Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis by Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti

“…Clinical implications of E-cadherin perturbations in host pathophysiology are emphasized; downregulation, proteolytic phenomena, abnormal localization/signaling and aberrant immune reactions are linked with a broad spectrum of pathology beyond infectious diseases. …”
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

“…Dietary fat supplementation further boosts sebum production and partially rescues both the lipoatrophy and the aberrant skin phenotypes. The data establish a critical role for cytosolic acetyl-CoA synthesis in maintaining skin barrier integrity and highlight the skin as a key organ in systemic lipid regulation.…”
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Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage by Weibin Du, Wenxiang Zeng, Zhenwei Wang, Huahui Hu, Hongfeng Ruan, Gang Qu

“…In conclusion, our study suggests that CPF exposure primarily induces skin damage by disrupting tissue structure and function, mediated through apoptosis and proliferation processes in skin cells, alongside aberrant angiogenesis and heightened inflammatory response. …”
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Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis by Christopher Robinson, Cynthia Pham, Alec M. Zamarripa, Chase S. Dugay, Christopher A. Lee, Amnon A. Berger, Avi Landman, Elyse M. Cornett, Hisham Kassem, Alan D. Kaye, Ivan Urits, Omar Viswanath, Latha Ganti

“…# Background Amyloidosis is a group of diseases with the common pathophysiology of protein misfolding and aberrant deposition in tissue. There are both acquired and hereditary forms of this disease, and this review focuses on the latter hereditary transthyretin-mediated (hATTR). hATTR affects about 50,000 individuals globally and mostly appears as one of three syndromes - cardiac, polyneuropathy, and oculoleptomeningeal. …”
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Higgs decay into massive b-quarks at NNLO QCD in the nested soft-collinear subtraction scheme by Arnd Behring, Wojciech Bizoń

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Discriminatory Practices against Women in Labour Relations in Nigeria: Interrogating the Position of International Law by Atah Pine, Ochoga Edwin Ochoga

“…Therefore, any contractual agreement aims at discriminating workers on the basis of their sex amount to an aberrational act. The paper has equally discovered that the fear of losing one’s job often makes women to work under any condition whatsoever which is different from the position of international law. …”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…Our methodology brings critical insights into chromosomal aberrations and highlights the ubiquitous aneuploidy process during tumorigenesis. …”
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Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers by Hua Huang, Huibo Lian, Wang Liu, Benyi Li, Runzhi Zhu, Haiyan Shao

“…Recent studies showed that they were aberrantly expressed in certain human cancers. However, there is a paucity of information about their expression in prostate cancer. …”
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Real-time adaptive optics for high-power laser beam correction in the strong turbulence by A.L. Rukosuev, A.N. Nikitin, I.V. Galaktionov, Y.V. Sheldakova, A.V. Kudryashov

“…Using information received from Shack-Hartmann wavefront sensor, a bimorph-based adaptive mirror, controlled by another FPGA, is able to compensate for wavefront aberrations for up to 23-th Zernike polynomial in real time. …”
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Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer by Xiao Lin, Sijia Sun, JiWen Zhang, Yan Cai, Quan Cheng

“…In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in esophageal cancer. …”
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JEAN BODIN'S NOTION OFSOVEREIGNTY, GOOD GOVERNANCE AND NTHE QUEST FOR SOCIOPOLITICALADVANCEMENT IN NIGER by EKUASE INNOCENT O., COLLINS OKONKWO, EDOGIAWERIE MORRIS K.O.

“…For Bodin, it is an aberration for church fathers to delve into and perpetrate themselves in matters that don't concern the church and its administration.He concurs with Platothat the business of state (Administration) is not a child's play but a very serious business that requires absolute focus and expertise otherwise the essence of the tacit consent would be highly compromised. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

“…GSK-3β modulates diverse protein targets through phosphorylation, and its aberrant activity leads to neurological complications as well as tumour onset. …”
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Comprehensive epidemiological evaluation of ruminant brucellosis and associated risk factors in some Egyptian Governorates by Nesreen Allam Tantawy Allam, Mahinour Ezzeldin Abdelsalam, Hend I. Elsharkawy, Mai Mohamed Kandil, Amany Mohamed Mohamed Mohamed, Fatma Ali, Mohamed A. Gebely, Safaa Y. Nour, Doaa Sedky, Mona Ebrahim Hussien Abd El-Gawad, Hoda M. Zaki, Nazek Al-Gallas, Amal M. Aboelmaaty, Mona Mohamed Sobhy, Nagwa Sayed Ata, Marwa Salah Abdel-Hamid, Ghada A. Badawy

“…There were 8 types of chromosomal aberrations detected in peripheral white blood cells. …”
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Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells by Xuanhe Fu, Zhixiong Yu, Fang Fang, Weiping Zhou, Yuxin Bai, Zhongjia Jiang, Biao Yang, Ye Sun, Xing Tian, Guangyan Liu

“…OC cells utilize cellular metabolic reprogramming to gain a survival advantage, particularly through aberrant lipid metabolic process. As the primary ingredient in exogenous cannabinoids, cannabidiol (CBD) has been confirmed to exhibit antitumor activity in preclinical studies. …”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

“…However, the addition of the mitochondrion-targeted antioxidant SS-31 and the ferroptosis inhibitor Fer-1 reversed the harm to the ovaries from co-exposure to PS-NPs and Cd, the aberrant expression of genes related to the SIRT3-SOD2/Gpx4 pathway was also improved. …”
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Identification of Houge type of X-linked syndromic mental retardation caused by CNKSR2 truncated variants by Si-Hua Chang, Jie-Yuan Jin, Yi-Qiao Hu, Run-Yan Wang, Rong Xiang, Xia Wang

“…Minigenes results revealed that variant c.1658-3_1676del produced an aberrant spliceosome assembly. Conclusions We identified two novel CNKSR2 variants in MRXSHG families, expanding the variant spectrum of CNKSR2, enriching MRXSHG-related phenotypes, and contributing to genetic counseling for MRXSHG patients.…”
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Comparative gametogenesis and genomic signatures associated with pollen sterility in the seedless mutant of grapevine by Siddhi Chavan, Satish Phalake, Sujata Tetali, Vitthal T. Barvkar, Ravindra Patil

“…RNAseq and genome sequencing data collectively indicate parthenocarpic seedless phenotype due to aberrant developmental and physiological processes involved in pollen formation, maturation and germination in the seedless mutant of ARI 516. …”
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Developing a new clinical governance framework for chronic diseases in primary care: an umbrella review by Walter Ricciardi, Gianfranco Damiani, Alessandra Buja, Vincenzo Baldo, Mark H Ebell, Roberto Toffanin, Mirko Claus

“…Objectives Our goal is to conceptualise a clinical governance framework for the effective management of chronic diseases in the primary care setting, which will facilitate a reorganisation of healthcare services that systematically improves their performance.Setting Primary care.Participants Chronic Care Model by Wagner et aland Clinical Governance statement by Scally et alwere taken for reference. Each was reviewed, including their various components. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Notably, silencing FhCTNNB1, the key effector of the Wnt/β-catenin signal cascade led to aberrant development of the neuromuscular system which ultimately proved lethal - the first report of a lethal RNAi-induced phenotype in F. hepatica. …”
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Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population by Nuwayyir Abdullah Alqasimi, Lujain Hatim Aljohani, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Bader Saad AlQahtani, Bader Saad AlQahtani, Nasser Saleh Al Haydar, Bdour Raja Alanazi, Danah Tariq Alfurayhan, Lina Sami Hussain Saber, Fatemah Saleh Alsalem, Nawaf Abdullah Alqahtani, Jose Manuel Vargas

“…BackgroundKeratoconus (KC) is a bilateral, asymmetric, progressive thinning of the cornea that causes a decrease in optical quality due to induced myopia, irregular astigmatism, and higher order aberrations. KC affects 1.38 per 1,000 individuals globally, with a higher prevalence in Asian and Middle Eastern populations. …”
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