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    Circulating mitochondrial DNA signature in cardiometabolic patients by Alessandro Mengozzi, Silvia Armenia, Nicolò De Biase, Lavinia Del Punta, Federica Cappelli, Emiliano Duranti, Virginia Nannipieri, Rossana Remollino, Domenico Tricò, Agostino Virdis, Stefano Taddei, Nicola Riccardo Pugliese, Stefano Masi

    Published 2025-03-01
    “…Results We enrolled 120 consecutive patients: 50 (42%) with HF and preserved ejection fraction (HFpEF), 40 (33%) with HF and reduced ejection fraction (HFrEF) and 30 (25%) at risk of developing HF; 42/120 (35%) had diabetes. Cell-free mtDNA was increased in patients with HF (with higher levels in HFrEF than HFpEF) and those with diabetes. …”
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    Bridging the Gap Between hiPSC-CMs Cardiotoxicity Assessment and Clinical LVEF Decline Risk: A Case Study of 21 Tyrosine Kinase Inhibitors by Zhijie Wan, Chenyu Wang, Shizheng Luo, Jinwei Zhu, Hua He, Kun Hao

    Published 2025-03-01
    “…<b>Objectives</b>: There is growing concern over tyrosine kinase inhibitor (TKI)-induced cardiotoxicity, particularly regarding left ventricular dysfunction and heart failure in clinical treatment. …”
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    Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress by Yan Liu, Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li

    Published 2025-02-01
    “…The function of PDE4B was studied via gene intervention technology, and the results showed that PDE4B can aggravate hepatic IRI. …”
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