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Binding patterns of glycine receptor autoantibodies are related to clinical syndromes
Published 2025-07-01“…How the underlying autoantibody associated pathomechanisms contribute to the variability of clinical presentations, is so far not understood. …”
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.
Published 2007-07-01“…In a bladder cell culture system, beta1 and alpha3 integrin receptors co-localize with invading type 1-piliated bacteria and F-actin. …”
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Body Temperature Differences Between Green And Brown Grasshoppers Do Not Result From Thermal Physiology or Thermal Preferences
Published 2025-03-01“…ABSTRACT Colour polymorphisms correspond to the co‐occurrence of several distinct colour morphs that vary in hue and/or brightness, independently of sex, age or any other state‐dependent modifiers. …”
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Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy
Published 2025-01-01“…Abstract α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of unassociated KLA is shed as soluble KLA (sKLA) to exert FGFR/FGF23-independent pleiotropic functions. …”
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Characterization and clustering of intra-day physical activity patterns using accelerometry among sexual and gender minority adults
Published 2025-07-01“…., clusters) of daily PA trajectories among sexual and gender minority (SGM; lesbian, gay, bisexual, transgender, queer) adults using functional latent block models (FLBMs), a co-clustering technique that simultaneously accounts for variation at the individual- and day-level. …”
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Protein epigenetic scores and overall mortality in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
Published 2025-03-01“…Abstract Introduction DNA methylation (DNAm) has a functional role in gene regulation, and it has been used to estimate various human characteristics. …”
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Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?
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The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake
Published 2025-05-01“…Within these venom systems, the molecular, cellular, and morphological components interact and co-evolve to generate distinct, venom phenotypes that are increasingly recognized as models for studying adaptive evolution. …”
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Marine environmental monitoring programmes in South Africa: a review
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A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].
Published 2014-05-01“…We show that the null phenotype is rescued more effectively by an Lmx1b transgene than is Icst. Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes. …”
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High performance of a low input, mixed western Australian farming system: public policy implications from the case of Tolga farm
Published 2023-11-01“…Estimated profitability is around the median of a leading consultant’s cohort of farmers for that rainfall zone; however, the low variability in its profit is reflective of the top 25% of the cohort, ranked on profit (gross margin) per hectare. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials
Published 2023-03-01“…A requirement for simultaneous allograft co-listing can safeguard the interests of vulnerable potential subjects. …”
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FAT1-weighted MRI-guided focused ultrasound thalamotomy for essential tremor
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Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data
Published 2025-05-01“…Enterotype classification was performed using principal component analysis, with advanced bioinformatics tools, including Linear Discriminant Analysis Effect Size (LEfSe), eXtreme Gradient Boosting (XGBoost), and Deep Cross-Fusion Networks for Genome-Scale Identification of Pathogens (DCiPatho), to identify differentially abundant microbes and potential pathogens. Microbial co-occurrence networks and functional predictions via PICRUSt2 revealed distinct patterns across enterotypes.Results and discussionThe Prevotella-dominated(ET-P) group exhibited a 33% higher cirrhosis rate than the Bacteroides-dominated(ET-B) group. …”
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