Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia. by Courtney D Fitzhugh, Matthew M Hsieh, Darlene Allen, Wynona A Coles, Cassie Seamon, Michael Ring, Xiongce Zhao, Caterina P Minniti, Griffin P Rodgers, Alan N Schechter, John F Tisdale, James G Taylor

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From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy by Vida Bozorgi, Mahnaz Babaahmadi, Mohammad Salehi, Jamshid Vafaeimanesh, Ensiyeh Hajizadeh-Saffar

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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…These immunophenotypes, 8 of which were in B cells, 5 in cDC, 2 in T cell maturation stage, 2 in monocytes, 3 in myeloid cells, 7 in TBNK and 13 in Treg. …”
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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations by Jie Yang, Fanyan Ou, Binbin Li, Lixiong Zeng, Qiuli Chen, Houyu Gan, Jianing Yu, Qian Guo, Jihua Feng, Jianfeng Zhang

“…Programmed Cell Death (PCD) can regulate the enrichment of effector immune cells or regulatory immune cells, providing a new perspective for immunotherapy. …”
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A novel free fatty acid receptor agonist improving metabolic health in Drosophila models by Kashi Brunetti, Elisabetta Catalani, Simona Del Quondam, Nicla Romano, Marcello Ceci, Giuditta Clerici, Marianna Gordin, Gianluca Bianchini, Laura Brandolini, Andrea Aramini, Davide Cervia

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Glutathione Decreases Parkinsonism‐Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells by Elif Güzel, Ayşe Arzu Sayın Şakul, Mustafa Nazıroğlu

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Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells by Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim

“…Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B cells. …”
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Single-cell Analysis Highlights Anti-apoptotic Subpopulation Promoting Malignant Progression and Predicting Prognosis in Bladder Cancer by Linhuan Chen, Yangyang Hao, Tianzhang Zhai, Fan Yang, Shuqiu Chen, Xue Lin, Jian Li

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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

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Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro by Feng Wang, Simon T. Hui, Frank Stappenbeck, Dorota Kaminska, Aldons J. Lusis, Farhad Parhami

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ABL1‒YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis by Tiancheng Mao, Xianjun Xu, Leheng Liu, Yulun Wu, Xiaowan Wu, Wenlu Niu, Dandan You, Xiaobo Cai, Lungen Lu, Hui Zhou

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Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis by Lina M. Garzón, Edgar H. Dominguez, Nancy Janeth Vargas, Luz M. Mejía

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Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure. by Sophie Roetynck, Ally Olotu, Joan Simam, Kevin Marsh, Brigitta Stockinger, Britta Urban, Jean Langhorne

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Molecular mechanisms of diquat-induced brain injury: Insights from network toxicology and single-cell RNA sequencing by Minqi Qiu, Duo Zhao, Huahao Lin, Jinmin Zhao

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Dynamic changes in macrophage populations and resulting alterations in Prostaglandin E2 sensitivity in mice with diet-induced MASH by Madita Vahrenbrink, C. D. Coleman, S. Kuipers, I. Lurje, L. Hammerich, D. Kunkel, J. Keye, S. Dittrich, B. M. Schjeide, R. Hiß, J. Müller, G. P. Püschel, J. Henkel

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Comorbid Cardiovascular Malformation and Type II Mucolipidosis: Clinical Case by Nina V. Fedorova, Natalia V. Zhurkova, Nato D. Vashakmadze, Marina A. Babaykina, Grigory V. Revunenkov, Kirill V. Savostyanov, Olga B. Gordeeva, Leyla S. Namazova-Baranova

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Addressing the pathophysiology of venous thrombosis and chronic kidney disease in sickle cell trait using a mouse model by Fatima Trebak, Mohammad O. Sako, Steven P. Grover, Karnsasin Seanoon, Izabela Pawlinski, Chatphatai Moonla, Michael W. Henderson, Vimal K. Derebail, Dougald M. Monroe, Patrick Ellsworth, Rafal Pawlinski, Malgorzata Kasztan, Nigel S. Key

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Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart. by Julien Vermot, Arian S Forouhar, Michael Liebling, David Wu, Diane Plummer, Morteza Gharib, Morteza Gharib, Scott E Fraser

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Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics by Rashid A. Aldahhan, Amal Ahmed El-Sheikh

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Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease. by Yasuhiro Ogawa, Makoto Tanaka, Miho Tanabe, Toshihiro Suzuki, Tadayasu Togawa, Tomoko Fukushige, Takuro Kanekura, Hitoshi Sakuraba, Kazuhiko Oishi

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