Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies by Fei Yu, Yue Zhu, Shenghao Li, Liyuan Hao, Na Li, Fanghang Ye, Zhi Jiang, Xiaoyu Hu

“…Humoral immunity, mediated by B-cell subpopulations, and cellular immunity, dominated by T-cell subpopulations show varying degrees of dysfunction during chronic hepatitis B (CHB). …”
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The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing by Qiuping Lin, Zhen Wang, Guohui Ding, Guang Li, Liqin Chen, Qingzhu Qiu, Sirui Song, Wei Liu, Xunwei Jiang, Min Huang, Min Huang, Libing Shen, Tingting Xiao, Lijian Xie, Lijian Xie, Lijian Xie

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The role of immune cells in the development of adipose tissue dysfunction in cardiovascular diseases by E. G. Uchasova, O. V. Gruzdeva, Yu. A. Dyleva, E. V. Belik, O. L. Barbarash

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Intravascular Hemolysis of Red Blood Cells in the Development of Organ Dysfunctions in Critical Conditions by Yu. I. Orlov

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Characterization of intrahepatic B cells in acute-on-chronic liver failure by Yudong Zhao, Wei He, Chenchen Wang, Nana Cui, Changjie Yang, Zhengrui You, Bisheng Shi, Lei Xia, Xiaosong Chen

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Cell typing of biological heart valves prosthesis explanated due to the development of calcium-associated dysfunctions by R. A. Mukhamadiyarov, N. V. Rutkovskaya, S. G. Rutkovskaya, Yu. N. Odarenko, I. V. Mil’to, L. S. Barbarash

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Anti-HBV treatment partially restores the dysfunction of innate immune cells and unconventional T cells during chronic HBV infection by Yiwen Shu, Yiwen Shu, Sumeng Li, Sumeng Li, Yanqin Du, Yanqin Du, Xin Zheng, Xin Zheng

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DNMT3a-Mediated Enterocyte Barrier Dysfunction Contributes to Ulcerative Colitis via Facilitating the Interaction of Enterocytes and B Cells by Bo Cheng, Ai-mei Rong, Wenlu Li, Xiuqian Bi, Xinguang Qiu

“…Our study suggests that DNMT3a induces enterocyte barrier dysfunction to aggravate UC progression via TNFSF13-mediated interaction of enterocyte and B cells.…”
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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain. by Clorissa L Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S Karuppagounder, Yulemni Morel, Jace W Jones, Alex Zak, Tong Xiao, Tatiana N Boronina, Robert N Cole, Namandjé N Bumpus, Christopher J Chang, Ted M Dawson, Svetlana Lutsenko

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Hsa-miR-146b-3p promotes endothelial cell dysfunction and atherosclerosis development by targeting CREB3L3 to regulate the PI3K/Akt signaling pathway by Shifan ZHOU, Shuming ZHANG, Ningyuan CHEN, Ling HUANG, Chongyang SONG, Shangling PAN, Junhua PENG

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Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome by Cao Z, Zhou Q, An J, Guo X, Jia X, Qiu Y

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Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease by Juan Diego Hernández‐Camacho, Cristina Vicente‐García, Lorena Ardila‐García, Ana Padilla‐Campos, Guillermo López‐Lluch, Carlos Santos‐Ocaña, Peter S. Zammit, Jaime J. Carvajal, Plácido Navas, Daniel J.M. Fernández‐Ayala

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Peroxisomal dysfunction interferes with odontogenesis and leads to developmentally delayed teeth and defects in distinct dental cells in Pex11b-deficient mice. by Claudia Colasante, Julia Jednakowski, Klaus-Peter Valerius, Xiaoling Li, Eveline Baumgart-Vogt

“…To understand the impact of severe peroxisomal dysfunction on early odontogenesis, here we performed morphometric studies on developing molars of new-born Pex11b knockout mice. …”
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IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN by N. A. Khonina, M. A. Tikhonova, I. B. Dzutzeva, N. M. Pasman, A. A. Ostanin, E. R. Chernykh

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NF-κB inhibition attenuates sympathetic hyperreflexia and concomitant development of autonomic dysreflexia and immune dysfunction after spinal cord injury by Micaela L. O’Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Nan Hai, Julien Bouyer, Sandhya Kortagere, Yinghui Zhong, John R. Bethea, Veronica J. Tom

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MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles by Linsey Peters, Leonida Rakateli, Rosanna Huchzermeier, Andrea Bonnin-Marquez, Sanne L Maas, Cheng Lin, Alexander Jans, Yana Geng, Alan Gorter, Marion Gijbels, Sander Rensen, Peter Olinga, Tim Hendrikx, Marcin Krawczyk, Malvina Brisbois, Joachim Jankowski, Kiril Bidzhekov, Christian Weber, Erik AL Biessen, Ronit Shiri-Sverdlov, Tom Houben, Yvonne Döring, Matthias Bartneck, Emiel van der Vorst

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Natural Killer Cell Activation Signature Identifies Cyclin B1/CDK1 as a Druggable Target to Overcome Natural Killer Cell Dysfunction and Tumor Invasiveness in Melanoma by Linbin Chen, Wanqian Liao, Jing Huang, Qiuyue Ding, Junwan Wu, Qiong Zhang, Ya Ding, Dandan Li, Jingjing Li, Xizhi Wen, Xiaoshi Zhang

“…<b>Background/Objectives:</b> Natural killer (NK) cells play a crucial role in immune surveillance against melanoma, yet they frequently exhibit dysfunction in the tumor microenvironment. …”
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Glomerular filtration rate dynamics in patients with diffuse large B-cell lymphoma during induction immunopolychemotherapy by A. S. Nozdricheva, I. B. Lysenko, N. K. Guskova, M. A. Konovalchik, A. A. Maslov, E. V. Shalashnaya

“…The study found that in patients with initially low GFR level, a further, even more pronounced decrease in GFR during pct is observed. at the same time, the absence of significant differences in GFR level depending on disease stage allows us to conclude that the leading role is not so much the stage of the disease and tumor volume, but rather the initial functional status of the kidneys in the development of renal dysfunction in patients with diffuse large B-cell lymphoma during R-CHOP therapy.…”
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High Glucose Promotes the Ferroptosis and Dysfunction of Endothelial Cells by Downregulating SLC3A2 and Promoting the Development of Nephropathy by Yingying Ji, Qi Wang, Jun Wang, Qi Zhang, Ying Jiang, Peipei Luan

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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

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