Sepsis Course and Outcome Depends on the Genetic Variant in the 3`-Region of Aquaporin 4 Gene <i>AQP4</i> and Comorbidities by A. G. Chumachenko, E. K. Grigoriev, R. A. Cherpakov, I. N. Tyurin, V. M. Pisarev

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Photodynamic therapy for the precise treatment of localized prostate cancer by Youcheng Xu, Qinyuan Tan, Chong Sun, Yuefeng Jia, Shengxian Li, Xuecheng Yang

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Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes. by Cristina Martínez-García, Adriana Izquierdo-Lahuerta, Yurena Vivas, Ismael Velasco, Tet-Kin Yeo, Sheldon Chen, Gema Medina-Gomez

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Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study by Zehao Wang, Tianlun Yu, Yuqiao Liu, Yufan Wu, Jingqing Hu, Jingqing Hu

“…In the palmitoylation-related risk model, IGFBP2 was functionally validated through siRNA-mediated knockdown and a series of assays, including EdU incorporation, cell cycle analysis, wound healing, and transwell migration assays.ResultsTwo palmitoylation clusters (A/B) were identified, with Cluster B exhibiting poorer survival (P &lt; 0.001), enriched JAK-STAT signaling, and elevated immune infiltration (M1/M2 macrophages, CD8+ T cells). …”
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Efficacy of red algae and artichoke extracts in disrupting antioxidant/PI3K/RBP-4 pathway in high-fat diet-induced metabolic disorders in rats by Bashayer Khaled Alrashidi, Alshimaa A. Abd-Elmoneam, Ahmad Z. Ghareeb, Doaa A. Ghareeb

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Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut‐Ovary Axis by Yan Xiong, Xiaoxue Lu, Bohao Li, Shiyao Xu, Beibei Fu, Zhou Sha, Rong Tian, Rui Yao, Qian Li, Jingmin Yan, Dong Guo, Zixuan Cong, Yongliang Du, Xiaoyuan Lin, Haibo Wu

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The role of immune mechanisms in hypertension and advances in immunomodulatory research by XiaoLi Chen, Ling Sun, Ke Xuan, Aifen Zong

“…As hypertension progresses, many immune cells, such as macrophages, dendritic cells, NK cells, B and T lymphocytes, accumulate in organs such as the heart, blood vessels, and kidneys. …”
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Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection by Steven J. Mileto, Melanie L. Hutton, Sarah L. Walton, Antariksh Das, Lisa J. Ioannidis, Don Ketagoda, Kylie M. Quinn, Kate M. Denton, Diana S. Hansen, Dena Lyras

“…As the thymus has such a crucial role in T cell production and immune system development, these findings may have important implications in relapse of C. difficile disease and impaired immunity during C. difficile infection. …”
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Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis by Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo

“…Conclusions ANGPTL8 aggravates microglial pyroptosis via the PirB/NLRP3 pathway to accelerate the pathogenesis of AD. …”
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Peritoneal Dialysis -Associated Fibrosis: Emerging Mechanisms and Therapeutic Opportunities by Narayan Prasad, Saurabh Chaturvedi, Harshit Singh, Mary Priyanka Udumula, Atul Rawat, Meyyappan Jeyakumar, Akhilesh Jaiswal, Sachin Kumar, Vikas Agarwal

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Dual regulation of Atf3 and Lonp1 as therapeutic targets in cerebral ischaemia-reperfusion injury by Bo Yu, Lin Zhou, Min Zhou, Weijian Fan, Jindong Tong, Jinyun Tan, Weihao Shi

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The treatment of autoimmune hemolytic anemia with complement inhibitor iptacopan: a case report by Xiaoqing Li, Minran Zhou, Sai Ma, Ran Wang, Chuanli Zhao, Chunyan Chen

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Post-traumatic osteoarthritis: epidemiology, pathogenesis, clinical picture, approaches to pharmacotherapy by A. E. Karateev, A. A. Chernikova, M. A. Makarov

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Mini-review: Serum immunoglobulins and MASLD by Ke-qian Chen, Wen-jing Cao, Shu-zhi Wang, Wei Li

“…Serum immunoglobulin is a protein produced by the B cells after the body is stimulated by an external antigen or pathogen. …”
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Endocrine pathology in young rabbits with cystic fibrosis by Jie Xu, Kezhong Zhang, Xiubin Liang, Xia Hou, Y Eugene Chen, Jian-Ping Jin

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The hemostasis-regulating function and metabolism of liver in diabetes mellitus (literature review) by A.V. Yakushkina, A.V. Sergachev, D.G. Sardaeva, I.V. Kamalikhin, T.I. Vlasova

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21 by Eun Kyung Kim, Seung Hoon Lee, Joo Yeon Jhun, Jae Kyeong Byun, Jeong Hee Jeong, Seon-Young Lee, Jae Kyung Kim, Jong Young Choi, Mi-La Cho

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Cohort profile: pulmonary early assessment of the lung in paediatric cancer patients (SWISS-PEARL Study) by Christine Schneider, Gabriele Raffler, Maša Žarković, Christina Schindera, Jochen Rössler, Claudia E. Kuehni, Philipp Latzin, Alexander Moeller, Rahel Heule, Jakob Usemann, on behalf of the SWISS-PEARL study group

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A Comprehensive Review on Distribution, Pharmacological Properties, and Mechanisms of Action of Sesamin by Yao Zhang, Fen Liu, Yan Lin, Linhai Li, Mingfeng Chen, Lin Ni

“….), and to induce apoptosis and autophagy in cancer cells through a variety of signaling pathways such as NF-κB, JNK, p38 MAPK, PI3K/AKT, caspase-3, and p53. …”
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Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review by Chao-Nan Ma, Shan-Rui Shi, Xue-Ying Zhang, Guo-Song Xin, Xiang Zou, Wen-Lan Li, Shou-Dong Guo

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