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  1. 781

    Cellular Senescence in Health, Disease, and Lens Aging by Ying Qin, Haoxin Liu, Hongli Wu

    Published 2025-02-01
    “…<b>Background</b>: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease. …”
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    Chronic ethanol administration exacerbates memory loss by altering N6-methyladenosine-mediated epigenetic signaling by Yuanhang Liao, Fu Xu, Yuqing Yan, Sicheng Zhou, Sicheng Zhou, Na Liu, Baomin Dou, Nivetha Srinivasan, Weizheng Wang, Xiongwei Zhu, Jianghong Ye, Ying Xu

    Published 2025-07-01
    “…These results were further supported by molecular biological and mRNA-microRNA-lncRNA ceRNA network analyses that demonstrated that the increased Rbm15b and decreased Hnrnpa2b1 were involved in synaptic dysfunction and neuroinflammation in CIE-induced memory impairment in these AD mice.ConclusionsThe conclusion is drawn that m6A mediated epigenetic dysfunction and immune cells infiltration participate in chronic alcohol use disorder related memory loss in AD mice.…”
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  8. 788

    Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway by Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li, Tao Wang

    Published 2025-05-01
    “…In addition, numerous studies have reported that eIF3a over expression plays an important role in the occurrence and development of fibrotic diseases, cancer, and degenerative lesions, however, the mechanisms of eIF3a affecting the dysfunction of pulmonary arterial endothelial cells remains largely unknown. …”
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