From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…Current obstacles and future directions regarding the bench-to-bedside transition are also discussed.…”
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Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Mechanistically, COL17A1 interacted with ACTN4 protein, and the anticancer effects mediated by COL17A1-decreased CAFs in resistant PC cells were reversed by ACTN4 overexpression. In vivo assay also showed that COL17A1-decreased CAFs suppressed the growth and GEM resistance in PC by ACTN4. …”
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Klasifikasi Mutu Telur Burung Puyuh Berdasarkan Warna dan Tekstur Menggunakan Metode K-Nearest Neighbor (KNN) dan Fusi Informasi by Arwin Datumaya Wahyudi Sumari, Putri Indah Mawarni, Arie Rachmad Syulistyo

“…In addition, the classification with information fusion was able to outperform the classification without information fusion by 11.11% at the same  value of 7 and information fusion is also able to accelerate classification process by 0.22 seconds compared to that of without information fusion. …”
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Ethics and end-of-life in pediatric and neonatal ICUs: a systematic review of recommendations by Diana Špoljar, Sunčana Janković, Dina Vrkić, Geraldine McNamara, Marko Ćurković, Milivoj Novak, Boris Filipović-Grčić, Stefan Grosek, Chris Gastmans, Bert Gordijn, Ana Borovečki

“…The international, national, or institutional papers providing expert guidelines and recommendations comprehensively addressing either withholding/withdrawing of life sustaining treatment, palliative care, and/or intentional life terminating actions in NICUs and PICUs were included in analysis. Also, only papers published in English language were considered. …”
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Establishing primary care physician commitment in Canadian long-term care homes: a protocol for a modified e-Delphi study by Andrew P Costa, Aaron Jones, Darly Dash, Paula Rochon, Patrick Quail, Rachel D Savage, Henry Yu-Hin Siu, Lisa M McCarthy, Nathan Stall, Dee Tripp, Maya Potter, Paul Katz, Samantha Peck

“…The first round evaluates the relevance and feasibility of candidate statements through an online questionnaire. Panellists may also write open-ended, qualitative responses to add rationales, suggest alternatives and share new ideas. …”
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Report on the Academic Symposium: Youth Quotas − The Answer to Changes in Age Demographics? by Igor Dimitrijoski

“…Some key questions to be addressed at the symposium were: Should youth quotas be limited to the political arena (political parties, parliaments, etc.) or should they also be implemented in other fields (economic activity, companies, associations, organisations, etc.)? …”
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Prevalence, risk factors, and prognostic implications of intraoperative bleeding during CF-LVAD implant by Ibrahim Mortada, MD, Christos Kourek, MD, PhD, Rupesh Kshetri, MD, Arun Singhal, MD, Anthony Panos, MD, Alexandros Briasoulis, MD, PhD, Mohammed Mhanna, MD, MPH, Shareef Mansour, MD, Kristine Yumul, MD, Paulino Alvarez, MD, Ernesto Ruiz Duque, MD

“…Intraoperative bleeding is also correlated with worse clinical outcomes, higher 90-day mortality (hazard ratio [HR] 10.4, p < 0.01, CI 95% 3.28-33.38) 206 subjects with 14 failures. …”
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Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses by Giorgio Ivan Russo, Maria Giovanna Asmundo, Andrea Cocci, Ali Saber Abdelhameed, Annalisa Liprino, Filippo Giacone, Debora Lombardo, Antonino Guglielmino, Sandrine Chamayou

“…Interestingly, we found a significant trend decrease of motility (A+B) (28.0% vs. 21.0%; p&lt;0.01) and pH (8.1 vs. 7.9; p&lt;0.01) In patients affected by asthenospermia, motility (A+B) dropped significantly from day 1 to day 7 (11.8% vs. 6.1%; p&lt;0.01) and also in patients with teratospermia morphology dropped significantly (2.13% vs. 1.26%; p&lt;0.01).ConclusionThe findings support the use of tailored abstinence guidelines to optimize semen quality based on patient-specific semen profiles, with normospermic men benefiting from longer abstinence durations to increase concentrations, while patients with motility or morphology impairments, may benefit from shorter abstinence periods to mitigate sperm quality declines.…”
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The impact on productivity costs of reducing unemployment in patients with advanced breast cancer: A model estimation based on a Portuguese nationwide observational study by Leonor Vasconcelos de Matos, Margarida Borges, Ana Teresa Oliveira, Carolina Bulhosa, Luís Silva Miguel, Tiago Fidalgo de Freitas, Renato Cunha, Ana Duarte Mendes, Ana Júlia Arede, Cristiana Marques, Diogo Alpuim Costa, Jorge Alves Correia, Margarida Brito, Mário Fontes e Sousa, Teresa Guimarães, Fatima Cardoso

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Scopoletin as a cardioprotective agent against cisplatin-induced oxidative stress and inflammation by Esam Qnais, Omar Gammoh, Yousra Bsieso, Mohammad Alqudah, Mohammad Wedyan, Sara Altaber, Alaa A.A. Aljabali, Abdelrahim Alqudah, Taher Hatahet

“…The efficacy of scopoletin in modulating the p62/Keap1/Nrf2 pathway was also examined. Results: Histopathological assessments showed less tissue damage in scopoletin-treated groups (p < 0.01). …”
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Effect of 25-hydroxycholecalciferol and high phytase doses on performance, vitamin D status, bone mineralization, and mechanistic target of rapamycin gene expression of broilers by L.S. Bassi, C.C.S. Martins, C.A. Lozano-Poveda, I.C. Dias, S.G. Oliveira, A. Maiorka

“…Phytase did not affect growth performance from 1 to 21 d, but a higher dose (2 000 FYT/kg) reduced feed intake and FCR from 22 to 42 d compared to 600 FYT/kg, also reducing FCR in the total period (P < 0.05). …”
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Caracterización acústica de fincas bajo pago por servicios ambientales en la Reserva Forestal Golfo Dulce, Costa Rica by Jimmy Barrantes-Madrigal, Mónica Retamosa, Ricardo Bedoya-Arrieta, Adriana Valerio-Madrigal, Jonathan Sánchez-Alpízar

“…[Resultados]: Se encuentra que los sitios más fragmentados presentaron mayor actividad, energía y diversidad acústica, posiblemente por efectos de borde y ecotonos presentes, así como un alto componente de bosque en la matriz circundante. …”
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Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…Mean net diameter change (resting to maximum) also differed significantly (p = 0.0365) between WT (19.11 μm) and Tg mice (11.13 μm). …”
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Danggui-Shaoyao-San Can Ameliorate Alzheimer&rsquo;s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology by Zhang KX, Zhang JW, Jiang YH, Wang YR, Liu ZL, Ding PL, Wang XY, Cui WQ, Xu XQ, Wang YH

“…Kai-Xin Zhang,1 Ji-Wei Zhang,2 Yan-Hong Jiang,1 Yi-Ran Wang,1 Zhen-Ling Liu,1 Peng-Li Ding,1 Xiang-Ying Wang,1 Wen-Qiang Cui,3 Xiang-Qing Xu,3,&ast; Ya-Han Wang3,&ast; 1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 2College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 3Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiang-Qing Xu, Ya-Han Wang; Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China, Email happyxiangqing@163.com; sdwangyahan@sina.comBackground: Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine prescription with a history of nearly 2000 years, originally widely used for gynecological diseases, and in recent years research has found that DSS also has a good therapeutic effect on Alzheimer’s disease (AD).Purpose: The objective is to investigate the metabolic components of the DSS in the blood and the potential mechanisms for AD.Materials and Methods: Liquid chromatography‒mass spectrometry (LC-MS) combined with gas chromatography‒mass spectrometry (GC-MS) based non-targeted metabolomics were used to conduct in-depth research. …”
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Analisis Pengaruh Kualitas Layanan Terhadap Kepuasan Pelanggan dan Loyalitas Pengguna Aplikasi Jenius Menggunakan Model E-S- Qual dan E- Recs- QUal (Studi Kasus: Pengguna Aplikasi... by Alfansya Achmad Mulyadi, Satrio Hadi Wijoyo, Hanifah Muslimah Az-Zahra

“…Namun, aplikasi Jenius masih ditemui permasalahan terkait keluhan-keluhan terkait layanan yang diberikan terlihat pada ulasan aplikasi Jenius di Appstore dan customer service Jenius di social media twitter. Hal ini menjadi alasan dilakukannya penelitian untuk mengetahui aspek dari kualitas layanan yang mempengaruhi kepuasan dengan loyalitas pengguna aplikasi Jenius, khususnya di Kota Malang yang saat ini sedang berkembang di bidang digital finance. …”
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MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing by Robinson Vidva, Mir Abbas Raza, Jaswant Prabhakaran, Ayesha Sheikh, Alaina Sharp, Hayden Ott, Amelia Moore, Christopher Fleisher, Hailey Netherton, Evan Goldstein, Pothitos M. Pitychoutis, Tam V. Nguyen, Aaron Sathyanesan

“…Currently available open-source alternatives are difficult to implement and deploy. These solutions also do not have the capability to track ambient variables that affect colony well-being. …”
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Affective touch enhances low gamma activity during hand proprioceptive perception in children with different neurodevelopmental conditions by Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, José Antonio Mingorance, José Antonio Mingorance, José Antonio Mingorance, Francesc Mestre-Sansó, Vicent Canals, Yannick Bleyenheuft, Pedro Montoya, Pedro Montoya, Inmaculada Riquelme, Inmaculada Riquelme, Inmaculada Riquelme

“…Proprioception and pleasantness of affective and non-affective touch were also assessed.ResultsAffective touch increased proprioceptive gamma power density. …”
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Bony ankylosis adversely affects postoperative hip function in patients with ankylosing spondylitis undergoing total hip arthroplasty: a retrospective cohort study of 319 consecuti... by Liangliang Li, Jun Fu, Chi Xu, Ming Ni, Wei Chai, Libo Hao, Yonggang Zhou, Jiying Chen

“…The bony ankylosis group also had lower postoperative HHS (89 ± 5 vs. 92 ± 5) and had significantly higher WOMAC scores (43 ± 20 vs. 31 ± 18) than the hip stiffness group (P < 0.001). …”
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Unveiling Hidden Aspects of Intermediary Organizations in Innovation: A Systematic Review through the Lens of Industry Taxonomy by Mostafa Mohseni kiasari, ‌Javad Soltanzadeh, Amirhossein Azizi Hasanabadi, Hamed Talebi

“…The current research aimed to provide a comprehensive definition of the current knowledge and the classification of intermediary institutions in industries by Poit (1984) based on the definitional functions of Howells (2006) and also to create an interpretation of the existing research gaps.   …”
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Yngre förskolebarns litteratursamtal by Hanna Thuresson

“…Finally, it emphasizes that children’s multimodal literary discussions not only foster different strategies for reading and storytelling but also create an understanding of various media.  …”
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