Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1 by Sha Xiao, Tianjing Wei, Mingyang Xiao, Mingming Shan, Ziqi An, Na Li, Jing Zhou, Shuang Zhao, Xiaobo Lu

“…Furthermore, reactive oxygen species (ROS), endothelin-1 (ET-1), and [Ca²⁺]_i levels were detected in human aortic endothelial cells (HAECs) treated with nicotine, and the relationship between transcription factor activator protein 1 (AP1) and the target genes was further elucidated through ChIP–qPCR. …”
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THE ROLE OF AP-1 TRANSCRIPTION FACTOR ACTIVATION IN THE CHANGES OF PRODUCTION AND UTILIZATION OF NITRIC OXIDE IN THE GASTRIC MUCOSA OF RATS UNDER CONDITIONS OF CHRONIC FLUORIDE INT... by O. Ye. Akimov

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Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1 by Haoan Yi, Yibing Jiang, Wei Li, Ling Shen, Wei Zhang, Shude Li, Yushan Xu, Fei Li

“…RNA-seq data indicated a downregulation of Activator Protein 1 (AP-1), composed of FOS and JUN, at the transcriptional level. …”
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Can activator protein-1 transcription factors be monitored in the maternal circulation to predict set on labor? by Toghrul Yahyayev, Tugce Senturk Kirmizitas, Ali Benian, Tuba Gunel

“…Objective We aimed to compare gene expression levels in myometrial tissues and serum from pregnant women undergoing cesarean section (CS) with and without uterine contractions. The myometrial activator protein-1 (AP-1) transcription factor family (JUN, FOS, and fos-related antigen-2 [FOSL2]) was evaluated as a contraction-related marker in maternal circulation to predict labor timing. …”
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Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance by Xinni Xue, Zhiwei Li, Jiahui Zhao, Ziyi Zhao, Zhihang Li, Yong Li, Yawen Liu, Huan He

“…Abstract Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. …”
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PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy by Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera

Subjects: “…Activator protein-1 (AP-1)…”
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The AP-1 factor JUNB correlates with poor survival of patients with esophageal adenocarcinoma by Nikolai Schleussner, Karl Knipper, Ella Leugner, Christian Goddemeier, Uraz Yasar, Naita M. Wirsik, Jin-On Jung, Hans F. Fuchs, Lars M. Schiffmann, Alexander Quaas, Christiane J. Bruns, Thomas Schmidt

“…Abstract Malignant cells have in contrast to non-transformed cells de-regulated transcriptional networks. The activator protein-1 (AP-1) transcription factor complex is expressed in many cancer entities including adenocarcinomas and has been correlated to de-regulated transcription and tumor-promoting mechanisms. …”
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NFκB and AP-1 Drive Human Myometrial IL8 Expression by Shirin Khanjani, Vasso Terzidou, Mark R. Johnson, Phillip R. Bennett

“…The IL8 promoter contains binding sites for the transcription factors nuclear factor-kappa B (NFκB), activator protein-1 (AP-1), and CCAAT/enhancer-binding protein (CEBP). …”
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TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei by Nadine Weisert, Verena Majewski, Laura Hartleb, Katarina Luko, Liudmyla Lototska, Nils Christian Krapoth, Helle D. Ulrich, Christian J. Janzen, Falk Butter

“…Three functional homologs of mammalian telomere complex proteins have been characterized thus far, and novel telomere-interacting proteins, such as telomere-associated protein 1 (TelAP1), have recently been identified. …”
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Endoplasmic reticulum stress activates the hepatic activator protein 1 complex via mitogen activated protein kinase-dependent signaling pathways. by Shantel Olivares, Richard M Green, Anne S Henkel

“…<h4>Background and aims</h4>Endoplasmic reticulum (ER) stress is induced in many forms of chronic liver disease and may promote the development of hepatocellular carcinoma. The activator protein 1 (AP-1) complex is a transcription factor that promotes hepatic carcinogenesis in response to cellular stress. …”
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Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1. by Tara Rao, Gloria Ruiz-Gómez, Timothy A Hill, Huy N Hoang, David P Fairlie, Jody M Mason

“…These short structured peptides are entropically pre-organized for binding with high affinity and specificity to cFos, a key component of the oncogenic transcriptional regulator Activator Protein-1 (AP-1). They competitively antagonized the cJun-cFos coiled-coil interaction. …”
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Recombinant Type XVII Collagen Inhibits EGFR/MAPK/AP-1 and Activates TGF-β/Smad Signaling to Enhance Collagen Secretion and Reduce Photoaging by Ying He, Shiyu Yin, Ru Xu, Yan Zhao, Yuhang Du, Zhiguang Duan, Daidi Fan

“…Modulating the transforming growth factor (TGF)-β/Smad and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) pathways suppressed photoaging. …”
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Topical TYK2 inhibitor ameliorates psoriasis‐like dermatitis via the AKT‐SP1‐NGFR‐AP1 pathway in keratinocytes by Zhiqin Fang, Rundong Jiang, Yutong Wang, Wangqing Chen, Xiang Chen, Mingzhu Yin

“…This impairment hindered the activation of activator protein 1 (AP1), thereby weakening the proinflammatory potential of KCs. …”
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microRNA-21对膀胱癌T24细胞增殖的影响 及对VEGF和AP1蛋白的调节

“…【目的】 研究microRNA-21(miR-21)对膀胱癌T24细胞系中血管内皮生长因子(vascular endothelial growth factor, VEGF)和活化因子蛋白-1(activator protein-1, AP1)及mRNA表达的调节作用,探讨miR-21对膀胱癌T24细胞增殖的影响65377; 【方法】 用人工合成的miR-21相应的双链互补DNA片段,插入pSilencerTM 3.1-H1 neo载体表达载体,经测序鉴定后作为microRNA的表达质粒;用脂质体将miR-21高表达质粒转染进T24膀胱癌细胞,经G418筛选获得阳性克隆65377;用RT-PCR技术和Western blot方法分别检测该细胞系中VEGF和AP1的mRNA和蛋白表达情况65377;四甲基偶氮唑蓝(MTT)法检测膀胱癌T24细胞增殖的变化情况65377;【结果】 Western blot结果显示miR-21能够增加VEGF和AP1蛋白的表达,RT-PCR方法分析显示VEGF和AP1 mRNA水平升高65377;MTT显示转染后细胞的生长速率比未转染的细胞明显加快65377;【结论】 miR-21促进T24膀胱癌细胞增殖, 提示可能与VEGF和AP1 的低表达有关65377;…”
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Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis by Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo

“…Specific ablation of Slc25a49 in cardiomyocytes leads to exacerbated Dox‐induced cardiomyopathy, characterized by compromised mitochondrial respiration enhanced glycolysis and increased glycolytic metabolite glucose‐6‐phosphate (G6P) levels, subsequently activating the activator protein‐1 (AP‐1) complex. The stimulation of the G6P–AP‐1 axis intensifies myocardial damage via transcriptionally regulating Sarcolipin (Sln) expression. …”
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Inhibited Production of iNOS by Murine J774 Macrophages Occurs via a phoP-Regulated Differential Expression of NFκB and AP-1 by Scott D. Hulme, Paul A. Barrow, Neil Foster

“…We compared expression of inducible nitric oxide synthase (iNOS) mRNA and protein, and nitrite ion production and also examined binding of nuclear factor 𝜅B (NF𝜅B) and activator protein 1 (AP-1) to macrophage DNA. Results. …”
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Prmt1-mediated methylation regulates Ncoa4 stability to transactivate Adamts genes and promote bone extracellular matrix degradation in chronic hematogenous osteomyelitis by Xun Chen, Ning Duan, Wentao Zhang, Tao Song, Fei Cong

“…Methylated Ncoa4 formed a transcriptional complex with the histone acetyltransferase Cbp (CREB-binding protein) and transcription factor Ap1 (Activator protein 1), driving the expression of four Adamts genes (Adamts3/8/12/14) that promoted extracellular matrix (ECM) degradation in osteoblasts and osteocytes. …”
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Drug repurposing in the treatment of chronic inflammatory diseases by Shivmuni Sarup, Alexander G. Obukhov, Shubhi Raizada, Rajat Atre, Mirza S. Baig

“…Main body Here, we discuss the importance of two key transcription factors: nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1), in orchestrating complex pathophysiological signaling networks involved in chronic inflammatory diseases. …”
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Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis by Han Yan, Wenjun Liu, Rui Xiang, Xin Li, Song Hou, Luzheng Xu, Lin Wang, Dong Zhao, Xingkai Liu, Guoqing Wang, Yujing Chi, Jichun Yang

“…Upon phosphorylation at Thr45 and activation, BHMT1 eliminated homocysteine (Hcy) to inhibit the activity of transcription factor activator protein 1 (AP1) and its induction on fatty acid synthase (FASn) and cluster of differentiation 36 (CD36) gene transcriptions, concurrently repressing lipid synthesis and uptake in hepatocytes. …”
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Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma by David Vallois, Mélanie Juilland, Kalliopi Ioannidou, François Lemonnier, Edoardo Missiaglia, Bettina Bisig, Margot Thome, Laurence de Leval

“…Concomitant expression of RHOA G17V and CD28 T195P induced significantly higher levels of interleukin-2 (IL-2) production and NFAT nuclear factor of activated T cells (NFAT) and activator protein 1 (AP1) transcriptional activities than either variant alone upon T-cell activation with agonistic anti-CD3 and anti-CD28 antibodies. …”
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