Ex Vivo Tools and Models in MASLD Research by Rallia-Iliana Velliou, Eirini Giannousi, Christiana Ralliou, Eva Kassi, Antonios Chatzigeorgiou

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Cyanamide Potentiates the Ethanol-Induced Impairment of Receptor-Mediated Endocytosis in a Recombinant Hepatic Cell Line Expressing Alcohol Dehydrogenase Activity by Dahn L. Clemens, Dean J. Tuma, Carol A. Casey

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Ethyl Acetate Fraction of Chestnut Honey Attenuates Scopolamine-Induced Cognitive Impairment in Mice and Glutamate-Induced Neurotoxicity in HT22 Cells by Yun Hee Jeong, Wei Li, Hye Jin Yang, Se-Gun Kim, Hong Min Choi, Jang-Gi Choi, You-Chang Oh

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Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest by Zhijian Li, Huiran Qiu, Wenxia Lu, Namin Duan, Shule Fan, Rui Zhou, Xiangzhi Li, Hua Zhang, Ning Liu, Feifei Yang

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Single Cell Transcriptomic Profiling of MYBPC3‐Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression by Samia A. Ali, Gayani Perera, Jason Laird, Rebecca Batorsky, Martin S. Maron, Victor N. Rivas, Joshua A. Stern, Samantha Harris, Michael T. Chin

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MiR-27a-3p protects against NaAsO2-induced neuronal apoptosis in HT22 cells by Qiyao Zhang, Siqi Zhao, Teng Ma, Yujie Wang, Shiqing Xu, Suhua Wang, Xiaohui Wang, Li Wang

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A PI3K Inhibitor with Low Cardiotoxicity and Its Synergistic Inhibitory Effect with Gilteritinib in Acute Myelogenous Leukemia (AML) Cells by Tianze Wu, Yi Chen, Yimin Gong, Mingzhu Lu, Chengbin Yang, Yannan Yang, Yun Ling, Yaming Zhou

“…The synergistic cytotoxicity of FD274 with Gilteritinib was evaluated in the HL-60 cell line and the FLT3-ITD cell line MV-4-11. FD274 demonstrated lower adverse effects associated with cardiac dysfunction, oxidative stress, and myocardial injury in the C57BL/6 mouse model and in the H9C2 cell line as compared with FD268. …”
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Enhanced Detection of Mitochondrial Heteroplasmy and DNA Hypomethylation in Adipose-Derived Mesenchymal Stem Cells Using a Novel Adaptive Sampling Protocol by Antonina Gospodinova, Yuliia Mariienko, Diana Pendicheva-Duhlenska, Soren Hayrabedyan, Krassimira Todorova

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Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM‐1 cell adhesion molecules by Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue, Thomas Nipoti, Stephane Mazlan, Maribel Lara Corona, Florent Dingli, Damarys Loew, Guillaume vanNiel, Xavier Loyer, Chantal M. Boulanger

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CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway by Qianguang Han, Bin Ni, Wei Bao, Junqi Zhang, Ming Zheng, Jinxu Miu, Zijie Wang, Jingwen Yuan, Jun Tao, Zhijian Han, Min Gu, Xiaobing Ju, Ruoyun Tan

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GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development by Jun Ma, Peng Yang, Zhibin Zhou, Tengfei Song, Liang Jia, Xiaofei Ye, Wei Yan, Jiuyi Sun, Tianwen Ye, Lei Zhu

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EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. by Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E Gendelman, Mary Jane Potash, David J Volsky

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Peptidoglycan derived from Lacticaseibacillus rhamnosus and Lactobacillus acidophilus suppress TLR2/1-mediated inflammation in bovine endometrial epithelial cells by Elham Waehama, Elham Waehama, Kenji Fukuda, Alireza Mansouri, Malinda Hulugalla, Ihshan Akthar, Mohamed Samy Yousef, Mohamed Samy Yousef, Akio Miyamoto

“…Bacteria and associated products are factors in the pathogenesis of bovine endometrial inflammation, contributing to reproductive dysfunction. While peptidoglycan derived from Staphylococcus aureus (PGN-Sa) has been demonstrated to induce pro-inflammatory responses and disrupt sperm–immune interactions in bovine endometrial epithelial cells (BEECs) via Toll-like receptor 2/1 (TLR2/1), the immunomodulatory potential of peptidoglycan from lactic acid bacteria (LAB) within the female reproductive tract remains unexplored. …”
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Identifying iNOS and glycogen as biomarkers for degenerated cerebellar purkinje cells in autism spectrum disorder: Protective effects of erythropoietin and zinc sulfate. by Abdulaziz M Al-Garni, Sara A Hosny, Faris Almasabi, Ayed A Shati, Norah M Alzamil, Asmaa M ShamsEldeen, Asmaa A El-Shafei, Fahaid Al-Hashem, Hind Zafrah, Amro Maarouf, Bahjat Al-Ani, Ismaeel Bin-Jaliah, Samaa S Kamar

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Reproductive Challenges in Ruminants Under Heat Stress: A Review of Follicular, Oocyte, and Embryonic Responses by Danisvânia Ripardo Nascimento, Venância Antonia Nunes Azevedo, Regislane Pinto Ribeiro, Gabrielle de Oliveira Ximenes, Andreza de Aguiar Silva, Efigênia Cordeiro Barbalho, Laryssa Gondim Barrozo, Sueline Cavalcante Chaves, Maria Samires Martins Castro, Erica Costa Marcelino, Leopoldo Rugieri Carvalho Vaz da Silva, André Mariano Batista, José Roberto Viana Silva

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Cu-DHM nanozymes treat flap ischemia-reperfusion injury by amplifying immune modulation in a cascade manner and inhibiting cell apoptosis by Xinyu Zhao, Shuo Zhang, Min Wang, Qingrong Li, Xiaolong Wei, Xu-Lin Chen, Xianwen Wang

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Cardiotoxicity Assessment of EGFR Tyrosine Kinase Inhibitors Using Human iPS Cell‐Derived Cardiomyocytes and FDA Adverse Events Reporting System by Shota Yanagida, Hiroyuki Kawagishi, Mitsuo Saito, Hirofumi Hamano, Yoshito Zamami, Yasunari Kanda

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Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease by Jiang H, Zhang X, Feng S, Feng W

“…Finally, DDIT4 expression was validated in PD cell and mouse models.Results: We identified four key ISR-related genes (DDIT4, GNA13, HSPA1B, and SLC7A5) that were differentially expressed in PD microglia. …”
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CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation by Jin-Sil Park, Jin-Sil Park, Jin-Sil Park, Hye Yeon Kang, Hye Yeon Kang, Hye Yeon Kang, Ha Yeon Jeong, Ha Yeon Jeong, SeungCheon Yang, JeongWon Choi, JeongWon Choi, JeongWon Choi, Sang Hee Cho, Sang Hee Cho, Sang Hee Cho, Sol Kim, Bo-In Lee, Mi-La Cho, Mi-La Cho, Mi-La Cho

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Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions by Zoofa Zayani, Arash Matinahmadi, Alireza Tavakolpournegari, Seyed Hesamoddin Bidooki

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