Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver by Monika Gjorgjieva, Nicolas Calo, Cyril Sobolewski, Dorothea Portius, Jean-Luc Pitetti, Flavien Berthou, Anne-Sophie Ay, Marion Peyrou, Lucie Bourgoin, Christine Maeder, Margot Fournier, Marta Correia de Sousa, Etienne Delangre, Laurent Vinet, Xavier Montet, Christine Sempoux, Serge Nef, Michelangelo Foti

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Elucidation of Artemisinin as a Potent GSK3β Inhibitor for Neurodegenerative Disorders via Machine Learning-Driven QSAR and Virtual Screening of Natural Compounds by Hassan H. Alhassan, Malvi Surti, Mohd Adnan, Mitesh Patel

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Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature by Thejus Jayakrishnan, Amir Kamran, Deep Shah, Aritra Guha, Muhammad Salman Faisal, Prerna Mewawalla

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Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH by Thomas Zöggeler, Anna Maria Kavallar, Adam Robert Pollio, Denise Aldrian, Cornelia Decristoforo, Sabine Scholl-Bürgi, Thomas Müller, Georg Friedrich Vogel

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Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia by Soo Yeon Jang, Kyung Mook Choi

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Molecular mechanisms of oogenesis by V. G. Zenkina, O. A. Solodkova, G. G. Bozhko, A. A. Agibalova, I. S. Zenkin

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Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population by Xiaojuan Wu, Ying Wang, Yumei Jia, Jia Liu, Guang Wang

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Feasibility and Safety of Ex Vivo Delivery of Rituximab to Lung Allografts in Transplant Recipients at High Risk for Epstein-Barr Virus–associated Posttransplant Lymphoproliferativ... by Victor H. Ferreira, PhD, Rafaela V. P. Ribeiro, MD, PhD, Faranak Mavandadnejad, PhD, Matthew Ierullo, MSc, Beata Majchrzak-Kita, MSc, Aizhou Wang, PhD, Lianne Singer, MD, Shaf Keshavjee, MD, Marcelo Cypel, MD, PhD, Deepali Kumar, MD, Atul Humar, MD

“…One patient experienced primary graft dysfunction. Peripheral B-cell counts were reduced immediately posttransplant and remained low in some patients, whereas others rebounded over the weeks posttransplant, and serum rituximab levels were undetectable after 2 wk. …”
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Palmitoleate protects against lipopolysaccharide-induced inflammation and inflammasome activity by Prakash Kumar Sahoo, Aiswariya Ravi, Baolong Liu, Jiujiu Yu, Sathish Kumar Natarajan

“…However, prolonged inflammation could perturb cell homeostasis and contribute to the development of metabolic and inflammatory diseases, including maternal obesity, diabetes, cardiovascular diseases, and metabolic dysfunction–associated steatotic liver diseases (MASLD). …”
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In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors by Alexander T. Mikhailov, Mario Torrado

“…We discuss the involvement of MYOCD, MRTF-A, and MRTF-B in the development of cardiac dysfunction and to what extent modulation of the expression of these factors in vivo can correlate with cardiac disease outcomes. …”
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Prepubertal Exposure to Tris(2-chloroethyl) Phosphate Disrupts Blood-Testis Barrier Integrity via Ferritinophagy-Mediated Ferroptosis by Yonggang Zhao, Mo Peng, Honglei Liu, Xiaoyu Zhang, Dan Fu

“…TCEP exposure resulted in the disruption of blood-testis barrier (BTB) integrity and in abnormal testicular development. Considering that Sertoli cells constitute the primary target of toxicants and that TCEP induces oxidative stress in the testis and other organs, we focused on ferroptosis in Sertoli cells. …”
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Microglia target synaptic sites early during excitatory circuit disassembly in neurodegeneration by Alfred Yu, Camille Fang, Li Xuan Tan, Aparna Lakkaraju, Luca Della Santina, Yvonne Ou

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AGE- MACULAR DEGENERATION AND GLAUCOMA. EPIDEMIOLOGICAL AND CLINIC-PATHOGENETIC ASPECTS by A. Z. Fursova, O. G. Gusarevich, M. S. Tarasov, M. A. Vasilyeva, N. V. Chubar, N. V. Litvinova

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Research progress on AMPK in the pathogenesis and treatment of MASLD by Jiang Feng, Li MengHuan, Yao TingTing, Yi XueJie, Gao HaiNing

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Atorvastatin for prevention of disease progression and hospitalisation in liver cirrhosis: protocol for a randomised, double-blind, placebo-controlled trial by Torben Hansen, Nina Kimer, Henning Grønbæk, Rikard Gøran Fred, Atul Shahaji Deshmukh, Mathias Mann, Flemming Bendtsen

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Integrative analysis of mitochondrial-related gene profiling identifies prognostic clusters and drug resistance mechanisms in low-grade glioma by Xiaozan Chang, Yingxuan Huang, Ying Qu, Yu Guo, Wenwen Fan, Haining Zhen

“…Mutation landscape analysis revealed distinct genetic alterations and copy number variations among clusters, particularly in Cluster B, which exhibited unique genetic signatures. Immune infiltration analysis showed that Cluster B had higher expression levels of immune checkpoint genes, stronger immune evasion activity, and greater immune cell infiltration, suggesting an immunosuppressive tumor microenvironment. …”
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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis by Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, Pan Liao, Bo Yan, Wei Zhang, Fang-Yuan Cheng, Ya-Ru Liu, Zi-Han Zhang, Cheng Wei, Jie Zhou, Fang-Lian Chen, Ping Lei, Xin-Tong Ge

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Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury by Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel

“…No differences were seen for astrocytes, microglia, macrophages, B-cells, and neutrophil infiltration between males and females. …”
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COVID-19 and chronic obstructive pulmonary disease: what is known about the unknown by E. S. Ovsyannikov, S. N. Avdeev, A. V. Budnevskiy, E. S. Drobysheva, A. Ya. Kravchenko

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RESTORATION OF CORNEA ENDOTHELIUM FUNCTION (REVIEW) by G. S. Baturina, L. E. Katkova, E. I. Solenov, I. A. Iskakov

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