploratory research study by Jia Zhang, Weihua Zhu, Piping Jiang, Feng Ma, Yulin Li, Yuwei Cao, Jiaxin Li, Zhe Zhang, Xin Zhang, Wailong Zou, Jichao Chen

“…Key predictors included comorbidities—hypertension, diabetes, and active malignancy—and immune dysfunction, marked by reduced B-cell and CD4 + T-cell counts. …”
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Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism by Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang

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Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes by Ameneh Mohammadi, Pedram Ebrahimnejad, Saeid Abediankenari, Zahra Kashi, Pooria Gill

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The chemotherapy agent doxorubicin induces CNS expression of Ascl1, a regulator of adult neurogenesis and differentiation by Christi Anne S. Ng, Morgan Pedus, Madeline F. Lee, Lawrence F. Kromer, Jeanne Mandelblatt, G. William Rebeck

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tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway by Zihao Deng, Yudi Li, Wenjun Chi, Wanzhou Zhang, Fangming Li, Li Ling

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Effects of Danggui Wuji granules on 16S rDNA, metagenome, and metabolome in BDS mice by Hanhui Huang, Yurong Deng, Shisheng Chen, Zongyuan Li, Xiaomin Li, Jianhui Sun, Liyu Hao, Zeyue Yu, Aoao Wang, Jianliang Li, Hairu Huo, Guimin Liu, Hongmei Li

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Anti-melanoma differentiation-associated gene 5 antibody associated rapidly progressive interstitial lung disease in a pediatric patient: a case report by Thitima Sirimontakan, Natalia Escobar, Fiona Kritzinger, Elizaveta Limenis, Greta Mastrangelo, Briseida Mema, Haifa Mtaweh

“…The infectious work up was negative for bacterial, fungal, and viral ethologies including Epstein–Barr virus; hepatitis A virus, hepatitis B, hepatitis C, and hepatitis E viruses; parvovirus B19; cytomegalovirus; herpes simplex virus 1 and 2; and human herpesvirus 6. …”
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MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance by Madhura Chatterjee, Sayoni Nag, Saurabh Gupta, Tanmoy Mukherjee, Prem Shankar, Deepak Parashar, Arindam Maitra, Kaushik Das

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MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters. by Inga Koneczny, Judith Cossins, Patrick Waters, David Beeson, Angela Vincent

“…In parallel, we investigated their ability to reduce AChR clusters in C2C12 myotubes induced by a) agrin, reflecting neuromuscular development, and b) by Dok7- overexpression, producing AChR clusters that more closely resemble the adult neuromuscular synapse. …”
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Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity by Xiang-mei Wen, Xiang-mei Wen, Xiang-mei Wen, Zi-jun Xu, Zi-jun Xu, Zi-jun Xu, Ji-chun Ma, Ji-chun Ma, Ji-chun Ma, Min-jie Zhang, Min-jie Zhang, Min-jie Zhang, Ye Jin, Ye Jin, Jiang Lin, Jiang Lin, Jiang Lin, Jun Qian, Jun Qian, Yuan-yuan Fang, Yuan-yuan Fang, Yuan-yuan Fang, Shu-yu Luo, Shu-yu Luo, Shu-yu Luo, Zhen-wei Mao

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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X 7 and P2Y 12 , the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. …”
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Mucus production and chronic obstructive pulmonary disease, a possible treatment target: zooming in on N-acetylcysteine by Federico Baraldi, Tommaso Bigoni, Maria Pia Foschino Barbaro, Claudio Micheletto, Giulia Scioscia, Alessandro Vatrella, Alberto Papi

“…It exerts a direct and indirect (glutathione replenishment) antioxidant mechanism; it interferes with inflammatory molecular pathways, including inhibition of nuclear factor-kB activation in epithelial airway cells and reduction in the expression of cytokine tumor necrosis factor α, interleukin (IL)-6, and IL-10. …”
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Primary Amyloidosis Presenting as Small Bowel Encapsulation by Jennifer Jones, Guido Van Rosendaal, Cynthia Cleary, Stefan Urbanski, Richard C Woodman

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Molecular architecture and catalytic mechanism of human glycogen debranching enzyme by Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan

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Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning by Hu Tang, Xiaorong Chen, Nengzhi Xia, Bin Wu, Guangju Zhao, Yahui Tang, Zhongqiu Lu

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Uremic toxins levels are associated with miR-223 in chronic kidney disease-associated anemia by Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, Ophélie Fourdinier, Benjamin Brigant, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad A. Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, Griet Glorieux, Laurent Metzinger

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Asymptomatic Leukocytospermia and Assisted Reproductive Technology Outcomes: Reason for concern? by Marie-Christin Reich, Natalie Heide, Peter Humaidan, Sandro C. Esteves

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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

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Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling. by Fengwen Xie, Bin Yuan, Ye Zhang, Liru Chen, Yingmei Zhong, Quan Xu

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