To the Future: The Role of Exosome-Derived microRNAs as Markers, Mediators, and Therapies for Endothelial Dysfunction in Type 2 Diabetes Mellitus by Maurice B. Fluitt, Neal Mohit, Kanwal K. Gambhir, Gail Nunlee-Bland

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Breaking the Feedback Loop of β-Cell Failure: Insight into the Pancreatic β-Cell’s ER-Mitochondria Redox Balance by Amira Zaher, Samuel B. Stephens

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Primary Cilia, Hypoxia, and Liver Dysfunction: A New Perspective on Biliary Atresia by Patrícia Quelhas, Diogo Morgado, Jorge dos Santos

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Pathological Mechanisms Involved in HIV-Associated Lymphomagenesis: Novel Targeted Therapeutic Approaches by Mihaela Straista, Francesca Caccuri, Nicoleta Arnaut, Arnaldo Caruso, Mark Slevin

“…Indirect mechanisms based on cytokine dysregulation, HIV-induced immune dysfunction, and co-infections with oncogenic viruses induce chronic B-cell activation and generation of a prone environment for malignant transformation and tumor growth. …”
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A Combined Extract from <i>Dioscorea bulbifera</i> and <i>Zingiber officinale</i> Mitigates PM_2.5-Induced Respiratory Damage by NF-κB/TGF-β1 Pathway by In Young Kim, Hyo Lim Lee, Hye Ji Choi, Yeong Hyeon Ju, Yu Mi Heo, Hwa Rang Na, Dong Yeol Lee, Won Min Jeong, Ho Jin Heo

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Hypoxia-ischemia and sexual dimorphism: modeling mitochondrial dysfunction using brain organoids by Romane Gaston-Breton, Clémence Disdier, Henrik Hagberg, Aloïse Mabondzo

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Ameliorative Mechanism of Malvidin-3-O-glucoside on Chlorpyrifos-Induced PC12 Cell Injury by ZHU Rongchen, JING Shiji, LI Qi, FU Chengguo, HE Yang, WEN Liankui

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Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity by Oleg Varlamov

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Machine Learning Developed a Programmed Cell Death Signature for Predicting Prognosis, Ecosystem, and Drug Sensitivity in Ovarian Cancer by Le Wang, Xi Chen, Lei Song, Hua Zou

“…OC patients with low CDS score had a higher level of CD8+ cytotoxic T, B cell, and M1-like macrophage, representing a related immunoactivated ecosystem. …”
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Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia by Huynh Cao, Jeffrey Xiao, David J. Baylink, Vinh Nguyen, Nathan Shim, Jae Lee, Dave J. R. Mallari, Samiksha Wasnik, Saied Mirshahidi, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Yi Xu

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Stem cell-derived exosomes prevent the development of thoracic aortic aneurysm/dissection by inhibiting AIM2 inflammasome and pyroptosis by Lin Lu, Feng Liu, Weiliang Wu, Yu Zhang, Bin Liu, Qingfang Han, Tonggan Lu, Huiling Zhang, Xi-yong Yu, Yangxin Li

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Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes by Sergio Rutella, Franco Locatelli

“…MM cells have a unique ability to evade immunosurveillance through several mechanisms including, among others, expansion of regulatory T cells (Treg), reduced T-cell cytotoxic activity and responsiveness to IL-2, defects in B-cell immunity, and induction of dendritic cell (DC) dysfunction. …”
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ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction by Chuanmei Qin, Jiayi Wu, Xiaowei Wei, Xueqing Liu, Yi Lin

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Dysfunctional K⁺ Homeostasis as a Driver for Brain Inflammation by Nagihan Ozsoy, Mark L. Dallas

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Tannin alleviated reproductive dysfunction in pregnant ewes infected with Haemonchus contortus by Xin Li, Xin Li, Hai Xiang, Hai Xiang, Rong Liang, Rong Liang, Xinyu Han, Xinyu Han, Rongzhen Zhong, Rongzhen Zhong, Hongyu Liu, Hongyu Liu, Yi Fang, Yi Fang

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Gene Therapy in the Management of Erectile Dysfunction (ED): Past, Present, and Future by Arnold Melman, Kelvin P. Davies

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Pathogenic synergy: dysfunctional mitochondria and neuroinflammation in neurodegenerative diseases associated with aging by Shalini Mani, Samiksha Wasnik, Chesta Shandilya, Vidushi Srivastava, Saboor Khan, Keshav K. Singh

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Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation by Beatrice Uguagliati, Mariagrazia Grilli

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A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction by Jack Sharkey, Lorenzo Ressel, Nathalie Brillant, Lauren Scarfe, Bettina Wilm, B. Kevin Park, Patricia Murray

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Exploring the tumor microenvironment of breast cancer to develop a prognostic model and predict immunotherapy responses by Ye Tian, Yong Yang, Lei He, Xiaocheng Yu, Hu Zhou, Juan Wang

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