Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment by Jianwei Qiu, Grigorios M. Karageorgos, Xiaorui Peng, Soumya Ghose, Zhaoyuan Yang, Aaron Dentinger, Zhanpeng Xu, Janggun Jo, Siddarth Ragupathi, Guan Xu, Nada Abdulaziz, Girish Gandikota, Xueding Wang, David Mills

“…However, automatic segmentation of the synovium in 3D ultrasound is challenging due to ambiguous boundaries, variability in synovium shape, and inhomogeneous intensity distribution. …”
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Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks by Ahmed Mateen Buttar, Zubair Shaheen, Abdu H. Gumaei, Mogeeb A. A. Mosleh, Mogeeb A. A. Mosleh, Indrajeet Gupta, Samah M. Alzanin, Muhammad Azeem Akbar

“…Moreover, performance metrics such as precision, recall, and F1-score were calculated separately, confirming the robustness and efficiency of our model across various evaluation criteria. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…While habitat composition and planting strategies offer substantial localized benefits, their variability necessitates tailored interventions informed by specific ecological and social contexts. …”
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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…These mAbs recognized the hyper-variable-region (HVR) 1, 2, or 7 of viral hexon protein, or the fibre knob. …”
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Sensitivity Analysis of Soil Hydraulic Parameters for Improved Flow Predictions in an Atlantic Forest Watershed Using the MOHID-Land Platform by Dhiego da Silva Sales, Jader Lugon Junior, David de Andrade Costa, Renata Silva Barreto Sales, Ramiro Joaquim Neves, Antonio José da Silva Neto

“…The hydraulic soil parameters of VGM are dependent on soil type and are typically estimated from experimental data; however, they are often obtained using pedotransfer functions, which carry significant uncertainty. As a result, calibration is frequently required to account for both the natural spatial variability of soil and uncertainties estimation. …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…Abstract The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xv] The center they present to and the variable evaluative criteria the center uses may discount an individual’s claim to a fair opportunity to access a scarce resource. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…The outcomes of local-level forest governance depend on the quality, efficiency, and effectiveness of local policymaking and decision-making processes, as well as how power and authority are exercised locally. …”
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Learning compositional sequences with multiple time scales through a hierarchical network of spiking neurons. by Amadeus Maes, Mauricio Barahona, Claudia Clopath

“…The hierarchical model redistributes the variability: it achieves high motif fidelity at the cost of higher variability in the between-motif timings.…”
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Optimal Design of Interior Permanent Magnet Synchronous Motor Considering Various Sources of Uncertainty by Giacomo Guidotti, Dario Barri, Federico Soresini, Massimiliano Gobbi

“…The method incorporates an innovative use of the neural network-based variance estimation (NNVE) technique to efficiently calculate the standard deviation of the objective functions. …”
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La biodiversidad y los servicios ecosistémicos en sistemas agroecológicos. Una revisión by Wendy Mercedes Ramírez-Suárez, Jorge Carlos López-Chouza, María de los Ángeles Flores-Acosta, Saray Sánchez-Cárdenas, Pedro Lázaro Rodríguez-Morejón

“…There is a strong interrelationship between the functioning of biodiversity and the development of ecosystem processes that will subsequently form the basis of production, based on the richness and spatial and temporal variability of species, their performance in the complexity of ecosystems and the maintenance of ecosystem services at different scales.…”
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A Robust Multi-Objective Evolutionary Framework for Artificial Island Construction Scheduling Under Dynamic Constraints by Tianju Zheng, Liping Sun, Mingwei Li, Guangyao Yuan, Shuqi Li

“…MACEMGA combines cooperative coevolution, adaptive dynamic weighting, dynamic penalty functions, and advanced genetic operators to navigate the solution space efficiently and identify Pareto optimal schedules. …”
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Nitrogen deposition favors later leaf senescence in woody species by Jian Wang, Xiaoyue Wang, Josep Peñuelas, Hao Hua, Chaoyang Wu

“…Changes in climate conditions and nitrogen deposition levels jointly controlled the direction of date of foliar senescence trends (advance or delay). The spatial variability of nitrogen deposition effects can be related to plant traits (e.g., nitrogen resorption and use efficiencies), climatic conditions, and soil properties. …”
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Ectopic expression of vaccinia virus E3 and K3 cannot rescue ectromelia virus replication in rabbit RK13 cells. by Erin S Hand, Sherry L Haller, Chen Peng, Stefan Rothenburg, Adam R Hersperger

“…However, there is individual variability in the range of species able to be productively infected. …”
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ClimKern v1.2: a new Python package and kernel repository for calculating radiative feedbacks by T. P. Janoski, T. P. Janoski, T. P. Janoski, T. P. Janoski, T. P. Janoski, I. Mitevski, R. J. Kramer, M. Previdi, L. M. Polvani, L. M. Polvani, L. M. Polvani

“…The radiative kernel method is commonly used to efficiently compute individual climate feedbacks from climate model or reanalysis output. …”
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Spatial Differentiation and Correlation of Ecological Stoichiometric Characteristics of Cynodon dactylon and Soil in the Water-level Fluctuation Zone of the Three Gorges Reservoir... by XU Liwen, ZHANG Yuewei, JIAN Chen, ZHANG Yuanyuan, WANG Xiaofeng

“…However, the variability in C/N and C/P ratios in roots and stems were slightly stronger than that in leaves, suggesting that C. dactylon has evolved a strategy for maintaining stable physiological functions in leaves. 4) There were significant correlations of the nutrient contents between C. dactylon and soil, with the nitrogen supply of soil being the key factor influencing the variation of nutrient contents in C. dactylon. …”
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