Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset by Tianqi Xu, Zhihuai Deng, Yinhui Yu, Wenchao Duan, Zeyu Ma, Haoran Liu, Lianling Li, Moxuan Zhang, Siyu Zhou, Pengda Yang, Xueyan Qin, Zhenyu Zhang, Fangang Meng, Fangang Meng, Fangang Meng, Yuchen Ji

“…FreeSurfer was used to perform vertex-wise comparisons of cortical surface area (CSA) and cortical thickness (CT), whereas the Brain Connectivity Toolbox was implemented to construct and analyze the structural covariance networks.ResultsIn patients with LPD, we found reduced CSA in the right supramarginal gyrus (SMG), right precuneus (PCUN), left inferior parietal lobule (IPL), and left lingual gyrus (LING) compared to RPD, while no significant differences in CT were found between the two groups. …”
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Re-emergence of thiamine deficiency disease in the Pacific islands (2014-15): A case-control study. by Eric J Nilles, Atarota Manaia, Bineta Ruaia, Clare Huppatz, Catherine Ward, Peter George, Christiaan Sies, Alessio Cangiano, James Sejvar, André Reiffer, Teatoa Tira

“…Active and passive surveillance was then conducted to identify additional cases. A questionnaire to identify potential risk factors and blood samples to assay biochemical indices were collected from cases and asymptomatic controls. …”
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Water management mitigates drought stress effects on maize leaf senescence and post-anthesis dry matter accumulation by Zhenhua Yan, Yi Liu, Shang Gao, Hongye Yang, Dayun Feng, Kexin Gao, Bo Ming, Keru Wang, Peng Hou, Shaokun Li, Ruizhi Xie

“…A field experiment was conducted during the 2022–2023 maize growing seasons at two representative sites in China’s Huang-Huai-Hai Plain, implementing three water management strategies: maintaining relative soil water content (RSWC) above 80 % (I80), maintaining RSWC above 60 % (I60), and non-interference (NI) under drought stress. …”
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Multiple loci are associated with white blood cell phenotypes. by Michael A Nalls, David J Couper, Toshiko Tanaka, Frank J A van Rooij, Ming-Huei Chen, Albert V Smith, Daniela Toniolo, Neil A Zakai, Qiong Yang, Andreas Greinacher, Andrew R Wood, Melissa Garcia, Paolo Gasparini, Yongmei Liu, Thomas Lumley, Aaron R Folsom, Alex P Reiner, Christian Gieger, Vasiliki Lagou, Janine F Felix, Henry Völzke, Natalia A Gouskova, Alessandro Biffi, Angela Döring, Uwe Völker, Sean Chong, Kerri L Wiggins, Augusto Rendon, Abbas Dehghan, Matt Moore, Kent Taylor, James G Wilson, Guillaume Lettre, Albert Hofman, Joshua C Bis, Nicola Pirastu, Caroline S Fox, Christa Meisinger, Jennifer Sambrook, Sampath Arepalli, Matthias Nauck, Holger Prokisch, Jonathan Stephens, Nicole L Glazer, L Adrienne Cupples, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Kazuhiko Yamamoto, Naoyuki Kamatani, Michael Stumvoll, Anke Tönjes, Inga Prokopenko, Thomas Illig, Kushang V Patel, Stephen F Garner, Brigitte Kuhnel, Massimo Mangino, Ben A Oostra, Swee Lay Thein, Josef Coresh, H-Erich Wichmann, Stephan Menzel, JingPing Lin, Giorgio Pistis, André G Uitterlinden, Tim D Spector, Alexander Teumer, Gudny Eiriksdottir, Vilmundur Gudnason, Stefania Bandinelli, Timothy M Frayling, Aravinda Chakravarti, Cornelia M van Duijn, David Melzer, Willem H Ouwehand, Daniel Levy, Eric Boerwinkle, Andrew B Singleton, Dena G Hernandez, Dan L Longo, Nicole Soranzo, Jacqueline C M Witteman, Bruce M Psaty, Luigi Ferrucci, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh

“…To investigate functional relationships among variants contributing to variability in the six WBC traits, we utilized gene expression- and pathways-based analyses. We implemented gene-clustering algorithms to evaluate functional connectivity among implicated loci and showed functional relationships across cell types. …”
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Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair by Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer

“…Results Our data show that the addition of 1 mM L-ascorbic acid-2-phosphate (AA) to cultures for one passage during MSC expansion prior to initiation of differentiation improves chondrogenic differentiation. …”
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Harnessing sequencing data for porcine reproductive and respiratory syndrome virus (PRRSV): tracking genetic evolution dynamics and emerging sequences in US swine industry by Srijita Chandra, Guilherme Cezar, Kinath Rupasinghe, Edison Magalhães, Gustavo S. Silva, Marcelo Almeida, Bret Crim, Eric Burrough, Phillip Gauger, Darin Madson, Joseph Thomas, Michael Zeller, Jianqiang Zhang, Rodger Main, Albert Rovira, Mary Thurn, Paulo Lages, Cesar Corzo, Matthew Sturos, Kimberly VanderWaal, Hemant Naikare, Franco Matias-Ferreyra, Rob McGaughey, Jamie Retallick, Sara McReynolds, Sara McReynolds, Jordan Gebhardt, Angela Pillatzki, Jon Greseth, Darren Kersey, Travis Clement, Jane Christopher-Hennings, Beth Thompson, Beth Thompson, Jonah Perkins, Melanie Prarat, Dennis Summers, Craig Bowen, Joseph Boyle, Kenitra Hendrix, James Lyons, Kelli Werling, Andreia G. Arruda, Mark Schwartz, Mark Schwartz, Paul Yeske, Deborah Murray, Brigitte Mason, Peter Schneider, Samuel Copeland, Luc Dufresne, Daniel Boykin, Corrine Fruge, William Hollis, Rebecca Robbins, Thomas Petznick, Kurt Kuecker, Lauren Glowzenski, Megan Niederwerder, Xiaoqiu Huang, Daniel C. L. Linhares, Giovani Trevisan

“…A novel sequence detection system was implemented, categorizing sequences based on similarity thresholds, ambiguities, and length criteria, identifying 167 novel sequences for the period between 2010 and 2024, whereas only three had continued detection in the field over time, forming clusters of detection. …”
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Multisite binding of bacteriophages on lipopolysaccharides in Escherichia coli O157:H7 and the adaptive costs of phage resistance by Yang Wang, Jing Li, Yuhan Zhang, Yao Li, Xinru Chen, Jiaqi Cui, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang

“…To address the challenge of phage-resistant strains, we can adopt two strategies: using phage cocktails targeting multiple bacterial receptors to delay resistance development; and implementing a 'phage shift' treatment strategy that exploits the adaptive trade-offs of phage-resistant bacteria. …”
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Subgrid-scale aerosol–cloud interaction in the atmospheric chemistry model CMA_Meso5.1/CUACE and its impacts on mesoscale meteorology prediction by W. Zhang, H. Wang, X. Zhang, Y. Peng, Z. Liu, D. Wang, D. Zhang, C. Han, Y. Zhao, J. Zhong, W. Jia, H. Ning, H. Che

“…Here, a subgrid-scale ACI mechanism is implemented by explicitly treating cloud microphysics in the KFeta convective scheme with real-time size-resolved hygroscopic aerosol activation and introducing subgrid-scale cloud radiation feedback in an atmospheric chemistry model, CMA_Meso5.1/CUACE. …”
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The current status, trends, and challenges of Alzheimer’s disease and other dementias in Asia (1990–2036) by Ziyang He, Ziyang He, Haoqin Zhang, Haoqin Zhang, Guishan Hu, Yinan Qiao, Can Yin, Jianqiao Li, Hong Lin, Anguo Wu, Dalian Qin, Betty Yuen-Kwan Law, Guangqiang Hu, Lu Yu

“…It is imperative to implement targeted prevention and intervention strategies, enhance chronic disease management, and control risk factors.…”
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UniPhen “PIWI”—high-resolution simulation of the phenological development of 13 fungus-tolerant cultivars based on a broad observation data set from Central Europe by Daniel Molitor, Kristina Heilemann, César Dionisio Jiménez-Rodríguez, Silke Hüther, Oliver Trapp, Anouck Stalport, Julien Louvieaux, Olivier Viret, Martin Ladach, Stefan Schumacher, Bettina Lindner, Pierre-Henri Dubuis, Anne-Lise Fabre, Michael Weber, Arno Schmid, Josef Terleth, Wolfgang Renner, Benjamin Foerg, Kathleen Mackie-Haas, Jürgen Junk

“…This investigation aimed (i) to obtain phenological observation datasets of PIWI cultivars across a broad set of European locations, (ii) to apply the temperature sum based “UniPhen” model allowing for a precise simulation of the phenological development at all BCCH stages between bud swelling and berries ripe for harvest and (iii) to discuss the potential implementations in applied viticulture as well as in viticultural climate change impact research. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…We sought to evaluate the feasibility of implementing a multidisciplinary mobile outreach clinic for unhoused individuals with a focus on diabetic foot care and screening to overcome the SDoH-associated barriers to care. …”
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Towards Personalized Recovery in Handball? The Effects of Playing Positions and Player Role on Internal Match Load and Well-Being Responses in Female Players by Carlos García-Sánchez, Raúl Nieto-Acevedo, Jorge Lorenzo-Calvo, Moisés Marquina Nieto, Rafael Manuel Navarro, Alfonso de la Rubia

“…Therefore, coaches and practitioners should consider the internal match load and well-being status of players to implement different training stimuli (e.g., recovery or compensatory strategies) in MD+1 according to playing positions and player roles.…”
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Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis by Zhenhu Chen, Pingping Jia, Di Xie, Jingyu Xie, Juan Liu, Wangnan Cao, Lefei Han, Jinjun Ran, Shengzhi Sun, Shi Zhao, Yang Ge, Leonardo Martinez, Xin Chen, Peihua Cao

“…This highlights the effectiveness of current policies and prevention measures implemented to mitigate the impact of the pandemic.…”
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Patient and public involvement in international research: Perspectives of a team of researchers from six countries on collaborating with people with lived experiences of dementia a... by Shirin Vellani, Marie‐Lee Yous, Vanessa Maradiaga Rivas, Stephanie Lucchese, Julia Kruizinga, Tamara Sussman, Julia Abelson, Noori Akhtar‐Danesh, Gina Bravo, Kevin Brazil, Rebecca Ganann, Sharon Kaasalainen

“…The mySupport study involved implementing the Family Carer Decision Support (FCDS) intervention for care partners of those living with advanced dementia in LTC in six countries. …”
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Directional hand movement can be classified from insular cortex SEEG signals using recurrent neural networks and high-gamma band features by Xiecheng Shao, Ryan S. Chung, Jonathon M. Cavaleri, Roberto Martin Del Campo-Vera, Miguel Parra, Shivani Sundaram, Selena Zhang, Ashwitha Surabhi, Ryan J. McGinn, Charles Y. Liu, Spencer S. Kellis, Brian Lee

“…Structures beyond motor cortex have provided additional sources for movement signals. New evidence points to the role of the insula in motor control, specifically directional hand-movements. …”
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Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus by А. N. Kazantsev, R. A. Vinogradov, M. A. Chernyavsky, V. N. Kravchuk, D. V. Shmatov, A. A. Sorokin, A. A. Erofeev, V. A. Lutsenko, R. V. Sultanov, A. R. Shabaev, I. M. Radjabov, G. Sh. Bagdavadze, N. E. Zarkua, V. V. Matusevich, E. F. Vaiman, A. I. Solobuev, S. V. Artyukhov, R. Yu. Lider, V. A. Porkhanov, G. G. Khubulava

“…Depending on the presence / absence of type 2 diabetes and the type of implemented CEE, 4 groups were formed: group 1 — 12.2% (n = 702) — patients with type 2 diabetes and eversion CEE; Group 2 — 55.0% (n = 3153) patients without type 2 diabetes and eversion CEE; Group 3 — 8.5% (n = 484) patients with type 2 diabetes and classical CEE; Group 4 — 24.3% (n = 1392) patients without type 2 diabetes and classical CEE. …”
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Comprehensive Survey of PCV2 and PCV3 in Domestic Pigs and Wild Boars Across Portugal: Prevalence, Geographical Distribution and Genetic Diversity by Bernardo Almeida, Margarida D. Duarte, Ana Duarte, Teresa Fagulha, Fernanda Ramos, Tiago Luís, Inês Caetano, Sílvia C. Barros, Fábio Abade dos Santos, Ana Margarida Henriques

“…The lower PCV2 prevalence in pigs can be attributed to the PCV2 vaccination program implemented. Additionally, these viruses were significantly more prevalent in wild boars (90.8% were infected with at least one of the viruses) than in domestic pigs (only 12.5%). …”
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Rationale and design of the HERZCHECK trial: Detection of early heart failure using telemedicine and cardiovascular magnetic resonance in structurally weak regions (NCT05122793) by Sebastian Kelle, Anna Clara Nolden, Maximilian Leo Müller, Rebecca Elisabeth Beyer, Henning Steen, Bjoern Andrew Remppis, Johannes Wieditz, Hannah Kentenich, Alex Tuit, Mina Cvetkovic, Undine Ella Witt, Florian André, Sein Schmidt, Alexander Huppertz, Dusan Simic, Dirk Müller, Arim Shukri, Matthias Issing, Andre Glardon, Katrin Christiane Reber, Ulf Landmesser, Norbert Frey, Burkert Pieske, Stephanie Stock, Volkmar Falk, Tim Friede, Gisela Thiede

“…Ten percent of participants in stratum A and all of stratum B and C are subsequently randomized into two groups, receiving either conventional or innovative medical reports, the latter including information on GLS, guideline-based recommendations, and access to a lifestyle intervention app for cardiovascular prevention. Additionally, treating physicians of participants in the innovative group are granted access to an expert center for telemedical inquiries. …”
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Analysis of the Contextual Factors Influencing the Expansion of Construction Violations with an Emphasis on the Role and Position of Key Urban Stakeholders (Case Study: Isfahan Met... by Ahmad Shahivandi, Afsaneh Talebi Varnosfaderani

“…Among these, the poor performance in public housing provision with a factor loading of 0.95 stood out as a critical issue. Additionally, the failure to implement systems to mitigate the impact of inflation on housing costs with a factor loading of 0.821 and the restrictions on bank credits for loans related to purchasing and building housing with a factor loading of 0.812 were identified as key factors contributing to the weaknesses in the government's public and civil construction initiatives.Social and Cultural Dimensions: In this aspect, social factors accounted for approximately 36% of the model, while cultural factors accounted for about 26%. …”
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The moderating effect of self-efficacy on the relationship between parents and children and academic participation, considering the mediating variable of learning adaptation among... by meysam karamipour, samaneh mataji, rezvaneh kazem nezhad, maryam esfandyari

“…It is also defined as a person's judgment about his abilities to organize and implement specific activities in order to obtain various academic performance plans (Kostagiolas et al, 2019).   …”
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