Role of astrocytes in the pathogenesis of perinatal brain injury by Ling Li, Xuewei Cui, Baoli Zhu, Lele Zhou, Yaya Guo, Tianjing Liu, Yongyan Shi

“…In response to perinatal brain injury, astrocytes release inflammatory mediators that drive neuroinflammation, disrupting normal brain development. Key signaling pathways, including Janus kinase/signal transducers and activators of transcription (JAK/STAT), nuclear factor kappa B (NF-κB), Notch, and glutamate transporter signaling, are activated during this process, contributing to astrocyte dysfunction and neuronal damage. …”
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Performance of the 1 h oral glucose tolerance test in predicting type 2 diabetes and association with impaired β-cell function in Asians: a national prospective cohort studyResearc... by Michelle H. Lee, Eveline Febriana, Maybritte Lim, Sonia Baig, Liang Shen, Mayank Dalakoti, Nicholas Chew, Tze Ping Loh, Mark Chan, Kee Seng Chia, Alice Pik-Shan Kong, Alex R. Cook, Jeffrey B. Halter, Faidon Magkos, Sue-Anne Toh

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A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15. scFvB1IL15 was tested in vitro on peripheral blood mononuclear cells (PBMCs) obtained from both different healthy donors (HDs) and CLL patients in order to evaluate its ability to target NK cells and enhance their activation and NK-mediated directed cytotoxicity. scFvB1IL15 specifically induced strong degranulation and cytokine and chemokine production in NK cells in both HD- and CLL patient-derived PBMC samples. …”
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Mechanisms of Lung Cancer Development in Cystic Fibrosis Patients: The Role of Inflammation, Oxidative Stress, and Lung Microbiome Dysbiosis by Raffaella Pagliaro, Filippo Scialò, Angela Schiattarella, Roberta Cianci, Susan F. M. Campbell, Fabio Perrotta, Andrea Bianco, Giuseppe Castaldo

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Vav family exchange factors: Potential regulator in atherosclerosis by Yu Zhang, Yongwei Ren, Tao Zhou, Zhengtao Qian, Zhengyang Bao

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Recombinant human urinary trypsin inhibitor improves the immunological function of splenic dendritic cells in mice with acute lung injury by Tong Wang, Wenna Liu, Jun Li, Yongli Wan, Hang Su, Anlong Qi

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Unraveling the deadly dance: endothelial cells and neutrophils in sepsis-induced acute lung injury/acute respiratory distress syndrome by Xiujuan Xu, Xiujuan Xu, Qi Zhang, Zheng Lv, Chuji Cheng, Junjing Zha, Huaqing Shu, Huaqing Shu, Hairong Xiao, Hairong Xiao, Hairong Xiao, Shangwen Pan, Shangwen Pan

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Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury by Lei Wang, Zhong-Yao Li, Chong-Lei Zhong, Zi-Yang Teng, Bin Wang, Asma Rehman, Li-Wen Han, Ke-Wu Zeng, Ji-Guo Zhang, Zhi-Yuan Lu

“…In mechanism, Z-CDs effectively reduced ROS production, thereby alleviating inflammatory responses in macrophages through the suppression of the NF-κB pathway. Conclusions This study developed a multifunctional nanomedicine derived from traditional medicinal herb, providing a promising pathway for the advancement of innovative drug therapies to treat SA-AKI.…”
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Some Aspects of Vascular Theory of Development and Progression of Primary Open-Angle Glaucoma (Literature Review). Part 1 by S. I. Makogon, A. S. Makogon

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Construction of Triphenylamine-Based Aggregation-Induced Emission Luminogens for Lysosomes Imaging and Its Application in the Photodynamic Therapy of Cancer Cells by Zhanguo Sun, Bin Liu, Huijun Liu

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Exhaled breath particles as a diagnostic tool for bronchiolitis obliterans syndrome in lung transplant recipients: a longitudinal study by Runchuan Gu, Runchuan Gu, Runchuan Gu, Embla Bodén, Embla Bodén, Embla Bodén, Embla Bodén, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Franziska Olm, Franziska Olm, Franziska Olm, Franziska Olm

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Fatty liver index and risk of type 2 diabetes of adults with normoglycemia: Insights into insulin sensitivity and beta-cell function. by Ji Hyun Bae, Min Jin Lee, Su Hyun Kim, Joo Yeon Kim, Ah Reum Khang, Yang Ho Kang, Dongwon Yi

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Sex-Related Differences in Heart Failure Development in Patients After First Myocardial Infarction: The Role of Galectin-3 by Milica Dekleva, Tamara Djuric, Ana Djordjevic, Ivan Soldatovic, Aleksandra Stankovic, Jelena Suzic Lazic, Maja Zivkovic

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Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals by Juan Liu, Jianbin Liu, Hai Li, Liehua Liu, Jing Zheng, Zhimin Huang, Xiaopei Cao, Haipeng Xiao, Yanbing Li

“…In healthy adults, higher SVR was a protective factor for β-cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.…”
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Research progress of microglial surface receptors in perioperative neurocognitive disorders by Chun‐Chun Tang, De‐Xing Liu, Zhao‐Qiong Zhu

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TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. by Lijie Yang, Guanzheng Wang, Yuan Ma, Qiancheng Zhao, He Zhao, Qi Wang, Chonghua Zhong, Chunmei Zhang, Yiming Yang

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TARGETING PRC2 ENHANCES THE ANTITUMOR CYTOTOXIC CAPACITY OF ANTI-CD19 CAR-T CELLS AGAINST HEMATOLOGICAL MALIGNANCIES by MLR Carvalho, CO Andrade, MP Cabral-Piccin, GS Kinker, GAF Vitiello, L Abdo, RAG Cambui, MH Bonamino, TS Medina

“…The limited CAR-T cell efficiency is thought to relate to epigenetic mechanisms involved in T-cell suppression and dysfunction. …”
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Probing mitochondrial peroxynitrite biogenesis by a N-morpholinoarylimine-based iridium(III) complex in drug-induced liver cells by Lingtan Kong, Ling Wang, Zixi Zhang, Liuqi Ye, Daniel Shiu-Hin Chan, Chun-Yuen Wong, Jing Wang, Chung-Hang Leung, Wanhe Wang

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The Association of Serum Level of TGF‐β1 and Clinical Manifestations in Sickle Cell Anemia: A Case‐Control Study by Fatemeh Bakhshipour, Bita Bandar, Fatemeh Bineshfar, Najmeh Nameh Goshay Fard, Azar Babaahmadi, Najmaldin Saki, Kaveh Jaseb

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Melatonin mediates the BMP4/MAPK signaling pathway to alleviate zearalenone-induced abnormal embryonic development in mice by Mengyao Wang, Zhixin Pu, Jing Zhang, Peiwen Wang, Yaxin Chen, Yating Zhu, Hongzhen Ruan, Dongmei Ji, Weiwei Zou, Huiru Cheng, Zhiming Ding, Yunxia Cao, Yajing Liu, Dan Liang

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