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Identification of potential metabolic biomarkers and immune cell infiltration for metabolic associated steatohepatitis by bioinformatics analysis and machine learning
Published 2025-05-01“…Results: We successfully identified seven signature MRDEGs, including CYP7A1, GCK, AKR1B10, HPRT1, GPD1, FADS2, and ENO3, through PPI network analysis and machine learning algorithms. The gene model displayed exceptional diagnostic performance in the training and validation cohorts, as evidenced by the area under ROC curve (AUC) exceeding 0.9. …”
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Predicting the risk of gastroparesis in critically ill patients after CME using an interpretable machine learning algorithm – a 10-year multicenter retrospective study
Published 2025-01-01“…The clinical data of critically ill patients transferred to the intensive care unit (ICU) post-CME were meticulously analyzed to identify key risk factors associated with the development of gastroparesis.MethodsWe gathered 34 feature variables from a cohort of 1,097 colon cancer patients, including 87 individuals who developed gastroparesis post-surgery, across multiple hospitals, and applied a range of machine learning algorithms to construct the predictive model. …”
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Identification of GABBR2 as a diagnostic marker and its association with Aβ in Alzheimer's disease
Published 2025-06-01“…The overlapped hub genes were further processed using machine learning algorithms, intersected with module gene from protein-protein interaction (PPI) network constructed with DEGs, to yield co-hub genes. …”
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Association between pro-inflammatory diet and fecal incontinence: a large population-based study
Published 2025-05-01“…Meanwhile, we identified key dietary factors for FI using multiple machine learning algorithms. Finally, we assessed the mediation role of inflammatory indicators on the association of key dietary factors with FI through mediation analysis.ResultsAfter adjustment for potential confounding variables, our results showed the highest tertile exhibited dramatically increasing prevalence of FI compared to the lower tertile (OR 1.27, 95% CI 1.06–1.53), suggesting a positive association between DII and FI. …”
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Assessing the association between ADHD and brain maturation in late childhood and emotion regulation in early adolescence
Published 2025-06-01“…Whether the difference between an individual’s brain age predicted by machine-learning algorithms trained on neuroimaging data and that individual’s chronological age, i.e. brain-predicted age difference (brain-PAD) predicts differences in emotion regulation, and whether ADHD problems add to this prediction is unknown. …”
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Predicting metabolic dysfunction associated steatotic liver disease using explainable machine learning methods
Published 2025-04-01“…Abstract Early and accurate identification of patients at high risk of metabolic dysfunction-associated steatotic liver disease (MASLD) is critical to prevent and improve prognosis potentially. …”
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Identification of Exosome-Associated Biomarkers in Diabetic Foot Ulcers: A Bioinformatics Analysis and Experimental Validation
Published 2025-07-01“…Support vector machine–recursive feature elimination (SVM-RFE) and the Boruta random forest algorithm distilled five biomarkers (DIS3L, EXOSC7, SDC1, STX11, SYT17). …”
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A clustering-based approach for classifying data streams using graph matching
Published 2025-02-01“…This allows for associating clusters in the test network with clusters in the initial network, enabling the labeling of test clusters based on associated clusters in the training set. …”
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Identification of hub genes for the diagnosis associated with heart failure using multiple cell death patterns
Published 2025-08-01“…DHRS11 and LRKK2 were identified as PCD‐associated HF hub genes by machine learning algorithms. …”
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Usability of machine learning algorithms based on electronic health records for the prediction of acute kidney injury and transition to acute kidney disease: A proof of concept stu...
Published 2025-01-01“…The database was divided into training and validation sets. Machine Learning (ML) algorithms were developed with 10-fold cross-validation, and diagnostic accuracy was evaluated.…”
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Correlation Between Depression-Associated Genes and Cancer Types: Predicting Cancer Based on Mutation Frequencies
Published 2025-01-01“…The analysis employed advanced methodologies, including HJ biplot K-means and DBSCAN clustering algorithms for pattern grouping in 2D. This process generated a dataset, enabling the training and testing of machine learning and deep learning classification models. …”
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FGFR2 identified as a NETs-associated biomarker and therapeutic target in diabetic foot ulcers
Published 2025-08-01“…These DEGs were intersected with a NETs-related gene set to identify NETs-associated DEGs (NETDEGs). LASSO logistic regression and Random Forest algorithms were applied to the NETDEGs to select key feature genes. …”
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A Semi-Supervised Machine Learning Approach Using K-Means Algorithm to Prevent Burst Header Packet Flooding Attack in Optical Burst Switching Network
Published 2019-09-01“…In this study, we propose a semi-supervised machine learning approach using k-means algorithm, to detect malicious nodes in an OBS network. …”
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