TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism by Surendran Parvathy, Budhaditya Basu, Suresh Surya, Rahul Jose, Vadakkath Meera, Paul Ann Riya, Nair Pradeep Jyothi, Rajendran Sanalkumar, Viviane Praz, Nicolò Riggi, Biju Surendran Nair, Kamalesh K. Gulia, Mukesh Kumar, Balachandran Krishnamma Binukumar, Jackson James

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Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes by Mona Rady, Albert Ashraf, Hesham Abdelaziz, Mohamed El-Azizi

“…Our findings provide insights into the adaptive immune dysfunction in CRC, offering a detailed profile of gene expression changes associated with T and B cell activation and antibody production. …”
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An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics by Shaobo Wang, Qiong Zhang, Hui Hui, Kriti Agrawal, Maile Ann Young Karris, Tariq M. Rana

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Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation by Asmaa M. Gaber, Adel Abdel-Moneim, Eman S. Abdel-Reheim, Gamal Allam, Manal Abdul-Hamid, Ahmed Hosni, Ahmed Hosni

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Fungal colonization before or after lung transplantation has no negative impact on survival or the development of chronic lung allograft dysfunction by Embla Bodén, Fanny Sveréus, Anna Niroomand, Hamid Akbarshahi, Richard Ingemansson, Hillevi Larsson, Sandra Lindstedt, Franziska Olm

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Prevention of Postischemic Neurological Deficit by Modulating the Cerebral Cell Expression of ADP-Ribosyl Cyclase (Experimental Study) by A. A. Fursov, A. B. Salmina, S. V. Mikhutkina, L. D. Zykova, N. A., Malinovskaya, A. V. Morgun, D. I. Laletin, M. A. Fursov, G. V. Yudin, N. A. Shnayder, S. V. Shakhmaeva

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Sulforaphane from Brassica Oleracea Induces Apoptosis in Oral Squamous Carcinoma Cells via p53 Activation and Mitochondrial Membrane Potential Dysfunction by Pooja Narain Adtani, Sura Ali Ahmed Fuoad Al-Bayati, Walid Shaaban Elsayed

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Pathophysiological role of endothelial biomarkers in Bothrops sp. venom-induced renal dysfunction and the therapeutic effect of antivenom by Nicole Coelho Lopes, Gdayllon Cavalcante Meneses, Ranieri Sales de Souza Santos, Leticia Machado de Araújo, Bruna Viana Barroso Martins, Katarina Maria dos Reis Araújo, Valéria Holanda Nogueira de Aquino, Igor Moreira de Almeida, Sandra Mara Brasileiro Mota, Geraldo Bezerra da Silva Junior, Camila Eleuterio Rodrigues, Elizabeth De Francesco Daher, Polianna Lemos Moura Moreira Albuquerque, Alice Maria Costa Martins

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Hyperhomocysteinemia as a risk factor for the development of pathological changes in the cardiovascular system: Mechanisms and consequences by Todorović Dušan, Đurić Dragan, Stojanović Marija

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Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis by Jie Chen, Shinuan Fei, Lawrence W.C. Chan, Xueting Gan, Bibo Shao, Hong Jiang, Sheng Li, Peng Kuang, Xin Liu, Sijun Yang

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Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction by Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan

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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

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Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming by Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao

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OCCURRENCE OF SEQUENTIAL MULTIPLE MYELOMA FOLLOWING B-CELL NON-HODGKIN LYMPHOMA: A CASE REPORT by DPM Almeida, ES Costa, S Romano, MGP Land

“…Aim: To report a case of untreated B-cell NHL subsequently diagnosed with MM. Case presentation: A 68-year-old woman with a cardiac left bundle branch block was diagnosed with indolent B-cell NHL based on peripheral blood (PB). …”
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Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation by Yuchen Cai, Tianyi Zhou, Xueyao Cai, Wenjun Shi, Hao Sun, Yao Fu

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Characteristics of B-lymphocyte subpopulations in renal transplant recipients by S. V. Zybleva, S. L. Zyblev

“…We have found that on the 3rd post-transplant day, the relative level of non-switched memory B lymphocytes (CD19+IgD+CD27+) exceeding or equal to 11.47%, and the level of switched memory B lymphocytes (CD19+IgD-CD27+) exceeding or equal to 20.74% might predict the development of early renal graft dysfunction with a sensitivity and specificity of 88.40% and 84.30% for the former parameter and of 88.70% and 82.40% for the latter one, respectively.…”
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Development of a PPP1R14B-associated immune prognostic model for hepatocellular carcinoma by Ligang Zhao, Xiaoling Jin, Qiushi Yu, Yigang He, Facai Yang, Weihu Ma, Zhengqing Lei, Jiahua Zhou

“…PPP1R14B levels exhibited notable associations with various immune cells, including memory B lymphocytes, M1/M2 macrophage populations, CD8-positive T lymphocytes, and T follicular helper cells. …”
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Mitochondria of transformed cell as a target of antitumor influence by E. M. Frantsiyants, I. V. Neskubina, E. A. Sheiko

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Prenatal Bisphenol B Exposure Induces Adult Male Offspring Reproductive Dysfunction via ERα Inhibition-Triggered MHC I-Mediated Testicular Immunological Responses by Nannan Chen, Xiaotian Li, Shenrui Zhou, Xin Peng, Senlin Xue, Yuetong Liu, Tingwang Jiang, Wei Yan

“…As an emerging endocrine-disrupting agent and structural analog of bisphenol A (BPA), bisphenol B (BPB) raises significant concerns due to its potential to induce male reproductive toxicity. …”
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Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells by Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci

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