Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing by Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Jinzhi Xu, Ningyi Shao, Guokai Chen, Junfeng Zhang, Lei Dong, Chunming Wang

Subjects: “…adoptive cell transfer…”
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A Preliminary Study on the Therapeutic Role of γδT Cells in Triple‐Negative Breast Cancer by Shi Qiu, Qin‐Yu Han, Xian Zhao, Wen‐Jing Li, Xiang‐Qi Li

“…Following 21 days of adoptive transfer via tail vein injection, γδΤ cells at both low and high doses significantly reduced tumor volume and mass compared to the PBS control group (p < 0.001). …”
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Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens by Shannalee Martinez, Vladimir V. Senyukov, Suheyla Hasgur, Arianexys Aquino-López, Peter D. Emanuel, Y. Lucy Liu, Elliot Stieglitz, Gregory Behbehani, Amanda R. Campbell, Dean A. Lee

“…Monoclonal antibodies and adoptive cell transfer of natural killer (NK) cells or T cells are approved or being investigated for other myeloid leukemias; however, their activity against JMML warrants further investigation. …”
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FUNCTIONAL ACTIVITY OF MURINE B CELL: A ROLE OF MICROENVIRONMENT by I. N. Dyakov, I. V. Grigoriev, E. V. Sidorova, I. N. Chernyshova

“…Intraperitoneal transfer of CBA splenocytes also did not induce their accumulation. …”
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Calcium nanoparticles target and activate T cells to enhance anti-tumor function by Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy T. Watford, Gang Zhou, Jin Xie

“…When tested in metastatic tumor models, T cells loaded with the calcium nanoparticles prior to adoptive cell transfer control tumor growth better, resulting in prolonged animal survival. …”
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Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti by David R. Hall, Rebecca M. Johnson, Hyeogsun Kwon, Zannatul Ferdous, S. Viridiana Laredo-Tiscareño, Bradley J. Blitvich, Doug E. Brackney, Ryan C. Smith

“…Here, we provide evidence that dengue virus and Zika virus actively infect Aedes aegypti hemocytes and demonstrate, through phagocyte depletion, that hemocytes facilitate virus infection to peripheral tissues including the ovaries and salivary glands. Adoptive transfer experiments further reveal that virus-infected hemocytes efficiently confer virus infection to naïve recipient mosquitoes. …”
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Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice by Marianthi Gioulbasani, Tarmo Äijö, Siyao Liu, Stephanie A. Montgomery, Nathan D. Montgomery, David Corcoran, Ageliki Tsagaratou

“…In order to gain insight on the TET mediated molecular events that safeguard T cells from aberrant proliferation we performed serial adoptive transfers of murine CD4 T cells that lack concomitantly TET2 and TET3 to fully immunocompetent congenic mice. …”
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IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment by Mario Catarinella, Andrea Monestiroli, Giulia Escobar, Amleto Fiocchi, Ngoc Lan Tran, Roberto Aiolfi, Paolo Marra, Antonio Esposito, Federica Cipriani, Luca Aldrighetti, Matteo Iannacone, Luigi Naldini, Luca G Guidotti, Giovanni Sitia

“…Abstract Colorectal cancer (CRC) metastatic dissemination to the liver is one of the most life‐threatening malignancies in humans and represents the leading cause of CRC‐related mortality. Herein, we adopted a gene transfer strategy into mouse hematopoietic stem/progenitor cells to generate immune‐competent mice in which TEMs—a subset of Tie2+ monocytes/macrophages found at peritumoral sites—express interferon‐alpha (IFNα), a pleiotropic cytokine with anti‐tumor effects. …”
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Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8+ T cells by Zimeng Cai, Mina Kozai, Hironobu Mita, Hiroto Takeuchi, Satoru Mizuno, Kazuhiro Matsuo, Kensuke Takada

“…Although RORα is highly expressed in memory CD8+ T cells, its functional relevance has not been investigated.MethodsPrimary and secondary memory T cells that are sufficient or deficient of RORα were induced by adoptive transfer of naïve OT-I T cells to recipient mice and subsequent infection with Listeria monocytogenes expressing ovalbumin (LM-OVA). …”
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Macrophagic Ym1 orchestrates γδT cell-derived IL-17 production and keratinocyte functionality to mediate psoriasis-like skin inflammation by Wentao Zhang, Fei Li, Yu Wang, Meiyang Fan, Yan Zhao, Yanglong Guan, Yan Zhou, Shemin Lu, Rikard Holmdahl, Liesu Meng, Wenhua Zhu

“…Natural polymorphism of Ym1 influenced the development of skin inflammation, dependent on macrophages, since adoptive transferring of Ym1-deficient macrophages alleviated disease, whereas recombinant Ym1 worsened it. …”
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Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms by Xi-Meng Sun, Ze-Ni Luo, Wei Wang, Chun-Yue Hao, Zhi-Ang Li, Saeed El-Ashram, Xin-Ping Zhu

“…The content of IL-10 in culture supernatant was measured by an enzyme-linked immunosorbent assay (ELISA), and CD4+Foxp3+ Treg cells were sorted and adoptively transferred (40,000 cells/mouse) via tail vein injection into C57BL/6 J mice, followed by DSS administration to induce acute colitis. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Since regulatory T (Treg) cells primarily express the high-affinity IL-2 receptor whereas naïve effector T and natural killer cells mainly express the low-affinity IL-2 receptor, CD25-blocking IL-2cx have traditionally been considered as potential cancer therapeutics, particularly in combination with immune checkpoint inhibitors (ICIs).Methods Stimulation of antigen-primed T cells by IL-2cx in the absence or presence of ICIs was evaluated through adoptive transfer of primed ovalbumin-specific T cells and analysis of expansion. …”
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A recombinant oncolytic Newcastle virus expressing MIP-3α promotes systemic antitumor immunity by Yan Sun, Liming Zhang, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Zhuoxuan Lu, Rong Cao, Guang-Hong Tan

“…Compared with NDV-WT, intratumoral injection of NDV-MIP3α and the adoptive transfer of T lymphocytes from mice injected with NDV-MIP3α resulted in a significant suppression of B16 and CT26 tumor growth. …”
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Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation by Lifang Li, Yuping Han, Xiangrong Xie, Dakun Ren, Ying Zhang, Shaofeng Hao, Xuming Guo

“…Corneal allograft recipients were treated with alum, adoptive transfer of alum-induced MDSCs, or combined transfer of MDSCs and Tregs. …”
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Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis by Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee

“…C57BL/6 mice that underwent adoptive cell transfer of GPx8‐deficient macrophages displayed a similar phenotype of enhanced colitis, indicating a critical role of GPx8 in macrophages. …”
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Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer by Mingshuang Wang, Liwei Pang, Yingjie Sun, Jingjing Han, Jiani Fan, Wenhui Shen, Xiaonan Hu, Bingqian Yang, Haoming Ning, Yanan Kong, Duo Li, Wenshan Zhao, Ranran Shi, Ling Ran, Yuanming Qi, Yahong Wu

“…Notably, adoptive transfer of T cells primed with a peptide pool containing these eight neoepitopes significantly suppressed tumor growth and enhanced CD8+ T cells infiltration within tumor tissue. …”
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A New Mask R-CNN-Based Method for Improved Landslide Detection by Silvia Ullo, Amrita Mohan, Alessandro Sebastianelli, Shaik Ahamed, Basant Kumar, Ramji Dwivedi, Ganesh R. Sinha

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Structural mechanism of proton conduction in otopetrin proton channel by Ninghai Gan, Weizhong Zeng, Yan Han, Qingfeng Chen, Youxing Jiang

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Skin/core fracture toughness of sandwich structures: a comparison of different experimental arrangements by Amal Alliyankal Vijayakumar, Muhammad Zahid, Stefano G. Corvaglia, Alfonso Maffezzoli

“…Nonetheless, skin/core debonding is a critical failure mode, limiting the stress transfer between the skin and core. This research adopts a cost-effective thermoforming approach for simultaneous commingled E-glass/Polypropylene (PP) fabric consolidation and closed-cell PP foam core bonding via a one-stage non-isothermal process. …”
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