Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases by Jie Gao, Lingling Wu, Siyang Wang, Xiangmei Chen

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Dynamic activity changes in transcription factors: Unlocking the mechanisms regulating physiological changes in the brain by Kentaro Abe

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Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma by Peng Luo, Zhenfa Zhang, Lianmin Zhang, Pengpeng Zhang, Mengzhe Zhang, Jianlan Liu, Zhaokai Zhou

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Immunosenescence: signaling pathways, diseases and therapeutic targets by Yichu Fu, Binhan Wang, Aqu Alu, Weiqi Hong, Hong Lei, Xuemei He, Huashan Shi, Ping Cheng, Xiangliang Yang

“…Abstract Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of proinflammatory cytokines in aged immune cells. …”
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Super‐Enhancer–Driven Syndecan‐4 Regulates Intercellular Communication in Hypoxic Pulmonary Hypertension by Xiaoying Wang, Xiangrui Zhu, Wei Huang, Zhaosi Wang, Jian Mei, Langlin Ou, Yunwei Chen, Cui Ma, Lixin Zhang

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Impacts of Early Weaning on Lamb Gut Health and Immune Function: Short-Term and Long-Term Effects by Chong Li, Yunfei Xu, Jiale Jia, Xiuxiu Weng, Yang Zhang, Jialin Peng, Xueming An, Guoxiu Wang

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Inter-Organelle Crosstalk in Oxidative Distress: A Unified TRPM2-NOX2 Mediated Vicious Cycle Involving Ca²⁺, Zn²⁺, and ROS Amplification by Esra Elhashmi Shitaw, Maali AlAhmad, Asipu Sivaprasadarao

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Regulation of synaptic function and lipid metabolism by Tongtong Zhang, Yunsi Yin, Xinyi Xia, Xinwei Que, Xueyu Liu, Guodong Zhao, Jiahao Chen, Qiuyue Chen, Zhiqing Xu, Yi Tang, Qi Qin

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Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy by Sonia Burgaz, Elisa Navarro, Santiago Rodríguez-Carreiro, Carmen Navarrete, Martin Garrido-Rodríguez, Isabel Lastres-Becker, Julia Chocarro, José L. Lanciego, Eduardo Muñoz, Javier Fernández-Ruiz

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Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia. by Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird

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Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer by Qinyuan Gong, Qinyuan Gong, Rongzhen Xu, Rongzhen Xu

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Mechanisms of immune regulation and transplantation immunity in corneal transplants by V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

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Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models by Mei Guo, Liming Liu, Xiao Mao, Manyu Xiao, Xiaobin He, Xing Pan, Yuewen Chen, Wanying Yi, Qibin Li, Xianglan Piao, Hua Wang, Yang Du, Yong Cheng

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Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders by Olayemi K. Ijomone, Ileje I. Ukwubile, Vivian O. Aneke, Tobiloba S. Olajide, Happiness O. Inyang, Omolabake I. Omotosho, Toheeb O. Oyerinde, Victor E. Anadu, Tolulope J. Gbayisomore, Oritoke M. Okeowo, David A. Oyeniran, Olumide A. T. Ogundahunsi, Omamuyovwi M. Ijomone

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The role of autoantibodies in bridging obesity, aging, and immunosenescence by Taylor R. Valentino, Nan Chen, Priya Makhijani, Saad Khan, Shawn Winer, Xavier S. Revelo, Daniel A. Winer

“…Obesity and aging share similar aspects of immune dysfunction, such as diminished humoral responses and heightened chronic inflammation, which can disrupt immune tolerance and foster autoantigen production, thus giving rise to autoreactive B cells and autoantibodies. …”
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Gut Microbiota and Vascular Diseases: An Update by Jiaqi Wu, Yuxuan Li, Peipei Yang, Jiantao Fu, Yidong Wang

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Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment by Shih-Jen Liu, Wan-Lun Yan, Chiao-Chieh Wu, Kuan-Yin Shen

“…Background The major challenge of antitumor immunotherapy is dealing with the immunosuppressive tumor microenvironment, which involves immature myeloid cell accumulation that results in T cell dysfunction. …”
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Machine learning approach to predict prognosis and immunotherapy responses in colorectal cancer patients by Zhen Liu, Dou Yu, Pengyan Xia, Shuo Wang

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Immunometabolic Interactions in Obesity: Implications for Therapeutic Strategies by Qin Fei, Jueru Huang, Yi He, Yufeng Zhang, Xiaojun Zhang, Jing Wang, Qiang Fu

“…We highlight the phenotypic shifts in key immune populations—macrophages polarized toward proinflammatory M1 phenotypes, T cell exhaustion occurrs, and alterations appear in B cells, natural killer (NK) cells, and dendritic cells—that collectively contribute to metabolic deterioration. …”
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Integrated evaluation of lung disease in single animals. by Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith

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