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  1. 1681

    Neural correlates of human fear conditioning and sources of variability in 2199 individuals by Joaquim Radua, Hannah S. Savage, Enric Vilajosana, Alec Jamieson, Birgit Abler, Fredrik Åhs, Tom Beckers, Narcís Cardoner, Josh M. Cisler, Juliana B. Diniz, Dominik R. Bach, Sigrid Elsenbruch, Steven G. Greening, Daphne J. Holt, Antonia N. Kaczkurkin, Andreas Keil, Merel Kindt, Kathrin Koch, Kevin S. LaBar, Charlene L. Lam, Christine L. Larson, Tina B. Lonsdorf, Christian J. Merz, Katie A. McLaughlin, Yuval Neria, Daniel S. Pine, Carien M. van Reekum, Alexander J. Shackman, Carles Soriano-Mas, Victor I. Spoormaker, Daniel M. Stout, Benjamin Straube, Thomas Straube, Lauri Tuominen, Renée M. Visser, Laura Ahumada, Volker Arolt, Marcelo C. Batistuzzo, Paulo R. Bazán, Emma E. Biggs, Marta Cano, Pamela Chavarría-Elizondo, Samuel E. Cooper, Udo Dannlowski, Víctor de la Peña-Arteaga, Stephanie N. DeCross, Katharina Domschke, Mana R. Ehlers, John L. Graner, Alfons O. Hamm, Martin J. Herrmann, Ashley A. Huggins, Adriane Icenhour, Asier Juaneda-Seguí, Markus Junghoefer, Tilo Kircher, Katja Koelkebeck, Manuel Kuhn, Franziska Labrenz, Shmuel M. Lissek, Martin Lotze, Ulrike Lueken, Jürgen Margraf, Ignacio Martínez-Zalacaín, Robert Moeck, Jayne Morriss, María Ortuño, Andre Pittig, Daniel Porta-Casteras, Jan Richter, Isabelle C. Ridderbusch, Winfried Rief, Kati Roesmann, Jörgen Rosén, Alena N. Rußmann, Rachel Sjouwerman, Jennifer Spohrs, Andreas Ströhle, Benjamin Suarez-Jimenez, Martin Ulrich, Hans-Ulrich Wittchen, Xi Zhu, Lea Waller, Henrik Walter, Paul M. Thompson, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Dan J. Stein, Nic J. Van der Wee, Joseph E. Dunsmoor, Andre F. Marquand, Ben J. Harrison, Miquel A. Fullana

    Published 2025-08-01
    “…We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the “central autonomic–interoceptive” or “salience” network. …”
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  2. 1682
  3. 1683

    Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity by Steven Brem

    Published 2024-12-01
    “…The tumor microenvironment (TME) poses multiple biological hurdles: blood-brain barrier, immune suppression, heterogeneity, and tumor infiltration. Genomic analysis of the senescence-associated secretory phenotype (SASP) and preclinical models of glioma suggest that an exciting approach would entail reprogramming of the glioma microenvironment, attenuating the pro-inflammatory, pro-tumorigenic cytokines of the SASP, especially interleukin-6 (IL-6). …”
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