Programmed Cell Death in Heart Failure: Mechanisms, Impacts, and Therapeutic Prospects by Dongda Wu, Donghong Deng, Biao Tang

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Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy by Shujuan Wu, Mengqi Zhou, Huimin Zhou, Lu Han, Huifan Liu

“…Our findings revealed a new mechanism for As in treating sepsis, which involved the reduction of neutrophil extracellular traps (NETs) release, potentially related to As binding with IκBα to inhibit the activation of the NF-κB pathway. …”
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Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells by Cheng Zheng, Jianmin Huang, Shengming Xu, Bin Lu, Hanxin Que, Tianhao Chen, Yubo Hou, Yubo Hou, Linlin He, Linlin He, Xia Fan, Fa-Ming Chen, Yi Wang, Yi Wang, Hui Deng, Hui Deng

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Endothelial Cells and Astrocytes: A Concerto en Duo in Ischemic Pathophysiology by Vincent Berezowski, Andrew M. Fukuda, Roméo Cecchelli, Jérôme Badaut

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A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signalin... by Wan-Yi Guo, Qi-Min Wu, Hao-Feng Zeng, Yu-Lian Chen, Jie Xu, Zhen-Yi Yu, Yong-Kang Shu, Xiao-Nan Yang, Chuan-Hai Zhang, Xi-Zi He, Jia-Ning Mi, Si Chen, Xiao-Man Chen, Jia-Qi Wu, He-Quan Yao, Liang Liu, Hu-Dan Pan

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Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway by Xiaohui Liu, Shuai Chen, Xing Liu, Xianxian Wu, Xiaoliang Jiang, Yuhan Li, Zhiwei Yang

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Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies by Reshmi Nair, Veena Somasundaram, Anshu Kuriakose, Shiv Ram Krishn, David Raben, Rachel Salazar, Pradip Nair

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Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model by Chong Liu, Yan Zhao, Wei Zhang, Ji-Ji Dao, Qian Li, Jia Huang, Zhen-Feng Li, Yu-Ke Ma, Chen-Meng Qiao, Chun Cui, Shuang-Xi Chen, Li Yu, Yan-Qin Shen, Wei-Jiang Zhao

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Flow Cytometric Assessment of FcγRIIIa-V158F Polymorphisms and NK Cell Mediated ADCC Revealed Reduced NK Cell Functionality in Colorectal Cancer Patients by Phillip Schiele, Stefan Kolling, Stanislav Rosnev, Charlotte Junkuhn, Anna Luzie Walter, Jobst Christian von Einem, Sebastian Stintzing, Wenzel Schöning, Igor Maximilian Sauer, Dominik Paul Modest, Kathrin Heinrich, Lena Weiss, Volker Heinemann, Lars Bullinger, Marco Frentsch, Il-Kang Na

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Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance by Xinni Xue, Zhiwei Li, Jiahui Zhao, Ziyi Zhao, Zhihang Li, Yong Li, Yawen Liu, Huan He

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Signaling pathways of β-cell death in type 2 diabetes mellitus: the role of innate immunity by Zilya. A. Kalmykovа, Irina V. Kononenko, Olga M. Smirnova, Marina Vladimirovna Shestakova

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RECURRENT CORNEAL EROSION SYNDROME (a review) by S. V. Trufanov, S. A. Malozhen, E. G. Polunina, E. A. Pivin, L. Yu. Tekeeva

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Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches by Wei He, Panli Tang, Hongbin Lv

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Unravelling the pathways driving tumour growth and resistance by Abraham Ubhenin, Joshua Ikebuiro, Osayemwenre Erharuyi, Yusuf Abdulmalik, Tyem Danjuma

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Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools by Jared Klarquist, Zhenyuan Zhou, Nan Shen, Edith M. Janssen

“…SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies. …”
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Association analysis between circulating methylmalonic acid and cognitive performance: a population-based cross-sectional study by Chao Wang, Chao Wang, Wenwei Guo, Yan Xue, Yan Xue, Li Xu, Li Xu

“…BackgroundCognitive impairment is one of the common manifestations of abnormal development or dysfunction of the nervous system. Methylmalonic acid (MMA) is a dicarboxylic acid in the propionate metabolism pathway involving vitamin B12 (B12), it is also one of the commonly used biomarkers in human B12 testing. …”
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Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review by César Galván, Rafael Durán, Cristian Matos, Cristiana Indolfi, Angela Klain

“…Atopic children exhibit markedly higher bacterial infection rates, with 27.1% showing Mycoplasma pneumoniae involvement versus 4.9% in non-atopic children. <b>Conclusions:</b> Recurring infections in allergic pediatric patients result from significant immune dysfunction involving altered cytokine production and immune cell function. …”
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Exosome-derived miR-548ag drives hepatic lipid accumulation via upregulating FASN through inhibition of DNMT3B by Xiaolong Chu, Yanting Hou, Chaoling Peng, Wei Li, Maodi Liang, Jin Mei, Meiyu Qian, Juan Wang, Shibo Xu, Yidan Jiang, Xin Wen, Yao Chen, Fangyuan Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…In vitro studies in HepG2 and L02 cells, along with previous findings, demonstrated that miR-548ag promotes fatty acid synthase (FASN) expression by inhibiting DNA methyltransferase 3B (DNMT3B), thereby enhancing lipid synthesis. …”
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Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility by Rui Feng, Dexin Cheng, Wei Zhang, Jiayun Zhang, Sixiang Chen, Yan Xia

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Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification by Ae-Rang Hwang, Chang-Hoon Woo

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