Proinflammatory biomarkers and platelet aggregation activity in patients with coronary artery disease by O. A. Trubacheva, I. V. Kologrivova, O. L. Schnaider, I. V. Petrova, V. N. Vasiliev, I. V. Kovalev, I. Yu. Yakimovich

Get full text

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury by Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu, Yunsi Zheng

Get full text

Autophagy in inflammatory bowel disease: immunization, etiology, and therapeutic potential by Zhong-Xing Miao, Huan Meng, Jie Wang, Xiao-Ting Hou, Wen-Wen Cheng, Bao-Hong Liu, Qing-Gao Zhang, Qing-Gao Zhang, Shuo Yuan, Shuo Yuan

Get full text

Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations by Hamieh Goshtasbi, Nastaran Hashemzadeh, Marziyeh Fathi, Ali Movafeghi, Jaleh Barar, Yadollah Omidi

Get full text

Chronic Exposure to Field-Level Thiamethoxam Impairs Gut Tissue and Reduces Honeybee (<i>Apis cerana</i>) Survival by Yulong Guo, Changsheng Ma, Wenzheng Zhao, Haiou Kuang, Yakai Tian, Haoyuan Zhang, Yunfei Xue, Hongmei Li-Byarlay, Kun Dong, Xueyang Gong

Get full text

Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation by Masahiko Ito, Jie Liu, Masayoshi Fukasawa, Koji Tsutsumi, Yumi Kanegae, Mitsutoshi Setou, Michinori Kohara, Tetsuro Suzuki

“…The amount and size of lipid droplets were reduced in PLA2G4C-knockout cells. Inhibition of NF-κB or c-Myc activity suppressed lipid droplet formation in HCV-infected cells. …”
Get full text

Modern view on calcification of xenogenic bioprosthetic heart valves and their anti-calcification treatment strategies by A. E. Kostyunin, T. V. Glushkova, A. N. Stasev, E. A. Ovcharenko

Get full text

Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

Get full text

Mechanisms of hematogenous tumor metastasis. by V. I. Desyaterik, Y. S. Shevchenko

Get full text

Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease by Rasheed Sule, Po Hu, Clarissa Shoffler, Christopher Petucci, Benjamin J. Wilkins, Jack Rychik, Liming Pei

Get full text

Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks by Ivana Kawiková, Ivana Kawiková, Ivana Kawiková, Václav Špička, James C. K. Lai, James C. K. Lai, Philip W. Askenase, Li Wen, Zdeněk Kejík, Zdeněk Kejík, Milan Jakubek, Milan Jakubek, Karel Valeš, Karel Valeš, Filip Španiel, Filip Španiel

Get full text

Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid by Dongsheng Ji, Jiahui Zhang, Jihai Liang, Zhi-Shu Huang, Bing Shu, Ding Li

“…In the Aβ1-42-induced cell model, B14 could maintain mitochondrial function and number, regulate intracellular reactive oxygen species (ROS) and Ca2+ metabolism disorders, and effectively reduce Aβ1-42-induced apoptosis. …”
Get full text

Single Nucleotide Polymorphisms of IL-33 Gene Correlated with Renal Allograft Fibrosis in Kidney Transplant Recipients by Xuzhong Liu, Kun Liu, Zeping Gui, Dengyuan Feng, Zijie Wang, Ming Zheng, Shuang Fei, Hao Chen, Li Sun, Zhijian Han, Xiaobing Ju, Hengcheng Zhang, Ruoyun Tan, Min Gu

Get full text

Acute Heart Failure as a First Presentation of Pheochromocytoma Complicated with “Inverted” Takotsubo Syndrome by Jerrold Spapen, Jeroen de Filette, Stijn Lochy, Herbert Spapen

Get full text

Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

Get full text

Accelerated biological ageing as a complication of cancer therapy by O. O. Kovalov, M. Yu. Kolesnyk, O. V. Hancheva, I. F. Bielenichev, K. O. Kovalov

Get full text

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration by Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou

Get full text

CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…Therefore, we conclude that targeting CD40 directly on adipocytes, B-cells, T-cells, or CD40L on platelets is not a promising target to prevent hypertension complications.In summary, TRAF6 inhibition but not adipocyte, B-cell, or T-cell-specific CD40 or platelet-specific CD40L deficiency reduces pathophysiological vascular inflammation in hypertensive mice, suggesting TRAF6 inhibition as a potential therapeutic target in hypertensive patients.…”
Get full text

The Mechanisms of Chronic Inflammation in Obesity and Potential Therapeutic Strategies: A Narrative Review by Elvira Meni Maria Gkrinia, Andrej Belančić

“…Obesity, a global health concern of increasing significance, is characterized by chronic low-grade inflammation (LGCI) that significantly contributes to metabolic dysfunction. This narrative review explores the intricate pathophysiological mechanisms driving LGCI in obesity, emphasizing the role of adipose tissue, immune cell activation, and inflammatory signaling pathways. …”
Get full text

Hypokalemic Paralysis Secondary to Immune Checkpoint Inhibitor Therapy by Pragathi Balakrishna, Augusto Villegas

Get full text