Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets by Ivan I. Dedov, Vsevolod A. Tkachuk, Nikolai B. Gusev, Vladimir P. Shirinsky, Aleksandr V. Vorotnikov, Tatiana N. Kochegura, Aleksander Y. Mayorov, Marina V. Shestakova

Get full text

The crosstalk between insulin resistance, systemic inflammation, redox imbalance and the thyroid in subjects with obesity by Nicoleta Răcătăianu, Nicoleta Valentina Leach, Sorana D. Bolboacă, Maria Loredana Soran, Mirela Flonta, Ana Valea, Andrada-Luciana Lazăr, Cristina Ghervan

Get full text

Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells by Zhao-Qing Shen, Wen-Tai Chiu, Cheng-Heng Kao, Yu-Chen Chen, Li-Hsien Chen, Tsai-Wen Teng, Shao-Yu Hsiung, Tsai-Yu Tzeng, Chien-Yi Tung, Chi-Chang Juan, Ting-Fen Tsai

Get full text

The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer by Jiayi Wang, Jiayao Ma, Shiying Lei, Yulei Zhai, Yangjie Liao, Chongrong Hu, Jingbo Li

“…The low-risk group exhibited enriched immune infiltration, elevated HLA expression, higher dysfunctional T-cell scores, and lower tumor mutation burden, suggesting an exhausted tumor immune microenvironment which could benefit from immunotherapy. …”
Get full text

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. by Sherylanne Newton, Fanbo Kong, Adam J Carlton, Carlos Aguilar, Andrew Parker, Gemma F Codner, Lydia Teboul, Sara Wells, Steve D M Brown, Walter Marcotti, Michael R Bowl

“…In contrast, we find that Nptn-knockout mice have significantly reduced maximal MET currents and MET channel open probabilities in mature OHCs, with both OHCs and IHCs also failing to develop fully mature basolateral currents. Furthermore, comparing the hearing thresholds and IHC synapse structure of Nptn-knockout mice with those of mice that lack Nptn only in IHCs and OHCs shows that the majority of the auditory deficit is explained by hair cell dysfunction, with abnormal afferent synapses contributing only a small proportion of the hearing loss. …”
Get full text

Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

Get full text

Cancer treatment-related xerostomia: basics, therapeutics, and future perspectives by Mohammad-Salar Hosseini, Sarvin Sanaie, Ata Mahmoodpoor, Saba Jabbari Beyrami, Hossein Jabbari Beyrami, Shirin Fattahi, Farid Jahanshahlou, Mahdi Zarei, Alireza Rahimi Mamaghani, Mahshid Kuchaki Rafsanjani

Get full text

Features of correction of metabolic disorders in women with polycystic ovary syndrome by O.V. Bulavenko, D.G. Konkov, O.A. Taran, O.V. Furman, V.V. Klivak

Get full text

Development of an immune-related gene signature applying Ridge method for improving immunotherapy responses and clinical outcomes in lung adenocarcinoma by Zhen Chen, Yongjun Zhang

Get full text

Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes by Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Bijender Kumar, Natthakan Thongon, Feiyang Ma, Kelly S. Chien, Yi J. Kim, Hui Yang, Sanam Loghavi, Roselyn Tan, Vera Adema, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Gheath Al-Atrash, Rafael Bejar, Pinaki Prosad Banerjee, Sophia Lynn Cha, Guillermo Montalban-Bravo, Max Dougherty, Maria Claudina Fernandez Laurita, Noelle Wheeler, Baosen Jia, Eirini P. Papapetrou, Franco Izzo, Daniela E. Dueñas, Salome McAllen, Yiqian Gu, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Abhinav Jain, Koichi Takahashi, Karen Clise-Dwyer, Stephanie Halene, Maria Teresa Sabrina Bertilaccio, Guillermo Garcia-Manero, May Daher, Simona Colla

Get full text

Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury by Yajing Li, Yingxue Ding

Get full text

Targeting autophagy for breast cancer prevention and therapy: From classical methods to phytochemical agents by Sadegh Rajabi, Heeva Shakib, Nahid Safari-Alighiarloo, Marc Maresca, Maryam Hamzelo Moghadam

Get full text

Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS by Valentina Naef, Devid Damiani, Rosario Licitra, Maria Marchese, Stefania Della Vecchia, Matteo Baggiani, Letizia Brogi, Daniele Galatolo, Silvia Landi, Filippo Maria Santorelli

Get full text

Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue by Margo P. Emont, Adam L. Essene, Anton Gulko, Nadejda Bozadjieva-Kramer, Christopher Jacobs, Soumya Nagesh, Randy J. Seeley, Linus T. Tsai, Evan D. Rosen

Get full text

Develop a prognostic and drug therapy efficacy prediction model for hepatocellular carcinoma based on telomere maintenance-associated genes by Jian-Hao Zheng, Ding Shi, Yun-Jie Chen, Jian-Ping Liu, Zheng Zhou

Get full text

Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasionResearch in context by Berta Segura-Collar, Lucia Mondejar-Ruescas, Denisse Alcivar-López, María Garranzo-Asensio, Pablo Mata-Martinez, Ramón Garcia-Escudero, Aurelio Hernández-Laín, Juan M. Sepúlveda, Ángel Pérez Nuñez, Jesús Avila, Pilar Sánchez-Gómez, Ricardo Gargini

Get full text

Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer by Hyo Jin Kim, Ui Ri An, Han Jee Yoon, Hyun Lim, Ki Eun Hwang, Young Suk Kim, Hak Ryul Kim

Get full text

STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights by Lei Li, Guangzhi Zhang, Zhili Yang, Zhenyu Cao, Dongxin Wang, Xuewen Kang

Get full text

Integrins in Cardiovascular Health and Disease: Molecular Mechanisms and Therapeutic Opportunities by Karolina Ławkowska, Klaudia Bonowicz, Dominika Jerka, Yidong Bai, Maciej Gagat

Get full text

Cetylpyridinium chloride disrupts maternal-to-zygotic transition during early embryonic development by impairing mitochondrial function and histone modification by Caiyun Wu, Zhiming Ding, Xuanxi Li, Yan Xu, Huilei Chen, Hongzhen Ruan, Ping Zhou, Zuying Xu, Huifen Xiang

Get full text