Altered lower leg muscle activation patterns in patients with cerebral palsy during cycling on an ergometer by Alves-Pinto A, Blumenstein T, Turova V, Lampe R

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Group participation and the risk of functional decline in later life: A Prospective Cohort Study by Makoto Kaneko PhD, Fumihiro Saitoh PhD, Hotaka Hara MD, Takako Motomura, Kumiko Maruyama, Yumiko Okamoto BA, Hisako Kuribayashi, Kouichi Imai LLB, Katsunori Kondo PhD

“…The Japanese Health and Welfare Co-operative (Hew Co-op) organises peer-led group participation called ‘Han Kai’ meetings to promote health literacy, but the impact of Han Kai participation on health indicators remains unexplored. …”
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ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease by Rui Shen, Xin Yu, Caifeng Shi, Yi Fang, Chunsun Dai, Yang Zhou

“…The top tertile of baseline ACSL4 was found to identify the subjects with DKD who were at high risk for rapid kidney function decline and a similar significant relationship was found using ACSL4 levels as a continuous variable.ConclusionsACSL4 was associated with a rapid progression of DKD and may serve as a novel pathological biomarker.…”
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Analysis of Electric Vehicle Charging Behavior Patterns with Function Principal Component Analysis Approach by Chenxi Chen, Yang Song, Xianbiao Hu, Ivan G. Guardiola

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A Fluid Flow‐Based Deep Learning (FFDL) Architecture for Subsurface Flow Systems With Application to Geologic CO2 Storage by Zhen Qin, Yingxiang Liu, Fangning Zheng, Behnam Jafarpour

“…We develop a Fluid Flow‐based Deep Learning (FFDL) architecture for spatial‐temporal prediction of important state variables in subsurface flow systems. The new architecture consists of a physics‐based encoder to construct physically meaningful latent variables, and a residual‐based processor to predict the evolution of the state variables. …”
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Ecosystem services and multifunctionality are co-regulated by biotic and abiotic factors along with forest types in a temperate forest of South Korea by Min-Ki Lee, Yong-Ju Lee, Jung-Hwa Chun, A-Reum Kim, Chang-Bae Lee

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Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening by Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji, Achim Doerner

“…Second, a functional screen for internalization was established and comparison of autocrine versus co-encapsulation setups highlighted the advantages of an autocrine one cell approach. …”
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The Co-Piloting Model for Using Artificial Intelligence Systems in Medicine: Implementing the Constrained-Disorder-Principle-Based Second-Generation System by Yaron Ilan

“…The constrained disorder principle (CDP) defines complex biological systems by their degree of regulated variability. This paper describes the CDP-based second-generation AI platform, which is the basis for the Digital Pill that is humanizing AI by moving closer to human biology via using the inherent variability of biological systems for improving outcomes. …”
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The Ocean CO2 Sink in the Canadian Arctic Archipelago: A Present‐Day Budget and Past Trends Due to Climate Change by Mohamed Ahmed, Brent G. T. Else

“…Abstract Arctic shelf seas are highly heterogeneous, making it difficult to accurately account for their role in regional and global air‐sea CO2 exchange budgets. Here we estimate the CO2 sink in the Canadian Arctic Archipelago (CAA) based on empirical relationships that account for spatiotemporal variations in the sea surface partial pressure of CO2 (pCO2sw) as a function of seasonal sea ice cycles. …”
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Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla by Jiao Xu, Wei Zheng, Xiaohong Ou, Hua He, Changgui Yang, Lanping Guo, Chenghong Xiao, Weike Jiang, Guoping Shu, Tao Zhou

“…Results In this study, barcoding PCR combined with high-throughput sequencing was used to efficiently genotype precursor genes encoding CPs in P. heterophylla. …”
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Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells by Aida López Ruiz, Eric Slaughter, Kartik Bomb, Samantha L. Swedzinski, Paige J. LeValley, Zaining Yun, Jacob McCoskey, Kara Levine, Jonathan Steen, Joseph Almasian, Aparajita Chatterjee, Christina Carbrello, Dustin S. Chang, Hubaida Fuseini, Yama A. Abassi, Abraham M. Lenhoff, Catherine A. Fromen, April M. Kloxin, April M. Kloxin

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Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

“…Abstract Background Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothelial function and reduce vascular wall inflammation. …”
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The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control by Zhijing Zhang, Zhijing Zhang, Le Dong, Xin Li, Taibing Deng, Qinglan Wang

“…Clinical progress in PE/PPE-based vaccines, such as M72/AS01E and ID93/GLA-SE, underscores their promise in combating TB, while challenges in epitope variability and functional redundancy demand innovative strategies. …”
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Application of random survival forest for competing risks in prediction of cumulative incidence function for progression to AIDS by Omid Hamid, Mahtab Tapak, Jalal Poorolajal, Payam Amini, Leili Tapak

“…Result: The used model indicated that using antiretroviral therapy tuberculosis co-infection are two top most important variables in predicting cumulative incidence function for AIDS progression in the presence of competing risks, respectively. …”
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INVESTIGATION OF UV/TiO2-ZnO-Co PHOTOCATALITIC DEGRADATION OF AZO DYE (REACTIVE RED 120) BY RESPONSE SURFACE METHODOLOGY by MOHSEN MANSOURI, MARJAN TANZIFI, HOSSEIN LOTFI, MOHSEN NADEMI

“…Results were in agreement with empirical values and the sensitivity analysis showed above parameters as the most efficient variables in decolorization efficiency. Analysis of variance (ANOVA) revealed highly determination coefficient value (R2 = 0.9996 and adjusted-R2 = 0.999) and satisfactory prediction second-order regression model. …”
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Computational modeling of epidemiological count data using Non-Homogeneous Poisson Processes and functional data by Santiago Ortiz, Juan Esteban Chavarría, Henry Velasco

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Near-source wastewater surveillance of SARS-CoV-2, norovirus, influenza virus and RSV across five different sites in the UK. by Jay C Bullen, Mina Mohaghegh, Fatima Tahir, Charlotte Hammer, Jacob Sims, Frederico Myers, Lucas Eisinger, Ali Reza Kasmati, Claire F Trant

“…The key findings are (1) near-source wastewater detections were linked to local events (staff sickness, enhanced cleaning, changing populations); (2) wastewater detections decreased in the order norovirus GII > norovirus GI > SARS-CoV-2 ≈ influenza A ≈ RSV A > influenza B ≈ RSV B; (3) correlation between near-source wastewater data and national surveillance data increases as a function of catchment size and viral prevalence (examples include the SARS-CoV-2 BA.4/BA.5 variant peak at a museum and wastewater tracking the winter norovirus season); (4) strong weekday periodicity in near-source wastewater SARS-CoV-2 detections, with the correlation against COVID-19 case numbers increasing when modelling variable lag times between faecal shedding onset and clinical diagnosis (R2 = 0.45 increases to 0.84-0.86); (5) a log-linear relationship between the frequency of wastewater SARS-CoV-2 detection and log(catchment size⋅viral prevalence) (R2 = 0.6914-0.9066). …”
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Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection. by Ragini Agrawal, Virender Kumar Pal, Suhas K S, Gopika Jayan Menon, Inder Raj Singh, Nitish Malhotra, Naren C S, Kailash Ganesh, Raju S Rajmani, Aswin Sai Narain Seshasayee, Nagasuma Chandra, Manjunath B Joshi, Amit Singh

“…GYY4137 treatment reduced the expression of inflammatory cytokines and re-established the expression of Nrf2-dependent antioxidant genes in the lungs of SARS-CoV-2-infected mice. Notably, non-invasive measurement of respiratory functions using unrestrained whole-body plethysmography (uWBP) of SARS-CoV-2-infected mice showed improved pulmonary function variables, including pulmonary obstruction (Penh), end-expiratory pause (EEP), and relaxation time (RT) upon GYY4137 treatment. …”
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Reinforcement Learning-Based Formulations With Hamiltonian-Inspired Loss Functions for Combinatorial Optimization Over Graphs by Redwan Ahmed Rizvee, Raheeb Hassan, Md. Mosaddek Khan

“…Quadratic Unconstrained Binary Optimization (QUBO) is a versatile approach used to represent a wide range of NP-hard Combinatorial Optimization (CO) problems through binary variables. The transformation of QUBO to an Ising Hamiltonian is recognized as an effective method for solving key optimization problems using quantum algorithms. …”
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Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

“…We used it to assess the effect of long-term consumption of total and non-fermented dairy on cognitive function. Methods We included 43,836 individuals over 55 years old with genotyping, dietary data, and cognitive function measurements from three population-based studies: CoLaus|PsyCoLaus (Switzerland), the Rotterdam Study (the Netherlands) and the Canadian Longitudinal Study on Aging (CLSA - Canada). …”
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