A key technology for synergistic backfilling of coal-based solid waste and high-salinity wastewater by Shuning DONG, Shujiang YU, Xingling DONG, Buqin ZHANG, Xiaoming GUO, Xiaodong WANG, Kai WANG, Shibin ZHU, Boqiang WU, Lei LIU

“…Methods This study developed a technology for the synergistic treatment of coal-based solid waste and high-salinity wastewater (also referred to as solid-liquid synergistic waste backfilling). …”
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Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice by Nan Dong, Zhenli Xie, Anqi Wei, Yuxin Yang, Yongning Deng, Xu Cheng, Bianbian Wang, Yang Chen, Yuhao Gu, Jingyu Yao, Yuhao Qin, Chaowen Zheng, Xi Zhang, Yuqing Zhang, Xinjiang Kang, Guoqing Chen, Qiumin Qu, Changhe Wang, Huadong Xu

“…Therefore, this work not only elucidate a compensatory mechanism that accounts for the absence of overt PD phenotypes in parkin KO mice, but also contribute to the comprehensive understanding of the progression of PD, opening new avenues for the therapeutic treatment of PD.…”
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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

“…Meta-regression, subgroup and sensitivity analyses were also performed. The odds ratio with a 95% confidence interval was used to assess the association of gender with the viral load suppression rate in patients on third-line antiretroviral therapy. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…CCL21 and CCR7 expressions were spatially associated with brain regional vulnerability to synucleinopathies, as well as with the expression of microglial activation, neuroinflammation, and degeneration-related genes. Also, in mouse models of PD, we showed that CCL21 was overexpressed in DANs in vivo and in vitro. …”
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A Comprehensive Study of Type I (Thermonuclear) Bursts in the New Transient SRGA J144459.2–604207 by Tao Fu, Zhaosheng Li, Yuanyue Pan, Long Ji, Yupeng Chen, Lucien Kuiper, Duncan K. Galloway, Maurizio Falanga, Renxin Xu, Xiaobo Li, Mingyu Ge, L. M. Song, Shu Zhang, Shuang-Nan Zhang

“…We detected 60 type I X-ray bursts in the Insight-HXMT medium energy (ME) data, and 37 were also detected with the low-energy (LE) telescope. …”
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Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…The herb/food-drug interactions also present opportunities for discovery of new functional excipients for enhancing the permeability of poorly absorbed orally administered drugs that are substrates of P-gp and CYP3A4.…”
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Most prevalent jobs of young master’s degree graduates by detailed field of study by Marc Frenette, Tomasz Handler

“…Beyond the monetary gains, the satisfaction derived from one’s day-to-day work activities may also matter in overall life satisfaction. To inform this issue, recent articles have examined the detailed occupations held by graduates of specific disciplines among bachelor’s degree graduates (Frenette and Handler, 2023) and among college or CEGEP certificate or diploma graduates (Frenette and Handler, 2024). …”
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Relaciones entre el recuento de células somáticas, test de mastitis California, conductividad eléctrica y el diagnóstico de mastitis subclínicas en cabras lecheras by V.H. SUAREZ, G.M. MARTINEZ, V. GIANRE, L. CALVINHO, A. RACHOSKI, M. CHAVEZ, A. SALATIN, S. OROZCO, V. SANCHEZ, E. BERTONI

“…El estudio muestra que tanto el CCS (línea de corte <1000000) como el CMT (0, T, 1) pueden ser usados para monitorear la presencia de mastitis subclínicas, teniendo en cuenta que presentan una E buena y alto VP negativo (98%) para el diagnóstico de ubres sanas y una S aceptable para detectar infecciones (especialmente patógenos mayores), siempre que se tengan en cuenta el diagnóstico bacteriológico, la recurrencia de los diagnósticos y otros factores no infecciosos ligados al aumento del CCS en las cabras.…”
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The Role of Open and Distance Learning (ODL) in Promoting Access to Women's Education in Northwestern Nigeria: A Case Study of the National Open University of Nigeria (NOUN) by Shehu Usman Adamu, Bala Kwata Waziri, Adewale Adesina, Babangida Iro

“… A survey was conducted using the National Open University database to ascertain the number of women from the northwestern states of Jigawa, Kaduna, Kano, Katsina, Kebbi, Sokoto and Zamfara studying in the University based on the admission records from 2018 to 2022. The study also checked the faculties where those women registered during the last 4 years to determine the role of Open and Distance Learning in giving women access to higher education. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Area under receiver operating characteristic curve (AUC), accuracy (ACC), and F1-score were calculated to assess the ability of the model to predict each receptor. For comparison we also developed original ResNet-18 without attention module and VGG-19 with and without attention module. …”
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A Candidate High-velocity Exoplanet System in the Galactic Bulge by Sean K. Terry, Jean-Philippe Beaulieu, David P. Bennett, Aparna Bhattacharya, Jon Hulberg, Macy J. Huston, Naoki Koshimoto, Joshua W. Blackman, Ian A. Bond, Andrew A. Cole, Jessica R. Lu, Clément Ranc, Natalia E. Rektsini, Aikaterini Vandorou

“…We conclude this event consists of the highest-velocity exoplanet system detected to date, and also the lowest-mass microlensing host star with a confirmed mass measurement. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…This approach can not only fill the gap in traditional risk assessment but also provide new ideas for the early identification and intervention of CVD. …”
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Evolution, Characteristics and Inspirations of Management Zoning for National Parks in the United States by Zhenwei ZHANG, Hanyue XIAO, Yankang MAO

“…Besides the definition of the zoning system, it is suggested to study and formulate a more macroscopic and comprehensive policy on national park management, which should be similar to the “NPS Management Policy” of the United States, and can not only powerfully support the zoning system but also correctly position the zoning system.…”
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Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

“…As CHON compounds are abundant in both TSB (85 %) and SDB (78 %), CHON compounds also constituted over 50 % of the identified exometabolite formulas. …”
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Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…We will conduct semi-structured in-depth interviews with family medicine residents and early-career PCPs and analyse survey data collected by the College of Family Physicians of Canada. We will also analyse linked administrative health data within each province. …”
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Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…Western blot findings also indicate that NEO inhibits the phosphorylation of ERK, P38, JNK, and P65 but does not reverse the degradation of IκB-α. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…The current drive towards patient blood management in sub-Saharan Africa (SSA)prescribes that we regulate not only the use of blood transfusion but also the management of patients in whom the cause of iron loss or inadequate iron absorption is sought. …”
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The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E by M. Sanni Ali, Lisa Stockdale, Issaka Sagara, Issaka Zongo, Rakiswendé Serge Yerbanga, Almahamoudou Mahamar, Frédéric Nikièma, Amadou Tapily, Frédéric Sompougdou, Modibo Diarra, Duncan Bellamy, Samuel Provstgaard-Morys, Charles Zoungrana, Djibrilla Issiaka, Alassane Haro, Koualy Sanogo, Abdoul Aziz Sienou, Mahamadou Kaya, Seydou Traore, Oumar M. Dicko, Youssouf Kone, Hama Yalcouye, Ismaila Thera, Kalifa Diarra, Paul Snell, Opokua Ofori-Anyinam, Chris Ockenhouse, Cynthia Lee, Katie Ewer, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouedraogo, Alassane Dicko, Daniel Chandramohan, Brian Greenwood

“…The anti-CSP antibody titre falls rapidly after primary vaccination, associated with a decline in efficacy, but the antibody titre and the protective response can be partially restored by a booster dose of vaccine, but this response is also transitory. In many malaria- endemic areas of Africa, children are at risk of malaria, including severe malaria, until they are five years of age or older and to sustain protection from malaria for this period by vaccination with RTS,S/AS01E, repeated booster doses of vaccine may be required. …”
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Pregnancy after kidney and liver transplantation by A Wise, N E Diana, B Bobat, R T Saggers, S Bhoora, S Budhram, L Chauke, V G Lala, A Mahomed, D Mokgoko, M Seabi, B Moore, S Naidoo, R B Nyakoe, N Odell, G Paget, L Wium, J Zamparini

“…By addressing the complexities of managing pregnant women with kidney or liver transplants, this article underscores the importance of tailored care and the involvement of various medical specialists. It also explores the safety of and potential complications associated with specific immunosuppressive therapies during pregnancy. …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…Molecular modelling studies also revealed that ARIP binds β-arrestins as does V2Rpp, the phosphorylated peptide derived from V2R, and that replacing the p-Ser and p-Thr residues of V2Rpp with Glu residues does not alter ARIP’s inhibitory activity on β-arrestin recruitment. …”
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