Phase I trial on the safety of olprinone for low central venous pressure management aimed at haemorrhage control during open and laparoscopic hepatectomy: a study protocol by Katsuhiko Uesaka, Yuya Miura, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Yoshiyasu Kato, Takuya Oyakawa, Eiji Ando, Sunao Tamai

“…The trial employs a 3+3 cohort study design to determine the maximum tolerated dose (MTD) and identify dose-limiting toxicities. The study also assesses the trends in CVP and circulatory dynamics using the FloTrac System, alongside safety evaluations. …”
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Cost of Serum Versus Skin Allergy Testing Among Medicare Fee-for-Service Beneficiaries in the United States by Kenny Y. Kwong, Yang Z. Lu

“…Cost of testing per beneficiary was also lower in sIgE testing only compared with skin prick tests only ($161 vs $247). …”
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Discordance between 90Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass micro... by Thomas Carlier, Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Niklaus Schaefer, Maria del Sol Pérez Lago, Clément Bailly, Yuni K. Dewaraja, Thiago V. M. Lima

“…The objective of this work was to investigate whether these discrepancies were also seen in patients. Methods We analysed patient 90Y-PET reconstructions (99 glass and 15 resin microspheres) from 4 different institutions and 4 different systems. …”
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A longitudinal study of the association between the outcome of bariatric surgery and mental health indicators in Chinese patients: an examination of the interaction effect by Hung-Yen Lin, Te-Chang Changchien, Tsung-Jen Hsieh, Cheng-Sheng Chen, Yung-Chieh Yen

“…Besides the physical burden, obesity is also associated with mental health issues. The mutual relationship between mental health issue and surgical outcome remains unclear, particularly in the population of ethnic Chinese patients. …”
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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis by Li Q, Li D, Tian C, Liu X, Wang H, Liu H

“…The therapeutic effect of Baji capsule was evaluated by high-resolution micro-computed tomography (Micro-CT) and tissue section staining, serum inflammatory factor levels were assessed by ELISA, serum oxidative stress-related marker levels were determined by kits, and finally the mechanism was explored by network pharmacology and then verified by immunohistochemistry.Results: Micro-CT results showed that Baji capsule attenuated LPS-induced inflammatory bone loss.Baji capsule also reduced serum inflammatory factor levels and oxygen free radical production. …”
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Unlocking the link: predicting cardiovascular disease risk with a focus on airflow obstruction using machine learning by Xiyu Cao, Jianli Ma, Xiaoyi He, Yufei Liu, Yang Yang, Yaqi Wang, Chuantao Zhang

“…For the subpopulation with airflow obstruction, the XGBoost model was also selected as the optimal model for predicting CVD risk (AUC = 0.6645, AP = 0.3545). …”
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Sequencing whole genomes of the West Javanese population in Indonesia reveals novel variants and improves imputation accuracy by Edwin Ardiansyah, Anca-Lelia Riza, Sofiati Dian, Sofiati Dian, Ahmad Rizal Ganiem, Ahmad Rizal Ganiem, Bachti Alisjahbana, Bachti Alisjahbana, Todia P. Setiabudiawan, Arjan van Laarhoven, Reinout van Crevel, Vinod Kumar, Vinod Kumar

“…This created three reference panels: EAS 1KGP3 (EASp), Indonesian (INDp), and a combined panel (EASp + INDp). We also used ten West-Javanese samples with WGS and SNP-typing data for benchmarking. …”
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Integrative evidence reveals a new species of Hysterothylacium (Nematoda: Ascaridoidea), with the characterization of its complete mitochondrial genome by Hui-Xia Chen, Hai-Xia Qiao, Wen-Ting Zhao, Xiao-Hong Gu, Liang Li

“…The complete mitochondrial genome of the new species was sequenced and annotated, which represents the first mitogenomic data for the genus Hysterothylacium, and also for the family Raphidascarididae. The mitogenome of H. hainanense sp. n. is 14059 bp in length, including 12 protein coding genes (missing atp8), 22 tRNA genes, 2 rRNA genes and 2 non-coding regions, which has 67.0% of overall A + T content, and represents the lowest level of A + T content in the ascaridoid mitogenomes reported so far. …”
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High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…High-intensity statin also had obvious effects on lowering the LDL-C level but no clear effects on renal protection. …”
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Higher systemic immune-inflammation index is associated with increased risk of Parkinson’s disease in adults: a nationwide population-based study by Jiayu Zhao, Zhipeng Wu, Zhipeng Wu, Fengyin Cai, Xuejv Yu, Zhenyu Song

“…After excluding individuals with any missing values, sensitivity analysis also found a positive association between SII and PD. …”
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Spin-down of Solar-mass Protostars in Magnetospheric Accretion Paradigm by Shinsuke Takasao, Masanobu Kunitomo, Takeru K. Suzuki, Kazunari Iwasaki, Kengo Tomida

“…As magnetospheric accretion is expected to occur in other accreting objects such as protogiant planets, this study will also contribute to the understanding of the angular momentum of such objects.…”
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Characterization and DNA barcoding of Zambian plant species used as inoculum in the traditional fermentation of Munkoyo; a cereal-based beverage by Mubonda Kalumbilo, David Chuba, Agripina Banda, Eddy J. Smid, Sijmen E. Schoustra, Gerlinde B. De Deyn

“…Conclusions This study identified three common Munkoyo plant species and demonstrated ITS2 as a robust DNA barcode for their identification. It also established the influence of soil texture on the distribution of these plants, contributing to the understanding of Munkoyo production’s biological and environmental determinants.…”
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Correlation of macronutrient and micronutrient intake with anemia status in pulmonary tuberculosis patients at namorambe community health center by Aritonang Evawany Yunita, Manalu Sarah Patumona, Manalu Samuel MH

“…Cure of TB disease is also supported by the health status of TB patients which cannot be separated from nutritional status which is influenced by food consumption, both macro and nutritional nutrients. micronutrients. …”
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Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis by Ipek Pervaz, Lilly Thurn, Cecilia Vezzani, Luisa Kaluza, Anne Kühnel, Nils B. Kroemer

“…These findings underscore the relevance of taVNS protocols in optimizing its use for specific applications that may require modulation of tonic vs. phasic monoaminergic responses and might also help to gain mechanistic insights into potential therapeutic effects.…”
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Predictors of COVID-19 vaccine hesitancy among biomedical students of Rivers State University by Moore Ikechi Mike-Ogburia, Gift Mibilanyeofori Hart, Barynem Vito-Peter, Aisha Dio, Victory Chidinma Nwogu

“…Additionally, the perception that COVID-19 vaccines will always have adverse effects was also a significant predictor (RR = 1.110, 95% CI: 1.019–1.253, p = 0.0204). …”
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Pendekatan Model ADDIE dan Framework MDA pada Gamifikasi Edukasi Pendidikan Seks Anak Usia Dini by Cynthia Hayat, Stefani Cancerita

“…This game application has also been tested on 45 users by using the ideal score (criteria) which is used to calculate the rating scale or interval score and the total number of answers. …”
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Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis by Sanne A E Peters, Mark Woodward, Paul Mitchell, Rachel R Huxley, Gemma Taylor, Linda M O’Keeffe

“…Individual participant data from three sources were also available to supplement analyses of published literature.Eligibility criteria for selecting studies Cohort studies reporting the sex-specific relative risk (RR) of lung cancer associated with smoking.Results Data from 29 studies representing 99 cohort studies, 7 million individuals and >50 000 incident lung cancer cases were included. …”
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Does a Provider Contact Wristband Reduce Emergency Department Visit Rates Following Hip or Knee Arthroplasty? by David C. Hein, MD, Ajay K. Srivastava, MD, Seann E. Willson, MD, Paul M. Telehowski, MD, Patrick J. Atkinson, PhD, Theresa S. Atkinson, PhD

“…Residents who responded to calls and call logs were also reviewed. Results: At 2 years after implementation, a total of 1023 joint replacements produced 273 calls or 1 call per 3.75 patients. …”
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The demographic history of the wild crop relative Brachypodium distachyon is shaped by distinct past and present ecological niches by Minadakis, Nikolaos, Williams, Hefin, Horvath, Robert, Caković, Danka, Stritt, Christoph, Thieme, Michael, Bourgeois, Yann, Roulin, Anne C.

“…Grasses encompass more than 10,000 species and cover more than 40% of the world land area from tropical to temperate regions. Given that grasses also supply about a fifth of the world's dietary protein as cereal grains, unlocking the sources of phenotypic variation in B. distachyon is hence of prime interest in fundamental and applied research in agronomy, ecology and evolution. …”
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ALGORITHMIC THINKING IN HIGHER EDUCATION: DETERMINING OBSERVABLE AND MEASURABLE CONTENT by Marian Byrka, Andrii Sushchenko, Volodymyr Luchko, Galina Perun, Victoria Luchko

“…The design of the ATCS is also based on algorithmic thinking as a complex phenomenon that integrates five types of thinking: abstract, logical, figurative, conceptual, and constructive. …”
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