The potential of efferocytosis for the treatment of bronchial asthma: A review of current trends, mechanisms and prospects by Baohe Liu, Tingting Zu, Yaqi Lu, Chaopin Xing, Meng Gao, Fuling Wu, Mengqi Jiang

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BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain by Mingming Xie, Dan Li, Haohao Zeng, Yulin Huang, Rui Xu, Zhen Wang, Jiacheng Yu, Yu’e Sun, Yu’e Sun

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The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells by Peng Jiao, Weiming Li, Lin Shen, Yan Li, Lili Yu, Zhaohui Liu

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Umbilical Cord-Derived Mesenchymal Stem Cells Infusion in Type 2 Diabetes Mellitus Patients: A Retrospective Cytopeutics’ Registry Study by Chin SP, Kee LT, Mohd MA, Then KY

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Epicardial Adipose Tissue and Heterogeneity Parameters Combined with Inflammatory Cells to Predict the Value of Heart Failure with Preserved Ejection Fraction Patients Post Myocard... by Yu-jiao Song, Xiao-ying Zhao, Lu-jing Wang, Ting Ning, Ming-tian Chen, Pei Liu, Si-wen Chen, Xin-xiang Zhao

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Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis by Jia Li, Xiao-Yu Cheng, Rui-Xia Ma, Bin Zou, Yue Zhang, Miao-Miao Wu, Yao Yao, Juan Li

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Decompensated MASH-Cirrhosis Model by Acute and Toxic Effects of Phenobarbital by Nico Kraus, Frank Erhard Uschner, Magnus Moeslein, Robert Schierwagen, Wenyi Gu, Maximilian Joseph Brol, Eike Fürst, Inga Grünewald, Sophie Lotersztajn, Pierre-Emmanuel Rautou, Marta Duran-Güell, Roger Flores Costa, Joan Clària, Jonel Trebicka, Sabine Klein

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Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs by Teppei Kouga, Toru Miwa, Toru Miwa, Fan-yan Wei, Kishiko Sunami, Kazuhito Tomizawa

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Leveraging radiotherapy to improve immunotherapy outcomes: rationale, progress and research priorities by Faith Hartley, Martin Ebert, Alistair M Cook

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Non allergic gastrointestinal manifestations of hereditary alpha-tryptasemia by Dylan Vainer, Kathryn Peterson

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EXPERIMENTAL PARTICIPATION OF PHARMACOLOGICAL SUBSTANCES IN MECHANISMS OF LEAD ACETATE TOXICITY by S. G. Dzugkoev, F. S. Dzugkoeva, O. I. Margieva, A. E. Khubulova, I. V. Mozhaeva

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Limosilactobacillus reuteri DS0384 promotes intestinal epithelial maturation via the postbiotic effect in human intestinal organoids and infant mice by Hana Lee, Kwang Bo Jung, Ohman Kwon, Ye Seul Son, Eunho Choi, Won Dong Yu, Naeun Son, Jun Hyoung Jeon, Hana Jo, Haneol Yang, Yeong Rak Son, Chan-Seok Yun, Hyun-Soo Cho, Sang Kyu Kim, Dae-Soo Kim, Doo-Sang Park, Mi-Young Son

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IMMUNOREGULATORY IMBALANCE AND FUNCTIONAL STATE OF THE HEART IN THE PATIENTS WITH DIABETES MELLITUS TYPE 2 by I. V. Kologrivova, T. E. Suslova, I. V. Vinnitskaya, O. A. Koshelskaya, A. A. Boshchenko, O. A. Trubacheva

“…The numbers of FoxP3+T egulatory lymphocytes, Treg/Th17 lymphocyte ratio, and mean fluorescence intensity of IL-17 for Th17 cells was lower in patients with diabetes mellitus and diastolic dysfunction compared to the patients with diabetes free of diastolic dysfunction. …”
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C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients by Valeria Guaschino, Donata Santarsiero, Sara Gastoldi, Joshua M. Thurman, V. Michael Holers, Shelia M. Violette, Fei Liu, Kelly C. Fahnoe, Chiara Guarinoni, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello

“…To this purpose we tested their capability to block C3 deposition and C5b-9 formation on microvascular endothelial cells (HMEC-1) exposed to serum from patients with aHUS. …”
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The Junction of Allergic Inflammation and Atherosclerosis: Pathways and Clinical Implications—A Review by Mihaela Valcovici, Mihai Sorin Iacob, Abhinav Sharma, Ana Maria Pah, Lucretia Marin-Bancila, Marcel Mihai Vaduva Berceanu, Milan Daniel Velimirovici, Anca-Raluca Dinu, Simona Ruxanda Drăgan, Nilima Rajpal Kundnani

“…Epidemiological studies and review articles were included. <b>Results</b>: Emerging evidence suggests that allergic inflammation contributes to atherosclerosis through interconnected mechanisms such as eosinophil activation, reactive oxygen species production, mast cell degranulation, and endothelial dysfunction. …”
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Tumor-derived immunoglobulin-like transcript 3 inhibition reshapes the immunosuppressive tumor microenvironment and potentiates programmed cell death ligand 1 blockade immunotherap... by Leirong Wang, Qing Li, Yanxin Sun, Shuyun Wang, Xuebing Fu, Xiufen Wang, Yan Zheng, Aiqin Gao, Yuping Sun, Juan Li

“…In vitro assays demonstrated that tumor-derived ILT3/APOE promoted recruitment and M2-like polarization of TAMs in LUAD and directly inhibited T cell proliferation and cytotoxicity. In vivo knockdown of gp49b enhanced anti-tumor immunity and suppressed tumor progression by counteracting TAM- and dysfunctional T cell-induced tumor microenvironment immunosuppression. …”
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The effect of a complex of melatonin, aluminum oxide and polymethylsiloxane on the cellular composition of the mice spleen kept in round-the-clock lighting conditions by A. V. Shurlygina, S. V. Michurina, L. N. Rachkovskaya, A. E. Serykh, S. M. Miroshnichenko, E. E. Rachkovsky, M. A. Korolev, A. Yu. Letyagin

“…The administration of pure and modified melatonin (Complex M) to animals kept under round-the-clock lighting conditions has an equally pronounced normalizing effect on the cellular composition of B- (CD19) and T- (CD3) lymphocytes of the spleen, bringing the values of the studied parameters to the control values of the intact animals (p ≤ 0.001) Round-the-clock lighting affects the proliferative potential of splenocytes, reducing the number of cells in the G2/M phase, compared with animals treated with melatonin (p ≤ 0.050). …”
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Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

“…PATJ maintains brain cell integrity, MINDY1 regulates gene expression, CDKN1B controls the cell cycle and ABCC8 regulates glucose levels. …”
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Ginsenoside C-K inhibits Aβ oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions by Chenghu Xie, Cunxin Zhang, Kefeng Zhang, Shanshan Zhang

“…Results: GCK pretreatment significantly ameliorated Aβ₁₋₄₂ oligomer-induced BV2 cell dysfunction (viability recovery rate >80 %, p < 0.01), suppressed pro-inflammatory cytokine secretion (TNF-α reduced by 62.3 %, IL-1β by 57.8 %), and inhibited NF-κB pathway activation (p-IκBα/p-p65 expression downregulated >50 %). …”
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Effect of experimental gestational diabetes and administration of glibenclamide on mRNA level of NLRP3-inflammasome and distribution of NLRP3+-cells in mesenteric lymph nodes in pr... by Т. М. Prozorova, V. A. Kamyshna, О. М. Kamyshnyi

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