A case report of bioprosthetic valve dysfunction after tricuspid valve replacement in a preschool patient: the contribution of pannus and calcification by T. V. Glushkova, E. A. Ovcharenko, A. V. Batranin, K. Yu. Klyshnikov, Yu. A. Kudryavtseva, L. S. Barbarash

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Neutrophil Myo5c gene downregulation is associated with postoperative organ dysfunction following pediatric cardiac surgery with cardiopulmonary bypass by Wiriya Maisat, Wiriya Maisat, Wiriya Maisat, Wiriya Maisat, Sumiti Sandhu, Samuel Kim, Hanna Van Pelt, Sek Won Kong, Sek Won Kong, Juan Ibla, Juan Ibla, Koichi Yuki, Koichi Yuki, Koichi Yuki, Koichi Yuki

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Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. by Eillen J Rodriguez-Franco, Yisel M Cantres-Rosario, Marines Plaud-Valentin, Rafael Romeu, Yolanda Rodríguez, Richard Skolasky, Viviana Meléndez, Carmen L Cadilla, Loyda M Melendez

“…The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal dysfunction and cell death associated with HAND. One potentially neurotoxic protein secreted by HIV-1 infected macrophages is cathepsin B. …”
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Passenger Lymphocyte Syndrome and Autoimmune Hypothyroidism Following Hematopoietic Stem Cell Transplantation by Denis F. Noubouossie, Mohammed I. A. Zaanona, Luciano J. Costa, Huy P. Pham, Marisa B. Marques, Antonio Di Stasi

“…We present the case of a 24-year-old male, who received a minor ABO-incompatible allogeneic hematopoietic stem cell transplant (HSCT, blood group O+ ⟶ A+) from an HLA-matched unrelated female donor, as consolidation therapy for relapsed precursor-B-cell acute lymphoblastic leukemia. …”
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Correlation of Vitamin B12 Levels with Clinical and Laboratory Features in Patients of Dengue Fever by Asma Abdul Razzak

“…The creation of DNA, the genetic information-carrying molecules found inside cells, as well as the metabolism of cells, neuron function, and red blood cell development all depend on vitamin B-12.6 Measurements of serum or plasma vitamin B12 levels are commonly used to determine vitamin B12 status. …”
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Correlation of Vitamin B12 Levels with Clinical and Laboratory Features in Patients of Dengue Fever by Asma Abdul Razzak

“…The creation of DNA, the genetic information-carrying molecules found inside cells, as well as the metabolism of cells, neuron function, and red blood cell development all depend on vitamin B-12.6 Measurements of serum or plasma vitamin B12 levels are commonly used to determine vitamin B12 status. …”
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Refractive Development in the “ROP Rat” by Toco Y. P. Chui, David Bissig, Bruce A. Berkowitz, James D. Akula

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THYROID STATUS AND ITS CORRELATION WITH THE FUNCTIONAL ACTIVITY OF IMMUNOCYTES by V. V. Zdor, E. V. Markelova, B. I. Geltser

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T CELL AGING IN RHEUMATOID ARTHRITIS by Maria Oubaid, Bushra tahreem, Toba Samreen, Javeria Parveen, Idress Khan

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Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson’s disease through inhibition of H3K4me3 demethylation by Xiaoyuan Zhang, Fali Zhang, Yue Zeng, Aiying Li, Jiamao Yan, Pei Li, Kexin Qin, Teng Zhang, Jiaojiao Huang, Minghui Zhao, Massimo De Felici, Yang Zhou, Wei Shen

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Transcriptional regulation of male-sterility in 7B-1 male-sterile tomato mutant. by Vahid Omidvar, Irina Mohorianu, Tamas Dalmay, Yi Zheng, Zhangjun Fei, Anna Pucci, Andrea Mazzucato, Vendula Večeřová, Michaela Sedlářova, Martin Fellner

“…The present study provides insights into the transcriptome of the 7B-1 mutant. We identified several genes with altered expression level in 7B-1 (including beta-1,3 glucanase, GA2oxs, cystatin, cysteine protease, pectinesterase, TA29, and actin) that could potentially regulate anther developmental processes, such as meiosis, tapetum development, and cell-wall formation/degradation.…”
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Butyric acid ameliorates PCOS-related reproductive dysfunction through gut-brain-ovary axis signaling and ovarian steroidogenic factor activation by Xueping Feng, Xueping Feng, Juan Xiao, Decai Wang, Xianzhao Fu, Jie Gao, Minli Jiang, Jin Li, Lihe Jiang, Xingwei Liang, Yanna Huang, Qinyang Jiang

“…Proteomic analysis and cell experiments suggested that upregulation of Cytochrome P450 1b1 (Cyp1b1) may play a crucial role in regulating E2 metabolism and P4 production, potentially contributing to the pathogenesis of PCOS and ovarian dysfunction.ConclusionThese findings indicate that NaBu may exert its regulatory effects on appetite and hormone levels in the hypothalamus through the gut-brain-ovary axis, modulating the expression of ovarian steroidogenic factors, thereby improving follicular development and granulosa cell function, and enhancing reproductive performance.…”
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MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells by Ding F, Zhang W, Liu T, Rong X, Cui Y, Meng L, Wang L, Liu B, Li M

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Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) by Adolfo Toledano, Arantxa Rodríguez-Casado, María Isabel Älvarez, Adolfo Toledano-Díaz

“…The need for further research in two very different directions is evident: (a) characterization of the phenotypic changes of astrocytes and microglial cells in each region of the brain and in each phase of development of each isolated and associated pathology (single-cell studies are mandatory) to better understand the pathologies and define new therapeutic targets; (b) studying new therapeutic avenues to normalize the function of neuroglial cells (preventing neurotoxic responses and/or reversing them) in these pathologies, as well as the phenotypic characteristics in each moment of the course and place of the neurodegenerative process.…”
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Development of perivascular astrocyte processes by Martine Cohen-Salmon, Naomie Guille, Anne-Cécile Boulay

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From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers by Heather Shaw, Pinkie Chambers, Matthew Watson, Luke Steventon, James Harmsworth King, Angelo Ercia, Noura Al Moubayed

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Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

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КОРРЕКЦИЯ ДИСФУНКЦИИ ЭНДОТЕЛИЯ У ЖЕНЩИН ГРУППЫ РИСКА РАЗВИТИЯ ГЕСТАЦИОННОЙ ГИПЕРТЕНЗИИ by С. А. Матякубова

“…Studies have shown that the development of the GAG and the frequency of hypertensive complications such as preeclampsia (PE) is determined in impaired NO-system and the degree of endothelial dysfunction (ED), which stimulates the vasoconstrictor effect of ET-1, causes endothelial damage and increased in the systemic circulation amount of circulating endothelial cells (CEC). …”
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Temporal RAGE Over-Expression Disrupts Lung Development by Modulating Apoptotic Signaling by Derek M. Clarke, Madison N. Kirkham, Logan B. Beck, Carrleigh Campbell, Hayden Alcorn, Benjamin T. Bikman, Juan A. Arroyo, Paul R. Reynolds

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Persistence of dysfunctional immune response 12 months after SARS-CoV-2 infection and their relationship with pulmonary sequelae and long COVID by Tamara Cruz, Núria Albacar, Estibaliz Ruiz, Gema M. Lledo, Lídia Perea, Alba Puebla, Alejandro Torvisco, Núria Mendoza, Pau Marrades, Jacobo Sellares, Alvar Agustí, Odette Viñas, Oriol Sibila, Rosa Faner

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