Targeting Sepsis: Disease Tolerance, Immune Resilience, and Compartmentalized Immunity by Alexis Garduno, Ignacio Martín-Loeches

“…Epigenetic mechanisms, including histone modification and trained immunity, present opportunities for reprogramming immune responses but require more precision to avoid unintended inflammatory sequelae. <b>Conclusions:</b> A deeper understanding of compartmentalized immune responses and the dynamic immune landscape in sepsis is critical for developing precision therapies. …”
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Puerarin, a key bioactive ingredient of Radix Puerariae, inhibits oxidative stress and protects against homocysteine-induced cardiac injury via PI3K/Akt/Nrf2/HO-1 signaling by Shuang Jiang, Cong Li, Yanxing Han, Jiandong Jiang, Yuhong Wang

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Post-viral olfactory loss and parosmia by Claire Hopkins, Abigail Walker, Paolo Boscolo-Rizzo, Zhen Yu Liu, Luigi Angelo Vaira

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New possibilities of thetherapy of patients with atopic dermatitis with Janus kinaseinhibitors by N. V. Zilberberg, M. M. Kokhan, Yu. V. Keniksfest

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Endothelial Alterations in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Potential Effect of Monocyte Interaction by Laura Atehortúa, Mauricio Rojas, Gloria M. Vásquez, Diana Castaño

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EXTREMELY HIGH-DOSE COLCHICINE INTOXICATION WITH NEUROLOGICAL COMPLICATIONS: A SURVIVAL CASE REPORT by Ömer Yıldırım, Fatih Albayrak, Orhan Zengin

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CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis by Zilin Liu, Yongqi Deng, Xiaomei Song, Xin Cai, Huaying Xiong, Liwen Tan, Shengsen Wei, Qiulin Li, Xiong Wang, Wei Jiang, Yaxi Chen, Qiu Li, Mo Wang

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Pediatric heart failure: Current approach and treatment by Benjamin A. Olsen, Shelley D. Miyamoto

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Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Wit... by Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y Abramov, Erik A Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R Duchen, David Latchman, Sarah J Tabrizi, Nicholas W Wood

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Prognostic and Immunological Significance of the Molecular Subtypes and Risk Signatures Based on Cuproptosis in Hepatocellular Carcinoma by Xiaolong Tang, Xiangqing Ren, Tian Huang, Yandong Miao, Wuhua Ha, Zheng Li, Lixia Yang, Denghai Mi

“…The signature also performed well in different stratification of clinical features. The immune cells, which included regulatory T cells (Treg), B cells, macrophages, mast cells, NK cells, and aDCs, as well as immune functions containing cytolytic activity, MHC class I, and type II IFN response, were remarkably distinct between the high-risk and low-risk groups. …”
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Research progress on the interaction between osteoarthritis and cardiovascular diseases by YANG Jianfeng, HAO Lin, WANG Yan, JI Quanbo

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SUDDEN SENSORINEURAL HEARING LOSS AND ITS ASSOCIATION WITH PATENT FORAMEN OVALE IN SCUBA DIVERS by Yaroslava V. Bondarenko, Yuliia V. Dieieva

“…The results of otoacoustic emission testing in the diver group exhibited significant deviations from the normal range in the low-frequency domain, with values notably lower than 6 dB. This suggests a potential impact of diving on the early changes in the function of outer hair cells. …”
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Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions by Hui Zhang, Keding Wang, Hairui Zhao, Bowen Qin, Xiaojing Cai, Manyi Wu, Junhua Li, Junhua Li, Jielian Wang

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Identification of m6 A-regulated ferroptosis biomarkers for prognosis in laryngeal cancer by Xin Wang, Wen Zhang, Kun Liang, Yujuan Wang, Jin Zhang, Jinping Wang, An Li, Yonggang Yun, Hiu Liu, Yanan Sun

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Uromodulin — Biological Significance and Prospects for Clinical Use by E. S. Levitskaya, M. M. Batiushin, M. Z. Gasanov

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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…The miRNAs that differentially expressed in tear samples of the POAG patients respect to the CG were the hsa miR-26b-5p (involved in cell proliferation and apoptosis), hsa miR-152-3p (regulator of cell proliferation, and extracellular matrix expression), hsa miR-30e-5p (regulator of autophagy and apoptosis), and hsa miR-151a-3p (regulator of myoblast proliferation).DiscussionWe are incredibly enthusiastic gathering as much information as possible on POAG biomarkers to learn how the above information can be used to better steer the diagnosis and therapy of glaucoma to prevent blindness in the predictable future. …”
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Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases by Suryakant Niture, Minghui Lin, Qi Qi, John T. Moore, Keith E. Levine, Reshan A. Fernando, Deepak Kumar

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Fueling neurodegeneration: metabolic insights into microglia functions by Mohammadamin Sadeghdoust, Aysika Das, Deepak Kumar Kaushik

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Construction of a novel lipid drop-mitochondria-associated genetic profile for predicting the survival and prognosis of lung adenocarcinoma by Ruijuan Cai, Hongsheng Lin, Qianwen Cheng, Qiyuan Mao, Chuchu Zhang, Ying Tan

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