Heimler Syndrome With Tooth Agenesis, Abnormal Enamel and Dentin Mineralization, Root Maldevelopment, and PEX1 Mutation by Piranit N. Kantaputra, Atitaya Apivatthakakul, Massupa Kaewgahya, Sissades Tongsima, Chumpol Ngamphiw, Thanapat Sastraruji, Panwarit Sukantamala, Bruce M. Carlson, Katsushige Kawasaki, James R. Ketudat Cairns, Nuntigar Sonsuwan, Atsushi Ohazama

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Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding by Gabriel Ocana-Santero, Hannah Warming, Veronica Munday, Heather A. MacKay, Caius Gibeily, Christopher Hemingway, Jacqueline A. Stacey, Abhishek Saha, Ivan P. Lazarte, Anjali Bachetta, Fei Deng, Yulong Li, Adam M. Packer, Trevor Sharp, Simon. J. B. Butt

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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…We examine the evidence that highlights how dysfunctions in PERs activities initiate cancer development, aid tumor growth, and modify cancer cell metabolism through pathways involved in oxidative stress and immune system. …”
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Factors of angiogenesis in the development of physiological and pathological processes of the female gonads by V. G. Zenkina

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Integrating mitochondrial and lysosomal gene analysis for breast cancer prognosis using machine learning by Huilin Chen, Zhenghui Wang, Jiale Shi, Jinghui Peng

“…We found that the overall immunoinfiltration of immune cells was decreased in the high-risk group, it was specifically noted that B cell mlMSGs activity remained diminished in high-risk patients. …”
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Deep phenotyping of a modified diabetic cardiomyopathy mouse model which reflects clinical disease progression by Narainrit Karuna, Lauren Kerrigan, Kevin Edgar, Oisin Cappa, David Simpson, Claire Tonry, David J. Grieve, Chris J. Watson

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Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine by Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen

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Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish by Kemin Chen, Jieyi Wu, Yuxian Zhang, Wei Liu, Xiaohui Chen, Wenqing Zhang, Zhibin Huang

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The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Dou Shi, Mo Zhang, Yuhan Zhang, Yang Shi, Xing Liu, Xianxian Wu, Zhiwei Yang

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Epinephrine, but not dexamethasone, induces apoptosis in human retinal pigment epithelium cells in vitro: Possible implications on the pathogenesis of central serous chorioretinopa... by Santiago Antonio B. Sibayan, MD, PhD, Karin Kobuch, MD, Detlev Spiegel, MD, Elfriede Eckert, MTA, Rita Leser, MTA, Jan Monzer, PhD, Veit-Peter Gabel, MD

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Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ by Andrew Shultz, Anna Vincze, Todd T. Yau, Emma L. Poirier, Hannah Demanche, Jennifer N. Rauch

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Chimeric Antigen Receptor-Modified Immune Cells for Eradication of HIV Reservoirs by Guo-Fen Re, Bei-Bei Tang, Jing Kou, Chen Hong, Yi-Qun Kuang

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Mechanisms underlying targeted mitochondrial therapy for programmed cardiac cell death by Fengting Jing, Min Zhao, Hemin Xiong, Xin Zeng, Jun Jiang, Tao Li

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Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease. by Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll

“…To study the relationship between peripheral huntingtin levels and striatal HD phenotypes, we utilized a knock-in model of the human HD mutation (the B6.HttQ111/+ mouse). We treated mice with ASOs from 2-10 months of age, a time period over which significant HD-relevant signs progressively develop in the brains of HttQ111/+ mice. …”
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Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies by Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice, Michela Cecere, Francesca Romana Pesci, Guido Ripandelli, Alessandra Micera

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Inflammation and cancer cell survival: TRAF2 as a key player by Adriana Albini, Luisa Di Paola, Giampiero Mei, Denisa Baci, Nicola Fusco, Giovanni Corso, Douglas Noonan

“…In the innate immune system, TRAF2 influences macrophage differentiation, activation, and survival and stimulates natural killer cell cytotoxicity. In the adaptive immune system, it represses effector B- and T-cell activity while sustaining regulatory T-cell function, thus promoting immune suppression. …”
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Non-parenchymal cells: key targets for modulating chronic liver diseases by Tongwang Yang, Zhiyun Gu, Juan Feng, Juanjuan Shan, Cheng Qian, Na Zhuang

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Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control by Jiaying Yang, Yawen Li, Ying Huang, Huaiyong Chen, Pengfei Sui

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Osteoimmunology: an interdisciplinary approach to studying the relationships between immune and bone cells by V. S. Shirinsky, I. V. Shirinsky

“…The data are presented on regulatory molecular pathways of bone marrow cell activity, T and B cells, macrophages, and formation of “endosteal niche” by the bone cells. …”
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TNIK-driven regulation of ERK5 transcriptional activity in endothelial cells by Venkata Subrahmanya Kumar Samanthapudi, Sivareddy Kotla, Nhat-Tu Le

“…Extracellular signal-regulated kinase 5 (ERK5) is essential for cardiovascular development and endothelial cell (EC) function. Activation of ERK5 through MEK5-mediated phosphorylation at threonine 218 and tyrosine 220 (T218/Y220) drives the transcriptional activation of myocyte enhancer factor-2 (MEF2), promoting the expression of KLF2 and KLF4—key transcription factors that maintain vascular homeostasis. …”
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