Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol by David A McAllister, Frances S Mair, Peter Hanlon, Isabella Fauré, Neave Corcoran, Elaine Butterly, Jim Lewsey

“…Clinical and methodological heterogeneity will be assessed, and a random effects meta-analysis performed if appropriate. Otherwise, a narrative synthesis will be performed.Ethics and dissemination This manuscript describes the protocol for a systematic review of observational studies and does not require ethical approval.PROSPERO registration number CRD42020163109.…”
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Age as the Impact on Mortality Rate in Trauma Patients by Onchuda Wongweerakit, Osaree Akaraborworn, Burapat Sangthong, Komet Thongkhao

“…Globally, the fastest-growing population is that of older adults. Geriatric trauma patients pose a unique challenge to trauma teams because the aging process reduces their physiologic reserve. …”
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Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young by Lilya U. Dzhemileva, Elena N. Zakharova, Anna O. Goncharenko, Maria V. Vorontsova, S. A. Rumyantsev, Natalia G. Mokrysheva, Marina Y. Loguinova, Vladimir P. Chekhonin

“…It is of great importance to accurately diagnose MODY, as this allows for the most appropriate treatment of patients and facilitates early diagnosis for them and their families. …”
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CASE REPORT ON TWO CONSECUTIVE PATIENTS WITH NEUROINVASIVE WEST NILE VIRUS INFECTION IN AN INTENSIVE CARE UNIT by Silviya Stoyanova, Raynichka Mihaylova-Garnizova, Emilia Naseva, Severina Dakova, Iva Christova, Konstantin Ramshev

“…Neuroinvasive WNV infection can cause substantial morbidity, particularly among older adults, and high mortality, in the presence of comorbidities. …”
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Use of smartphones for detecting diabetic retinopathy: a protocol for a scoping review of diagnostic test accuracy studies by Helen Smith, Lorainne Tudor Car, Choon Han Tan, Willie-Henri Quah, Colin S H Tan

“…Introduction Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and the leading cause of impaired vision in adults worldwide. Early detection and treatment for DR could improve patient outcomes. …”
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Vancomycin administration and AUC/MIC in patients with acute kidney injury on hemodialysis (HD): randomized clinical trial by Welder Zamoner, Ricardo de Souza Cavalcante, André Luis Balbi, Daniela Ponce

“…Randomized, non-blind clinical trial, including critically ill adults with septic AKI on conventional (4 h) and prolonged HD (6 and 10 h) and using vancomycin for at least 72 h. …”
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Integrated care for older people based on information and communication technology: a scoping review protocol by Yan Zhang, Shanshan Wang, Yutong Tian, Qingyun Cheng, Lixue Meng

“…We propose to recruit older people and integrated care service providers in rural primary healthcare centres and use a structured process of concept mapping to consult and discuss the results of our scoping review to construct an integrated care model and service pathway for older adults that is appropriate to the Chinese social context.…”
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Psychological distress in individuals with irritable bowel syndrome: the roles of body image and self-criticism by Shulamit Geller, Sigal Levy, Ronit Avitsur

“…Thus, the objective of this study was to test the potential mediating roles of these factors in the relationship between IBS and PD.Method: 507 adults participated, including 142 with IBS (Mean age = 31.9, SD = 11.7), and 365 healthy peers (Mean age = 26.2, SD = 6.4), ranging in age from 18 to 75. …”
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Factors affecting nurses retention during the COVID‐19 pandemic: a systematic review by Mansoureh Ashghali Farahani, Shahin Nargesi, Nadia Saniee, Zeinab Dolatshahi, Farshad Heidari Beni, Shabnam Shariatpanahi

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Comparison of modelled diffusion-derived electrical conductivities found using magnetic resonance imaging by Sasha Hakhu, Leland S. Hu, Scott Beeman, Rosalind J. Sadleir

“…This study investigates the variability in conductivity predictions across different microstructure models and evaluates their alignment with experimental observations.MethodsWe used publicly available diffusion databases from neurotypical adults to extract microstructure parameters for three diffusion-based brain models: Neurite Orientation Dispersion and Density Imaging (NODDI), Soma and Neurite Density Imaging (SANDI), and Spherical Mean technique (SMT) conductivity predictions were calculated for gray matter (GM) and white matter (WM) tissues using each model. …”
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Secondary Prevention Using Cholesterol-Lowering Medications in Patients with Prior Atherosclerotic Cardiovascular Disease Events: A Retrospective Cohort Analysis by Xue Han, Steven Fox, Michelle Chu, Jeff McCombs

“…Current guidelines codify recommendations for implementing secondary prevention in appropriate patients. However, in real-world practice, secondary prevention is frequently initiated only after the patient experiences a cardiovascular-related hospitalization. …”
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Ewing Sarcoma of Left Thigh With Nodal, Paraspinal and Soft Tissue Metastatic Lesions: A Case Report by Radeyah Waseem, Muskan Seher, Sohiba Ghazal, Edrees Khan, Hussain Haider Shah, Muhammad Sheheryar Hussain

“…Ewing sarcoma usually affects children and young adults under 20. Usually presenting as a painful swelling and discomfort worsening over time. …”
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Medication safety with oral antitumour therapeutics in paediatrics (youngAMBORA): A mixed-methods approach towards a tailored care program. by Phyllis Lensker, Lisa Cuba, Katja Gessner, Martin F Fromm, Frank Dörje, Markus Metzler

“…The randomised AMBORA trial (Medication Safety With Oral Antitumour Drugs) demonstrated highly positive outcomes of a clinical pharmacological/pharmaceutical care program for adults treated with numerous OAT, but comparable concepts in paediatrics are lacking so far.…”
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Perspectives of Healthcare Professionals and People with a Spinal Cord Injury on Resistance Exercise Intensity in Japan, Indonesia, Korea and Thailand by Kyung Su Jung, Chayaporn Chotiyarnwong, Martha Kurnia Kusumawardani, Seung-Hyun Yoon, Pojchong Chotiyarnwong, Inggar Narasinta, Damayanti Tinduh, Ken Kouda, Fumihiro Tajima

“…Also, it verifies the appropriateness of the conventional indicators for resistance exercise intensity in an Asian context. (2) Methods: 121 certified HCPs and 107 adults with SCI participated in a survey conducted in Indonesian, Japanese, Korean and Thai languages. …”
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Rapid antibiotic susceptibility testing for urinary tract infections in secondary care in England: a cost-effectiveness analysis by Julie V Robotham, Ross D Booton, Stephanie Evans, Nichola R Naylor, Diane Pople, Emily Agnew, Lucy J Bock, J Mark Sutton

“…Objectives To perform a model-based cost-effectiveness evaluation of a rapid antimicrobial susceptibility test.Design A Markov model of a cohort of hospital inpatients with urinary tract infection (with inpatient numbers based on national administrative data from 1 April 2017 to 31 March 2019).Setting Urinary tract infections (UTI) in acute National Health Service (NHS) Trusts in England, from the perspective of the NHS Healthcare system, at a national level.Participants A simulated cohort of approximately 280 000 non-pregnant adult inpatients within secondary care with a clinical suspicion of UTI.Interventions Evaluation of the implementation of a fast bacterial impedance cytometry test (BICT) compared with current practice.Primary and secondary outcome measures Incremental cost, quality-adjusted life years, net monetary benefit, and bed days and appropriateness of antibiotic use per patient. …”
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Evaluation of prescribing practices and treatment failure for purulent skin and soft tissue infections in patients with obesity by Mackenzie L. Miller, Destiny M. Hughson, Noah D. Blower, Andrew P. Jameson, Lisa E. Dumkow

“…Setting: Emergency departments, primary care, and urgent care sites throughout Michigan. Patients: Adult patients with a body mass index of ≥ 30 kg/m2 who received ≥ 5 days of oral antibiotics for purulent cellulitis were included. …”
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‘Blue-lighting’ seizure-related needs in care homes: a retrospective analysis of ambulance call-outs for seizures in North West England (2014–2021), their management and costs, wit... by Adam J Noble, Anthony Guy Marson, Steven Lane, Steve Bell, Pete Dixon, Peter Lloyd, Beth Morris, Tom Shillito

“…Objectives With a projected rise in care home residency and the disproportionate impact of epilepsy and seizures on older adults, understanding seizure-related needs in this population is crucial. …”
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Diagnosing Adolescent Substance Use and Co‐Occurring Disorders Using the Global Appraisal of Individual Needs Quick Version‐4 by Justine W. Welsh, Rebecca M. Durham, Siara I. Sitar, Kathryn C. Modisette, Barbara D. Estrada, Michael L. Dennis

“…The GAIN‐I was administered to adolescents aged 12–17 and adults across levels of care and service settings from 2002 to 2018. …”
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Using the Functional Object Detection—Advanced Driving Simulator Scenario to Examine Task Combinations and Age-Based Performance Differences: A Case Study by Johnell O. Brooks, Rakesh Gangadharaiah, Elenah B. Rosopa, Rebecca Pool, Casey Jenkins, Patrick J. Rosopa, Lauren Mims, Breno Schwambach, Ken Melnrick

“…Study 1 explored older adults’ performance using four possible combinations of FOD—Advanced. …”
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Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review by Steven Shen, Jamie Findlow, Paula Peyrani

“…Polysaccharide conjugate vaccines induce T-cell-dependent immune responses, are immunogenic in infants and adults, and reduce carriage, and vaccination of age groups associated with high-carriage can provide indirect protection in the unvaccinated (herd immunity). …”
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